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| Target General Information |
Top |
| Target ID |
T16514 |
Target Info
|
| Target Name |
Fatty acid synthase (FASN) |
| Synonyms |
Yeast fatty acid synthase; Fatty-acyl-CoA synthase; Fatty acyl-CoA synthetase enzyme; FAS |
| Target Type |
Successful Target |
| Gene Name |
FASN |
| Biochemical Class |
Acyltransferase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Peptidases |
[+] 1 Peptidases |
+ |
| Interacting Target Name |
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) |
Preclinical Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
UBP41; Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Biochemical Activity |
[1] |
| References |
Top |
| REF 1 |
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61.
|
| REF 2 |
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle. 2012 Mar 15;11(6):1123-30.
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