Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | E3 ubiquitin-protein ligase HUWE1 (HUWE1) | ||||
| UniProt ID | HUWE1_HUMAN | ||||
| Gene Name | HUWE1 | ||||
| Gene ID | 10075 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Beta-catenin (CTNNB1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | |
| Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Target Info | PPI Info | [3] | ||
| Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [4] | |
| Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [5] | |
| Interacting Literature-reported Target(s) | Multiple tumor suppressor 1 (CDKN2A) | Target Info | PPI Info | [2] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | E3 ubiquitin ligase Mule targets -catenin under conditions of hyperactive Wnt signaling. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1148-E1157. | ||||
| REF 2 | ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell. 2005 Jul 1;121(7):1071-83. | ||||
| REF 3 | Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. Biochem Biophys Res Commun. 2011 Sep 30;413(3):460-4. | ||||
| REF 4 | Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403. | ||||
| REF 5 | Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem. 2007 Aug 10;282(32):23184-93. | ||||
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