Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Notch-1 receptor (NOTCH1) | Clinical trial | Target Info | ||
| UniProt ID | NOTC1_HUMAN | ||||
| Gene Name | NOTCH1 | ||||
| Gene ID | 4851 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [2] | |
| Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | F-box and WD-40 domain protein 7 (Fbxw7) | Target Info | PPI Info | [4] | |
| Recombining binding protein suppressor of hairless (RBPJ) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Down-regulation of Notch-dependent transcription by Akt in vitro. FEBS Lett. 2008 May 28;582(12):1693-9. | ||||
| REF 2 | Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol. 2011 Nov 30;9:83. | ||||
| REF 3 | Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010 Jan 14;29(2):201-13. | ||||
| REF 4 | NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell. 2012 Nov 9;48(3):445-58. | ||||
| REF 5 | RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells. Exp Cell Res. 2010 Jan 15;316(2):149-57. | ||||
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