Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T04827 Target Info
Target Name Recombining binding protein suppressor of hairless (RBPJ)
Synonyms Renal carcinoma antigen NY-REN-30; RBPSUH; RBPJK; RBP-JK; RBP-J kappa; RBP-J; J kappa-recombination signal-binding protein; IGKJRB1; IGKJRB; CBF-1
Target Type Literature-reported Target
Gene Name RBPJ
UniProt ID
SUH_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [9]
10 Affinity Capture-Western [10]
11 Affinity Capture-Western [11]
12 Reconstituted Complex [12]
Interacting Protein Name Msx2-interacting protein (SPEN) Interacting Protein Interacting Protein Info
UniProt ID
MINT_HUMAN 
Synonyms HIAA0929; MINT; RBM15C; SHARP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Reconstituted Complex [13]
Interacting Target Name Methyl cpg binding protein 2 (MECP2) Clinical trial Target Interacting Protein Info
UniProt ID
MECP2_HUMAN 
Synonyms Methyl-CpG-binding protein 2; MethylCpGbinding protein 2; MeCp-2 protein; MeCp2 protein; MeCp2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [14]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Mastermind-like protein 1 (MAML1) Interacting Protein Interacting Protein Info
UniProt ID
MAML1_HUMAN 
Synonyms Mam.1; Mam1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [7]
Interacting Target Name Skeletal muscle LIM-protein 1 (FHL1) Literature-reported Target Interacting Protein Info
UniProt ID
FHL1_HUMAN 
Synonyms SLIM1; SLIM; Skeletal muscle LIMprotein 1; Four and a half LIM domains protein 1; FHL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [15]
Interacting Protein Name SNW domain-containing protein 1 (SNW1) Interacting Protein Interacting Protein Info
UniProt ID
SNW1_HUMAN 
Synonyms Bx42; NCOA.62; PRPF45; Prp45; SKIIP; SKIP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 5 RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells. Exp Cell Res. 2010 Jan 15;316(2):149-57.
REF 6 The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res. 2011 Oct 15;317(17):2438-46.
REF 7 Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol. 2002 Jun;22(11):3927-41.
REF 8 Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol. 2007 Sep;27(18):6506-19.
REF 9 Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7. Neurosci Lett. 2015 Jul 23;600:6-11.
REF 10 The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. J Biol Chem. 2009 May 15;284(20):13384-95.
REF 11 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability. Biochim Biophys Acta. 2013 Jan;1833(1):69-79.
REF 12 Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem. 1997 Apr 25;272(17):11336-43.
REF 13 SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J. 2002 Oct 15;21(20):5417-26.
REF 14 Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ. 2007 Feb;14(2):275-85.
REF 15 FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J. BMC Cancer. 2014 Jun 22;14:463.
REF 16 A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol. 2000 Feb;74(4):1939-47.
REF 17 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol. 2000 Apr;20(7):2400-10.

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