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| Protein General Information (TTD Target) |
Top |
| Full Name |
Homeodomain interacting protein kinase 2 (HIPK2)
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Literature-reported
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Target Info
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| UniProt ID |
HIPK2_HUMAN
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| Gene Name |
HIPK2
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| Gene ID |
28996
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| Interacting TTD Target Information |
Top |
| Interacting Clinical trial Target(s) |
Ubiquitin-protein ligase E3 Mdm2 (MDM2) |
Target Info
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PPI Info
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[1] |
| Cellular tumor antigen p53 (TP53) |
Target Info
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PPI Info
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[2] |
| Interacting Literature-reported Target(s) |
Homeodomain interacting protein kinase 2 (HIPK2) |
Target Info
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PPI Info
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[3] |
| References |
Top |
| REF 1 |
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett. 2005 Oct 24;579(25):5473-80.
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| REF 2 |
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002 Jan;4(1):1-10.
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| REF 3 |
HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. Mol Cell. 2012 Jul 13;47(1):87-98.
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