Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53952 Target Info
Target Name Homeodomain interacting protein kinase 2 (HIPK2)
Synonyms hHIPk2; Homeodomain-interacting protein kinase 2
Target Type Literature-reported Target
Gene Name HIPK2
Biochemical Class Kinase
UniProt ID
HIPK2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase SIAH1 (SIAH1) Interacting Protein Interacting Protein Info
UniProt ID
SIAH1_HUMAN 
Synonyms SIAH1A
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [1]
5 Yeast two hybrid [1]
6 Yeast two hybrid [3]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name DDB1- and CUL4-associated factor 7 (DCAF7) Interacting Protein Interacting Protein Info
UniProt ID
DCAF7_HUMAN 
Synonyms AN11; HAN11; SWAN.1; WDR68
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Co-localization [4]
4 Reconstituted Complex [4]
5 Yeast two hybrid [4]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Biochemical Activity [6]
5 Biochemical Activity [7]
6 Reconstituted Complex [9]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Transcriptional activator Myb (MYB) Interacting Protein Interacting Protein Info
UniProt ID
MYB_HUMAN 
Synonyms Transcriptional activator Myb; Proto-oncogene c-Myb
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [11]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Biochemical Activity [15]
4 Biochemical Activity [14]
5 Co-localization [16]
References  Top
REF 1 An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol. 2009 Jan;11(1):85-91.
REF 2 Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol. 2008 Jul;10(7):812-24.
REF 3 Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1. Cancer Lett. 2009 Jul 8;279(2):177-84.
REF 4 The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010 Nov 17;29(22):3750-61.
REF 5 The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016 Jun 16;6:28241.
REF 6 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002 Jan;4(1):1-10.
REF 7 MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell. 2007 Mar 9;25(5):739-50.
REF 8 XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15532-7.
REF 9 Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation. FEBS Lett. 2005 Jun 6;579(14):3001-8.
REF 10 Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004 Apr 1;18(7):816-29.
REF 11 The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell. 2005 Oct;16(10):4705-13.
REF 12 HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett. 2005 Oct 24;579(25):5473-80.
REF 13 Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta. 2011 Feb;1813(2):283-97.
REF 14 PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. Oncogene. 2009 Feb 5;28(5):698-708.
REF 15 SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell. 2010 Feb 26;37(4):503-15.
REF 16 Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. Exp Cell Res. 2011 Apr 15;317(7):1060-70.

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