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| Protein General Information (TTD Target) |
Top |
| Full Name |
Apoptosis regulator BAK (BAK)
|
Literature-reported
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Target Info
|
| UniProt ID |
BAK_HUMAN
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| Gene Name |
BAK1
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| Gene ID |
578
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| References |
Top |
| REF 1 |
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem. 2001 Dec 6;44(25):4313-24.
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| REF 2 |
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005 Jun 1;19(11):1294-305.
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| REF 3 |
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004 May;6(5):443-50.
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