Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56510 Target Info
Target Name Apoptosis regulator Bcl-xL (BCL-xL)
Synonyms Bcl2like protein 1; Bcl2L1; Bcl2-L-1; Bcl-XL; Bcl-2-like protein 1; BCLX; BCL2L; Apoptosis regulator Bcl-X
Target Type Clinical trial Target
Gene Name BCL2L1
Biochemical Class B-cell lymphoma Bcl-2
UniProt ID
B2CL1_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 2 Alpha-type channels +
Interacting Protein Name Apoptosis regulator BAX (BAX) Interacting Protein Interacting Protein Info
UniProt ID
BAX_HUMAN 
Synonyms BCL2L4
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-localization [3]
4 Fluorescence Resonance Energy Transfer [4]
5 Protein-peptide [5]
6 Reconstituted Complex [6]
Interacting Target Name Apoptosis regulator BAK (BAK) Literature-reported Target Interacting Protein Info
UniProt ID
BAK_HUMAN 
Synonyms CDN1; Bcl-2-like protein 7; Bcl2like protein 7; Bcl2-L-7; Bcl2L7; Bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Fluorescence Resonance Energy Transfer [8]
3 Protein-peptide [5]
Autophagy-related proteins [+] 1 Autophagy-related proteins +
Interacting Target Name Beclin-1 (BECN1) Literature-reported Target Interacting Protein Info
UniProt ID
BECN1_HUMAN 
Synonyms Protein GT197; GT197; Coiled-coil myosin-like BCL2-interacting protein; Coiledcoil myosinlike BCL2interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [10]
Auxiliary transporters [+] 4 Auxiliary transporters +
Interacting Protein Name Bcl2-associated agonist of cell death (BAD) Interacting Protein Interacting Protein Info
UniProt ID
BAD_HUMAN 
Synonyms BBC2; BCL2L8
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
3 Protein-peptide [5]
4 Reconstituted Complex [12]
5 Yeast two hybrid [13]
Interacting Protein Name Bcl-2-like protein 11 (BCL2L11) Interacting Protein Interacting Protein Info
UniProt ID
B2L11_HUMAN 
Synonyms BAM; BIM; BOD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [14]
3 Fluorescence Resonance Energy Transfer [8]
4 Protein-peptide [15]
Interacting Protein Name Bcl-2-modifying factor (BMF) Interacting Protein Interacting Protein Info
UniProt ID
BMF_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Protein-peptide [15]
3 Yeast two hybrid [16]
Interacting Target Name Apoptosis regulator Bcl-2 (BCL-2) Successful Target Interacting Protein Info
UniProt ID
BCL2_HUMAN 
Synonyms Bcl-2; Apoptosis regulator Bcl-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
Beta-barrel porins [+] 1 Beta-barrel porins +
Interacting Target Name Voltage-dependent anion-selective channel 1 (VDAC1) Clinical trial Target Interacting Protein Info
UniProt ID
VDAC1_HUMAN 
Synonyms Porin 31HM; Porin 31HL; Plasmalemmal porin; Outer mitochondrial membrane protein porin 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Cell cycle checkpoint control protein RAD9A (RAD9A) Interacting Protein Interacting Protein Info
UniProt ID
RAD9A_HUMAN 
Synonyms RAD9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Yeast two hybrid [19]
Kinases [+] 1 Kinases +
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [20]
2 Co-localization [3]
Peptidases [+] 1 Peptidases +
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Co-localization [3]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Reconstituted Complex [23]
3 Yeast two hybrid [24]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Apoptosis-stimulating of p53 protein 2 (TP53BP2) Interacting Protein Interacting Protein Info
UniProt ID
ASPP2_HUMAN 
Synonyms 53BP2; ASPP2; BBP; P53BP2; PPP1R13A
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [25]
2 Protein-peptide [25]
3 Yeast two hybrid [24]
Interacting Protein Name Bcl-2-binding component 3 (BBC3) Interacting Protein Interacting Protein Info
UniProt ID
BBC3B_HUMAN 
Synonyms JFY.1; JFY1; PUMA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [27]
3 Protein-peptide [15]
Interacting Protein Name Bcl-2-interacting killer (BIK) Interacting Protein Interacting Protein Info
UniProt ID
BIK_HUMAN 
Synonyms BIP1; BP4; NBK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Protein-peptide [29]
3 Yeast two hybrid [16]
Interacting Protein Name Activator of apoptosis harakiri (HRK) Interacting Protein Interacting Protein Info
UniProt ID
HRK_HUMAN 
Synonyms DP5; HARAKIRI
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Fluorescence Resonance Energy Transfer [8]
3 Protein-peptide [15]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 BAD partly reverses paclitaxel resistance in human ovarian cancer cells. Oncogene. 1998 Nov 12;17(19):2419-27.
REF 3 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 4 BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis. FEBS Lett. 2009 Jun 18;583(12):1873-9.
REF 5 Development of a high-throughput fluorescence polarization assay for Bcl-x(L). Anal Biochem. 2002 Aug 1;307(1):70-5.
REF 6 Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem. 2011 Oct 7;286(40):35308-17.
REF 7 Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005 Jun 1;19(11):1294-305.
REF 8 High-throughput methods to detect dimerization of Bcl-2 family proteins. Anal Biochem. 2003 Nov 15;322(2):170-8.
REF 9 Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem. 2008 Sep 12;283(37):25596-605.
REF 10 Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96.
REF 11 Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. J Biol Chem. 2005 Apr 22;280(16):16045-52.
REF 12 BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem. 1997 Sep 26;272(39):24101-4.
REF 13 Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy. Nature. 1997 Nov 27;390(6658):413-7.
REF 14 Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol Cell Biol. 2005 Nov;25(22):10017-28.
REF 15 BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18;17(4):525-35.
REF 16 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 17 Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22229-32.
REF 18 Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J Biol Chem. 2005 Mar 18;280(11):10491-500.
REF 19 Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis. Nat Cell Biol. 2000 Jan;2(1):1-6.
REF 20 Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint. Cell Cycle. 2012 Jun 1;11(11):2159-69.
REF 21 Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91.
REF 22 Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins. Oncotarget. 2014 Sep 30;5(18):8452-65.
REF 23 Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev. 2010 Oct 1;24(19):2194-204.
REF 24 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 25 Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12277-82.
REF 26 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 27 Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521.
REF 28 Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J. 2003 Jul 15;22(14):3580-90.
REF 29 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005 Feb 4;17(3):393-403.
REF 30 The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. J Biol Chem. 1999 Mar 19;274(12):7975-81.

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