Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Caspase-9 (CASP9) | Clinical trial | Target Info | ||
| UniProt ID | CASP9_HUMAN | ||||
| Gene Name | CASP9 | ||||
| Gene ID | 842 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Apoptosis inhibitor survivin (BIRC5) | Target Info | PPI Info | [1] | |
| Apoptosis regulator Bcl-xL (BCL-xL) | Target Info | PPI Info | [2] | ||
| Caspase-3 (CASP3) | Target Info | PPI Info | [3] | ||
| Cellular inhibitor of apoptosis 1 (BIRC2) | Target Info | PPI Info | [4] | ||
| Cellular inhibitor of apoptosis 2 (BIRC3) | Target Info | PPI Info | [4] | ||
| X-linked inhibitor of apoptosis protein (XIAP) | Target Info | PPI Info | [5] | ||
| Interacting Patented-recorded Target(s) | Melanoma inhibitor of apoptosis protein (ML-IAP) | Target Info | PPI Info | [6] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13103-7. | ||||
| REF 2 | Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91. | ||||
| REF 3 | Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 1;405(1):11-9. | ||||
| REF 4 | IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23. | ||||
| REF 5 | IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81. | ||||
| REF 6 | Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001 Feb 2;276(5):3238-46. | ||||
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