| References |
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| REF 1 |
AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88.
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| REF 2 |
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28.
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| REF 3 |
cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene. 2014 Nov 27;33(48):5534-45.
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| REF 4 |
Ubiquitin-dependent regulation of Cdc42 by XIAP. Cell Death Dis. 2017 Jun 29;8(6):e2900.
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| REF 5 |
OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J. 2013 Apr 17;32(8):1103-14.
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| REF 6 |
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 2002 Mar 21;416(6878):345-7.
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| REF 7 |
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011 Aug;18(8):1376-86.
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| REF 8 |
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem. 2006 Jan 13;281(2):1080-90.
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| REF 9 |
Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem. 2009 Jul 31;284(31):20531-9.
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| REF 10 |
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem. 2011 Jul 29;286(30):26406-17.
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| REF 11 |
The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2. J Biol Chem. 2006 Sep 29;281(39):29022-9.
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| REF 12 |
Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem. 2000 Apr 14;275(15):11114-20.
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| REF 13 |
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16182-7.
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| REF 14 |
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. EMBO J. 2005 May 18;24(10):1886-98.
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| REF 15 |
Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor B (NF-B) signaling. J Biol Chem. 2015 Apr 17;290(16):10395-405.
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| REF 16 |
IB kinase phosphorylates TRAF2 to promote mammary epithelial cell transformation. Mol Cell Biol. 2012 Dec;32(23):4756-68.
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| REF 17 |
TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ. 2015 Nov;22(11):1846-57.
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| REF 18 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 19 |
Asymmetric recruitment of cIAPs by TRAF2. J Mol Biol. 2010 Jul 2;400(1):8-15.
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| REF 20 |
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25.
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| REF 21 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 22 |
IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114.
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| REF 23 |
Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012 Aug 17;287(34):28445-55.
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| REF 24 |
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
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| REF 25 |
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52.
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| REF 26 |
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
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| REF 27 |
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008 May;15(5):859-66.
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| REF 28 |
Parkin regulates NF-B by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 2018 Jun 28;9(7):732.
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| REF 29 |
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
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| REF 30 |
Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-B and Lung Tumorigenesis. Cancer Res. 2016 May 15;76(10):2977-89.
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| REF 31 |
Opposing effect of EGFRWT on EGFRvIII-mediated NF-B activation with RIP1 as a cell death switch. Cell Rep. 2013 Aug 29;4(4):764-75.
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| REF 32 |
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23;36(2):302-14.
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| REF 33 |
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008 Jun 20;30(6):689-700.
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| REF 34 |
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol. 1998 Jul 16;8(15):885-8.
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| REF 35 |
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009 Jun 19;30(6):789-801.
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| REF 36 |
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17). pii: e99372.
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| REF 37 |
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23.
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| REF 38 |
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10;281(6):3254-60.
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| REF 39 |
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000 Nov 2;10(21):1359-66.
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| REF 40 |
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5.
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| REF 41 |
The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66.
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| REF 42 |
Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs. Exp Cell Res. 2006 Jul 15;312(12):2347-57.
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| REF 43 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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| REF 44 |
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005 Jan;7(1):70-7.
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| REF 45 |
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 8;284(19):12772-82.
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| REF 46 |
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. J Biol Chem. 2003 Oct 3;278(40):38699-706.
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| REF 47 |
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001 Sep;8(3):613-21.
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| REF 48 |
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem. 2002 Jan 4;277(1):445-54.
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| REF 49 |
DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017 May 25;8(5):e2816.
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| REF 50 |
Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60.
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| REF 51 |
Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals. Mol Cell Proteomics. 2011 May;10(5):M110.003756.
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| REF 52 |
Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
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| REF 53 |
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. EMBO J. 2015 Feb 3;34(3):307-25.
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| REF 54 |
Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One. 2014 Mar 14;9(3):e92124.
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| REF 55 |
Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81.
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| REF 56 |
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
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| REF 57 |
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73.
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| REF 58 |
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem. 2011 May 13;286(19):17015-28.
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| REF 59 |
The role of ubiquitin-conjugating enzyme Ube2j1 phosphorylation and its degradation by proteasome during endoplasmic stress recovery. J Cell Commun Signal. 2017 Sep;11(3):265-273.
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| REF 60 |
Nuclear factor-B-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem. 2014 Oct 31;289(44):30680-9.
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| REF 61 |
The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36.
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| REF 62 |
Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem. 2004 Apr 23;279(17):16963-70.
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| REF 63 |
Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem. 2015 Apr 17;290(16):9974-85.
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| REF 64 |
An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90.
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| REF 65 |
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 2005 Jan 1;65(1):210-8.
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| REF 66 |
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26;278(39):37297-305.
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| REF 67 |
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation. Mol Cell. 2010 Oct 8;40(1):63-74.
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| REF 68 |
p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun. 2012;3:1061.
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| REF 69 |
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
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| REF 70 |
The seventh zinc finger motif of A20 is required for the suppression of TNF--induced apoptosis. FEBS Lett. 2015 May 22;589(12):1369-75.
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| REF 71 |
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One. 2010 Jun 30;5(6):e11380.
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| REF 72 |
Molecular characterization of CD40 signaling intermediates. J Biol Chem. 2001 Nov 16;276(46):43334-42.
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