Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T84780 Target Info
Target Name Cellular inhibitor of apoptosis 1 (BIRC2)
Synonyms hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
Target Type Clinical trial Target
Gene Name BIRC2
Biochemical Class Acyltransferase
UniProt ID
BIRC2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Ras-related C3 botulinum toxin substrate 1 (RAC1) Literature-reported Target Interacting Protein Info
UniProt ID
RAC1_HUMAN 
Synonyms TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
4 Reconstituted Complex [3]
Interacting Protein Name Cell division control protein 42 homolog (CDC42) Interacting Protein Interacting Protein Info
UniProt ID
CDC42_HUMAN 
Synonyms CDC42Hs; G25K
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [4]
2 Reconstituted Complex [3]
Acyltransferases [+] 3 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [9]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [12]
9 Affinity Capture-Western [13]
10 Affinity Capture-Western [14]
11 Affinity Capture-Western [15]
12 Biochemical Activity [6]
13 Biochemical Activity [16]
14 Biochemical Activity [17]
15 Co-localization [18]
16 Reconstituted Complex [6]
17 Reconstituted Complex [19]
18 Reconstituted Complex [20]
19 Reconstituted Complex [3]
20 Reconstituted Complex [8]
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [22]
Interacting Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target Interacting Protein Info
UniProt ID
BIRC7_HUMAN 
Synonyms UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [23]
3 Yeast two hybrid [24]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [11]
4 Reconstituted Complex [6]
5 Reconstituted Complex [19]
6 Reconstituted Complex [20]
7 Yeast two hybrid [25]
8 Yeast two hybrid [26]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Fluorescence Resonance Energy Transfer [27]
Kinases [+] 2 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [30]
4 Affinity Capture-Western [31]
5 Biochemical Activity [32]
6 Biochemical Activity [24]
7 Biochemical Activity [33]
8 Biochemical Activity [30]
9 Biochemical Activity [29]
10 Reconstituted Complex [29]
Interacting Protein Name Receptor-interacting protein 2 (RIP2) Interacting Protein Interacting Protein Info
UniProt ID
RIPK2_HUMAN 
Synonyms UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [35]
4 Biochemical Activity [29]
5 Reconstituted Complex [35]
6 Reconstituted Complex [29]
7 Reconstituted Complex [36]
Peptidases [+] 4 Peptidases +
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [39]
4 Affinity Capture-Western [40]
5 Affinity Capture-Western [30]
6 Co-crystal Structure [41]
7 Co-localization [18]
8 Protein-peptide [41]
9 Reconstituted Complex [37]
10 Reconstituted Complex [42]
11 Yeast two hybrid [43]
Interacting Target Name Caspase-7 (CASP7) Clinical trial Target Interacting Protein Info
UniProt ID
CASP7_HUMAN 
Synonyms MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [39]
4 Biochemical Activity [45]
5 Reconstituted Complex [45]
6 Reconstituted Complex [20]
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Biochemical Activity [45]
3 Reconstituted Complex [45]
4 Reconstituted Complex [20]
Interacting Protein Name High temperature requirement protein A2 (HTRA2) Interacting Protein Interacting Protein Info
UniProt ID
HTRA2_HUMAN 
Synonyms OMI; PARK13; PRSS25
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-MS [21]
3 Affinity Capture-Western [47]
4 Affinity Capture-Western [48]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Affinity Capture-Western [10]
3 Biochemical Activity [49]
4 Reconstituted Complex [49]
Ubiquitin related proteins [+] 6 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Interacting Protein Interacting Protein Info
UniProt ID
UB2D1_HUMAN 
Synonyms E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [32]
3 Reconstituted Complex [24]
4 Reconstituted Complex [51]
5 Reconstituted Complex [52]
6 Reconstituted Complex [53]
7 Reconstituted Complex [30]
8 Reconstituted Complex [49]
9 Reconstituted Complex [2]
10 Reconstituted Complex [29]
11 Reconstituted Complex [54]
12 Yeast two hybrid [24]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [55]
2 Reconstituted Complex [56]
3 Reconstituted Complex [24]
4 Reconstituted Complex [57]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [58]
2 Reconstituted Complex [6]
3 Reconstituted Complex [45]
4 Yeast two hybrid [24]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Interacting Protein Interacting Protein Info
UniProt ID
UB2D3_HUMAN 
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [50]
3 Yeast two hybrid [24]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Interacting Protein Interacting Protein Info
UniProt ID
UB2J1_HUMAN 
Synonyms HSPC153; HSPC205; HSU93243; NCUBE.1; NCUBE1; UBC6; Ubc6p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Reconstituted Complex [14]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 S (UBE2S) Interacting Protein Interacting Protein Info
UniProt ID
UBE2S_HUMAN 
Synonyms E2.EPF; E2EPF; EPF5
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [51]
2 Yeast two hybrid [24]
Other proteins [+] 5 Other proteins +
Interacting Target Name Direct IAP-binding protein with low pI (DIABLO) Literature-reported Target Interacting Protein Info
UniProt ID
DBLOH_HUMAN 
Synonyms Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [50]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [60]
6 Biochemical Activity [61]
7 Biochemical Activity [50]
8 Co-crystal Structure [41]
9 Protein-peptide [41]
10 Reconstituted Complex [62]
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Reconstituted Complex [64]
3 Reconstituted Complex [63]
4 Reconstituted Complex [65]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [66]
3 Affinity Capture-Western [67]
4 Biochemical Activity [68]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [69]
2 Affinity Capture-Western [70]
Interacting Target Name CD40L receptor (CD40) Clinical trial Target Interacting Protein Info
UniProt ID
TNR5_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 5; TNFRSF5; CDw40; CD40L receptor; Bp50; B-cell surfaceantigen CD40; B-cell surface antigen CD40
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [71]
2 Affinity Capture-Western [72]
References  Top
REF 1 AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88.
REF 2 IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28.
REF 3 cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene. 2014 Nov 27;33(48):5534-45.
REF 4 Ubiquitin-dependent regulation of Cdc42 by XIAP. Cell Death Dis. 2017 Jun 29;8(6):e2900.
REF 5 OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J. 2013 Apr 17;32(8):1103-14.
REF 6 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 2002 Mar 21;416(6878):345-7.
REF 7 Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011 Aug;18(8):1376-86.
REF 8 Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem. 2006 Jan 13;281(2):1080-90.
REF 9 Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem. 2009 Jul 31;284(31):20531-9.
REF 10 Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem. 2011 Jul 29;286(30):26406-17.
REF 11 The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2. J Biol Chem. 2006 Sep 29;281(39):29022-9.
REF 12 Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem. 2000 Apr 14;275(15):11114-20.
REF 13 Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16182-7.
REF 14 TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. EMBO J. 2005 May 18;24(10):1886-98.
REF 15 Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor B (NF-B) signaling. J Biol Chem. 2015 Apr 17;290(16):10395-405.
REF 16 IB kinase phosphorylates TRAF2 to promote mammary epithelial cell transformation. Mol Cell Biol. 2012 Dec;32(23):4756-68.
REF 17 TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ. 2015 Nov;22(11):1846-57.
REF 18 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 19 Asymmetric recruitment of cIAPs by TRAF2. J Mol Biol. 2010 Jul 2;400(1):8-15.
REF 20 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25.
REF 21 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 22 IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114.
REF 23 Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012 Aug 17;287(34):28445-55.
REF 24 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
REF 25 The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52.
REF 26 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 27 Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008 May;15(5):859-66.
REF 28 Parkin regulates NF-B by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 2018 Jun 28;9(7):732.
REF 29 cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
REF 30 Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-B and Lung Tumorigenesis. Cancer Res. 2016 May 15;76(10):2977-89.
REF 31 Opposing effect of EGFRWT on EGFRvIII-mediated NF-B activation with RIP1 as a cell death switch. Cell Rep. 2013 Aug 29;4(4):764-75.
REF 32 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23;36(2):302-14.
REF 33 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008 Jun 20;30(6):689-700.
REF 34 Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol. 1998 Jul 16;8(15):885-8.
REF 35 Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009 Jun 19;30(6):789-801.
REF 36 Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17). pii: e99372.
REF 37 IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23.
REF 38 The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10;281(6):3254-60.
REF 39 ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000 Nov 2;10(21):1359-66.
REF 40 Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5.
REF 41 The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66.
REF 42 Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs. Exp Cell Res. 2006 Jul 15;312(12):2347-57.
REF 43 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 44 IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005 Jan;7(1):70-7.
REF 45 The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 8;284(19):12772-82.
REF 46 The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. J Biol Chem. 2003 Oct 3;278(40):38699-706.
REF 47 A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001 Sep;8(3):613-21.
REF 48 HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem. 2002 Jan 4;277(1):445-54.
REF 49 DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017 May 25;8(5):e2816.
REF 50 Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60.
REF 51 Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals. Mol Cell Proteomics. 2011 May;10(5):M110.003756.
REF 52 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 53 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. EMBO J. 2015 Feb 3;34(3):307-25.
REF 54 Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One. 2014 Mar 14;9(3):e92124.
REF 55 Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81.
REF 56 IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
REF 57 Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73.
REF 58 Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem. 2011 May 13;286(19):17015-28.
REF 59 The role of ubiquitin-conjugating enzyme Ube2j1 phosphorylation and its degradation by proteasome during endoplasmic stress recovery. J Cell Commun Signal. 2017 Sep;11(3):265-273.
REF 60 Nuclear factor-B-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem. 2014 Oct 31;289(44):30680-9.
REF 61 The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36.
REF 62 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem. 2004 Apr 23;279(17):16963-70.
REF 63 Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem. 2015 Apr 17;290(16):9974-85.
REF 64 An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90.
REF 65 cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 2005 Jan 1;65(1):210-8.
REF 66 A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26;278(39):37297-305.
REF 67 A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation. Mol Cell. 2010 Oct 8;40(1):63-74.
REF 68 p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun. 2012;3:1061.
REF 69 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 70 The seventh zinc finger motif of A20 is required for the suppression of TNF--induced apoptosis. FEBS Lett. 2015 May 22;589(12):1369-75.
REF 71 HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One. 2010 Jun 30;5(6):e11380.
REF 72 Molecular characterization of CD40 signaling intermediates. J Biol Chem. 2001 Nov 16;276(46):43334-42.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.