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| Protein General Information |
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| Full Name |
High temperature requirement protein A2 (HTRA2)
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| UniProt ID |
HTRA2_HUMAN
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| Gene Name |
HTRA2
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| Gene ID |
27429
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| Interacting TTD Target Information |
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| Interacting Clinical trial Target(s) |
Cellular inhibitor of apoptosis 1 (BIRC2) |
Target Info
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PPI Info
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[1] |
| X-linked inhibitor of apoptosis protein (XIAP) |
Target Info
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PPI Info
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[2] |
| Interacting Patented-recorded Target(s) |
Melanoma inhibitor of apoptosis protein (ML-IAP) |
Target Info
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PPI Info
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[3] |
| References |
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| REF 1 |
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. J Biol Chem. 2003 Oct 3;278(40):38699-706.
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| REF 2 |
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001 Sep;8(3):613-21.
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| REF 3 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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