Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Receptor-interacting protein 2 (RIP2) | ||||
| UniProt ID | RIPK2_HUMAN | ||||
| Gene Name | RIPK2 | ||||
| Gene ID | 8767 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Cellular inhibitor of apoptosis 1 (BIRC2) | Target Info | PPI Info | [1] | |
| Cellular inhibitor of apoptosis 2 (BIRC3) | Target Info | PPI Info | [1] | ||
| X-linked inhibitor of apoptosis protein (XIAP) | Target Info | PPI Info | [2] | ||
| Pattern recognition receptor NOD2 (NOD2) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Pattern recognition receptor NOD1 (NOD1) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol. 1998 Jul 16;8(15):885-8. | ||||
| REF 2 | Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37(17). pii: e99372. | ||||
| REF 3 | Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 2001 Feb 16;276(7):4812-8. | ||||
| REF 4 | Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7. | ||||
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