Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T31309 Target Info
Target Name Apoptosis regulator Bcl-2 (BCL-2)
Synonyms Bcl-2
Target Type Successful Target
Gene Name BCL2
Biochemical Class B-cell lymphoma Bcl-2
UniProt ID
BCL2_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 5 Alpha-type channels +
Interacting Target Name Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Interacting Protein Info
UniProt ID
B2CL1_HUMAN 
Synonyms Bcl-XL; BCLX; Bcl-2-like protein 1; Bcl2like protein 1; Bcl2-L-1; Bcl2L1; BCL2L; Apoptosis regulator Bcl-X
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Apoptosis regulator BAK (BAK) Literature-reported Target Interacting Protein Info
UniProt ID
BAK_HUMAN 
Synonyms CDN1; Bcl-2-like protein 7; Bcl2like protein 7; Bcl2-L-7; Bcl2L7; Bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-peptide [3]
Interacting Protein Name Apoptosis regulator BAX (BAX) Interacting Protein Interacting Protein Info
UniProt ID
BAX_HUMAN 
Synonyms BCL2L4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [1]
Interacting Protein Name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) Interacting Protein Interacting Protein Info
UniProt ID
BNI3L_HUMAN 
Synonyms BNIP3a; NIX
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Interacting Protein Name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) Interacting Protein Interacting Protein Info
UniProt ID
BNIP3_HUMAN 
Synonyms NIP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [8]
Autophagy-related proteins [+] 1 Autophagy-related proteins +
Interacting Target Name Beclin-1 (BECN1) Literature-reported Target Interacting Protein Info
UniProt ID
BECN1_HUMAN 
Synonyms Protein GT197; GT197; Coiled-coil myosin-like BCL2-interacting protein; Coiledcoil myosinlike BCL2interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Fluorescence Resonance Energy Transfer [10]
3 Yeast two hybrid [10]
Auxiliary transporters [+] 3 Auxiliary transporters +
Interacting Protein Name Bcl2-associated agonist of cell death (BAD) Interacting Protein Interacting Protein Info
UniProt ID
BAD_HUMAN 
Synonyms BBC2; BCL2L8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Far Western [12]
3 Protein-peptide [13]
4 Reconstituted Complex [12]
Interacting Protein Name Bcl-2-like protein 11 (BCL2L11) Interacting Protein Interacting Protein Info
UniProt ID
B2L11_HUMAN 
Synonyms BAM; BIM; BOD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Protein-peptide [13]
3 Reconstituted Complex [14]
Interacting Protein Name Bcl-2-modifying factor (BMF) Interacting Protein Interacting Protein Info
UniProt ID
BMF_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Protein-peptide [13]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine PP2A-alpha (PPP2CA) Clinical trial Target Interacting Protein Info
UniProt ID
PP2AA_HUMAN 
Synonyms Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [16]
Interacting Protein Name Cell cycle checkpoint control protein RAD9A (RAD9A) Interacting Protein Interacting Protein Info
UniProt ID
RAD9A_HUMAN 
Synonyms RAD9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Yeast two hybrid [17]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) Interacting Protein Interacting Protein Info
UniProt ID
FKBP8_HUMAN 
Synonyms FKBP38; FKBPr38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Far Western [19]
3 Reconstituted Complex [20]
Kinases [+] 1 Kinases +
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Yeast two hybrid [21]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Early response protein NAK1 (NR4A1) Literature-reported Target Interacting Protein Info
UniProt ID
NR4A1_HUMAN 
Synonyms Testicular receptor 3; ST-59; Orphan nuclear receptor TR3; Orphan nuclear receptor HMR; Nur77; Nuclear receptor subfamily 4 group A member 1; Nuclear hormone receptor NUR/77; NAK1; HMR; GFRP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Yeast two hybrid [1]
Other proteins [+] 3 Other proteins +
Interacting Protein Name BH3-interacting domain death agonist (BID) Interacting Protein Interacting Protein Info
UniProt ID
BID_HUMAN 
Synonyms FP497
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-fractionation [22]
3 Protein-peptide [23]
Interacting Protein Name Bcl-2-binding component 3 (BBC3) Interacting Protein Interacting Protein Info
UniProt ID
BBC3B_HUMAN 
Synonyms JFY.1; JFY1; PUMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Protein-peptide [13]
Interacting Protein Name Bcl-2-interacting killer (BIK) Interacting Protein Interacting Protein Info
UniProt ID
BIK_HUMAN 
Synonyms BIP1; BP4; NBK
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [23]
2 Yeast two hybrid [25]
References  Top
REF 1 Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004 Feb 20;116(4):527-40.
REF 2 A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008 Oct 7;14(4):285-98.
REF 3 Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem. 2001 Dec 6;44(25):4313-24.
REF 4 Nuclear partners of Bcl-2: Bax and PML. DNA Cell Biol. 2004 Jun;23(6):351-4.
REF 5 Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 1999 Aug 12;18(32):4523-9.
REF 6 BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res. 1999 Feb 1;59(3):533-7.
REF 7 BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem. 2000 Jan 14;275(2):1439-48.
REF 8 Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell. 1994 Oct 21;79(2):341-51.
REF 9 Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J Biol Chem. 2010 Dec 3;285(49):38214-23.
REF 10 Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96.
REF 11 Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. EMBO J. 2005 Jul 20;24(14):2688-99.
REF 12 BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem. 1997 Sep 26;272(39):24101-4.
REF 13 Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006 May;9(5):351-65.
REF 14 Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95.
REF 15 Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 2001 Sep 7;293(5536):1829-32.
REF 16 Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J Biol Chem. 1998 Dec 18;273(51):34157-63.
REF 17 Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis. Nat Cell Biol. 2000 Jan;2(1):1-6.
REF 18 Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol. 2003 Jan;5(1):28-37.
REF 19 A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38. J Biol Chem. 2007 Dec 14;282(50):36496-504.
REF 20 The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90. J Biol Chem. 2007 May 25;282(21):15341-8.
REF 21 Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell. 1996 Nov 15;87(4):629-38.
REF 22 Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20327-32.
REF 23 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005 Feb 4;17(3):393-403.
REF 24 PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001 Mar;7(3):683-94.
REF 25 Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol Cell Biol. 1998 Mar;18(3):1601-10.

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