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| Protein General Information |
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| Full Name |
BH3-interacting domain death agonist (BID)
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| UniProt ID |
BID_HUMAN
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| Gene Name |
BID
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| Gene ID |
637
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Apoptosis regulator Bcl-2 (BCL-2) |
Target Info
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PPI Info
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[1] |
| Interacting Clinical trial Target(s) |
Apoptosis regulator Bcl-W (BCL-W) |
Target Info
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PPI Info
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[2] |
| Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) |
Target Info
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PPI Info
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[3] |
| References |
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| REF 1 |
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20327-32.
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| REF 2 |
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005 Feb 4;17(3):393-403.
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| REF 3 |
Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J Biol Chem. 2005 Mar 18;280(11):10491-500.
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