Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03755 Target Info
Target Name Apoptosis regulator Bcl-W (BCL-W)
Synonyms KIAA0271; Bcl2-L-2; Bcl-2-like protein 2; BCLW
Target Type Clinical trial Target
Gene Name BCL2L2
Biochemical Class B-cell lymphoma Bcl-2
UniProt ID
B2CL2_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Protein Name Apoptosis regulator BAX (BAX) Interacting Protein Interacting Protein Info
UniProt ID
BAX_HUMAN 
Synonyms BCL2L4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Protein Name Bcl2-associated agonist of cell death (BAD) Interacting Protein Interacting Protein Info
UniProt ID
BAD_HUMAN 
Synonyms BBC2; BCL2L8
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Protein-peptide [4]
4 Protein-peptide [5]
5 Yeast two hybrid [6]
Interacting Protein Name Bcl-2-like protein 11 (BCL2L11) Interacting Protein Interacting Protein Info
UniProt ID
B2L11_HUMAN 
Synonyms BAM; BIM; BOD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [5]
3 Yeast two hybrid [7]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Protein-peptide [9]
3 Reconstituted Complex [8]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Bcl-2-interacting killer (BIK) Interacting Protein Interacting Protein Info
UniProt ID
BIK_HUMAN 
Synonyms BIP1; BP4; NBK
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Protein-peptide [5]
3 Yeast two hybrid [10]
4 Yeast two hybrid [11]
5 Yeast two hybrid [12]
Interacting Protein Name BH3-interacting domain death agonist (BID) Interacting Protein Interacting Protein Info
UniProt ID
BID_HUMAN 
Synonyms FP497
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [4]
3 Protein-peptide [5]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. Cell Death Differ. 1999 Jun;6(6):525-32.
REF 3 The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur J Immunol. 2002 Jul;32(7):1847-55.
REF 4 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005 Feb 4;17(3):393-403.
REF 5 Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006 May;9(5):351-65.
REF 6 Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Apoptosis. 2001 Oct;6(5):319-30.
REF 7 BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol. 1998 Sep;12(9):1432-40.
REF 8 Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins. Oncotarget. 2014 Sep 30;5(18):8452-65.
REF 9 Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins. Biochem Biophys Res Commun. 2014 Feb 28;445(1):120-5.
REF 10 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 11 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 12 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Nat Commun. 2018 Sep 14;9(1):3747.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.