Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Serine/threonine-protein kinase ATR (FRP1) | Clinical trial | Target Info | ||
| UniProt ID | ATR_HUMAN | ||||
| Gene Name | ATR | ||||
| Gene ID | 545 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Tyrosine-protein kinase ABL1 (ABL) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Checkpoint kinase-1 (CHK1) | Target Info | PPI Info | [2] | |
| ATM serine/threonine kinase (ATM) | Target Info | PPI Info | [3] | ||
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | ||
| Serine/threonine-protein kinase ATR (FRP1) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | DNA mismatch repair protein MSH2 (MSH2) | Target Info | PPI Info | [5] | |
| Gamma-Histone H2AX (H2AFX) | Target Info | PPI Info | [6] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011 Jan;18(1):5-15. | ||||
| REF 2 | Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69. | ||||
| REF 3 | ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 2006 Dec 13;25(24):5775-82. | ||||
| REF 4 | ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway. Cancer Res. 2012 Mar 1;72(5):1149-56. | ||||
| REF 5 | MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92. | ||||
| REF 6 | Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol. 2012 Feb;32(4):783-96. | ||||
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