Target Validation Information
Target ID T92072
Target Name Adenosine A1 receptor
Target Type
Successful
Drug Potency against Target Rolofylline Drug Info IC50 = 9500 nM [552871]
Tecadenoson Drug Info Ki = 6.5 nM [528068]
4-Nitro-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 22 nM [526099]
PSB-601 Drug Info Ki = 260 nM [530243]
N-(4,6-diphenylpyrimidin-2-yl)-3-methylbutyramide Drug Info Ki = 25.1 nM [527331]
LUF-5956 Drug Info Ki = 0.82 nM [528192]
5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol Drug Info Ki = 8.6 nM [528673]
LUF-5981 Drug Info IC50 = 1700 nM [528673]
N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide Drug Info Ki = 9.51 nM [530752]
2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine Drug Info Ki = 0.87 nM [528673]
9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine Drug Info Ki = 0.4 nM [527823]
ST-1535 Drug Info Ki = 71.8 nM [527823]
OSIP-339391 Drug Info Ki = 450 nM [530966]
BRL-61063 Drug Info IC50 = 170 nM [533908]
8-cyclohexyl-6-(4-tolyl)-2-phenyl-9H-purine Drug Info Ki = 36 nM [528192]
R-N6-(phenylisopropyl)adenosine Drug Info Ki = 2 nM [528748]
2-(hex-1-ynyl)-N6-methoxyadenosine Drug Info Ki = 97 nM [528684]
2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine Drug Info Ki = 253 nM [528748]
2-chloro-2'-C-methyl-tecadenoson Drug Info Ki = 67 nM [529098]
2-chloro-N6-cyclopentyladenosine Drug Info Ki = 650 nM [529098]
8-Bromo-9-(sec-butyl)-9H-adenine Drug Info Ki = 3100 nM [530014]
6-ethylamino-2-(3''-indolyl)ethyloxy)adenosine Drug Info Ki = 640 nM [528748]
2,6,8-triphenyl-9H-purine Drug Info Ki = 21 nM [528192]
2,6-diphenyl-8-ethyl-1-deazapurine Drug Info Ki = 2.4 nM [528673]
LUF-5957 Drug Info IC50 = 477 nM [528192]
N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine Drug Info Ki = 255 nM [528684]
N-(2,6-diphenylpyrimidin-4-yl)acetamide Drug Info Ki = 37.5 nM [527331]
N-(4,6-diphenylpyrimidin-2-yl)-3-chlorobenzamide Drug Info Ki = 368 nM [527331]
1-Propyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 3310 nM [526332]
N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide Drug Info Ki = 6.35 nM [527331]
LUF-5737 Drug Info Ki = 8.87 nM [527331]
2-(3''(7''-bromo-indolyl)ethyloxy)adenosine Drug Info Ki = 210 nM [528748]
2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine Drug Info Ki = 282 nM [528684]
2-phenylpropoxyadenosine Drug Info Ki = 960 nM [528748]
Tonapofylline Drug Info Ki = 1.3 nM [530752]
2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one Drug Info Ki = 29 nM [528969]
N6-((+/-)-endo-norborn-2-yl)adenosine Drug Info Ki = 0.54 nM [530035]
2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine Drug Info Ki = 358 nM [528748]
2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine Drug Info Ki = 150 nM [528748]
N-(4,6-diphenylpyrimidin-2-yl)propionamide Drug Info Ki = 46.4 nM [527331]
6-(furan-2-yl)-9H-purin-2-amine Drug Info Ki = 4951 nM [529858]
2-(4-chloro-1H-benzo[d]imidazol-2-yl)quinoxaline Drug Info Ki = 350 nM [527933]
2,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 58 nM [526099]
N6-methoxy-2-[(4-methylphenyl)ethynyl]adenosine Drug Info Ki = 1380 nM [528684]
ISOGUANOSINE Drug Info Ki = 94 nM
N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine Drug Info Ki = 730 nM [528684]
KF-17837 Drug Info IC50 = 62 nM [525962]
2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile Drug Info Ki = 12 nM [529602]
N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide Drug Info Ki = 358 nM [530694]
LUF-6258 Drug Info Ki = 651 nM [530808]
Phenyl(2-(trifluoromethyl)quinolin-4-yl)methanol Drug Info Ki = 16500 nM [529418]
4-tert-Butyl-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 1360 nM [526099]
1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 500 nM [533429]
7-Chloro-2-phenyl-[1,8]naphthyridin-4-ol Drug Info Ki = 1.62 nM [527090]
1,3-Diethyl-8-phenyl-3,7-dihydro-purine-2,6-dione Drug Info IC50 = 48 nM [533446]
2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine Drug Info Ki = 230 nM [528559]
ARISTEROMYCIN Drug Info Ki = 6260 nM [525783]
LUF-5853 Drug Info Ki = 11 nM [529299]
Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate Drug Info Ki = 72.9 nM [530752]
2,6-Diphenyl-pyrimidin-4-ylamine Drug Info Ki = 25.2 nM [529299]
2,6-diphenyl-1-deazapurine Drug Info Ki = 1.2 nM [528673]
KW-6002 Drug Info Ki = 230 nM [528835]
METHYLTHIOADENOSINE Drug Info IC50 = 15100 nM [527040]
8-Bromo-9-cyclobutyl-9H-adenine Drug Info Ki = 2200 nM [530014]
LUF-5980 Drug Info Ki = 0.61 nM [528673]
2-tolyl-6-phenyl-9H-purine Drug Info Ki = 4 nM [528192]
9-Ethyl-9H-adenine Drug Info Ki = 7400 nM [530014]
8-Bromo-9-propyl-9H-adenine Drug Info Ki = 1100 nM [530014]
8-Bromo-9-phenylethyl-9H-adenine Drug Info Ki = 12000 nM [530014]
4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine Drug Info Ki = 2765 nM [529858]
2-(4-chlorophenyl)-6-phenyl-9H-purine Drug Info Ki = 27 nM [528192]
N6-CYCLOPENTYLADENOSINE Drug Info Ki = 810 nM [529098]
2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine Drug Info Ki = 145 nM [528748]
2-(3''(5''-chloro-indolyl)ethyloxy)adenosine Drug Info Ki = 130 nM [528748]
N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine Drug Info Ki = 22 nM [528684]
3-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 86 nM [526099]
2-Amino-4,6-di-furan-2-yl-nicotinonitrile Drug Info Ki = 12 nM [529602]
2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-amine Drug Info Ki = 659 nM [528969]
5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol Drug Info Ki = 7370 nM [529305]
2,6-bis(4-tolyl)-9H-purine Drug Info Ki = 235 nM [528192]
9-Phenyl-9H-purin-6-ylamine Drug Info Ki = 19000 nM [529774]
N-(2,6-diphenylpyrimidin-4-yl)propionamide Drug Info Ki = 9.5 nM [527331]
7-Dimethylamino-2-phenyl-[1,8]naphthyridin-4-ol Drug Info Ki = 6.02 nM [527090]
N-(4,5-diphenylpyrimidin-2-yl)acetamide Drug Info Ki = 483 nM [527331]
9-Cyclopentyl-9H-adenine Drug Info Ki = 1800 nM [529774]
1-METHYLXANTHINE Drug Info Ki = 9000 nM [533429]
N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide Drug Info Ki = 14.8 nM [527331]
Cyclopentyl-(9-cyclopentyl-9H-purin-6-yl)-amine Drug Info Ki = 1200 nM [529774]
2-(6-Cyclopentylamino-purin-9-yl)-ethanol Drug Info Ki = 3300 nM [529774]
(2-Chloro-9-methyl-9H-purin-6-yl)-phenyl-amine Drug Info Ki = 7000 nM [529774]
Cyclopentyl-(9-methyl-9H-purin-6-yl)-amine Drug Info Ki = 540 nM [529774]
2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine Drug Info Ki = 45 nM [528969]
3,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 59 nM [526099]
4-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 18 nM [526099]
LUF-5767 Drug Info Ki = 2.22 nM [527331]
2-phenyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one Drug Info Ki = 203 nM [528969]
Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine Drug Info Ki = 3000 nM [527647]
N-(2,6-diphenylpyrimidin-4-yl)isobutyramide Drug Info Ki = 11.1 nM [527331]
9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine Drug Info Ki = 1280 nM [526104]
2-amino-N-benzyl-6-phenyl-9H-purine-9-carboxamide Drug Info Ki = 60 nM [529421]
LUF-5978 Drug Info Ki = 0.55 nM [528673]
2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 615 nM [529419]
2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile Drug Info Ki = 28 nM [529602]
2-Amino-4,6-diphenyl-pyrimidine Drug Info Ki = 17.7 nM [529299]
Phenyl-(9-phenyl-9H-purin-6-yl)-amine Drug Info Ki = 6900 nM [529774]
2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine Drug Info Ki = 21 nM [528969]
2-(2''-indolylethyloxy)adenosine Drug Info Ki = 197 nM [528748]
2-(4-hydroxypent-1-yl)-N6-methoxyadenosine Drug Info Ki = 95 nM [528684]
N6-methoxy-2-phenylethynyladenosine Drug Info Ki = 1210 nM [528684]
4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine Drug Info Ki = 675 nM [529419]
2-ethynyl-N6-methoxyadenosine Drug Info Ki = 25 nM [528684]
(9-Methyl-9H-purin-6-yl)-phenyl-amine Drug Info Ki = 6900 nM [529774]
N-(4,6-diphenylpyrimidin-2-yl)-2-ethylbutyramide Drug Info Ki = 27.1 nM [527331]
Hexanoic Acid (2,6-diphenylpyrimidin-4-yl)amide Drug Info Ki = 109 nM [527331]
Cyclohexyl-(9-methyl-9H-purin-6-yl)-amine Drug Info Ki = 940 nM [529774]
4-Bromo-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 33 nM [526099]
4-Methoxy-N-(3-phenyl-isoquinolin-1-yl)-benzamide Drug Info Ki = 3000 nM [526099]
Anthoptilide C Drug Info IC50 = 3100 nM [525744]
A-987306 Drug Info IC50 = 6.7 nM [529789]
N-(2,6-diphenylpyrimidin-4-yl)butyramide Drug Info Ki = 17.6 nM [527331]
LUF-5764 Drug Info Ki = 8.75 nM [527331]
N-(4-Phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 39 nM [526099]
2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline Drug Info Ki = 8000 nM [529313]
4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzamide Drug Info Ki = 36 nM [526099]
N-(2,6-diphenylpyrimidin-4-yl)benzamide Drug Info Ki = 671 nM [527331]
N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine Drug Info Ki = 437 nM [528684]
9-benzyl-6-(furan-2-yl)-9H-purin-2-amine Drug Info Ki = 3324 nM [529421]
N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine Drug Info Ki = 2730 nM [527647]
1H-Imidazo[4,5-c]quinolin-4-ylamine HCl Drug Info Ki = 1600 nM [530590]
2-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 3205 nM [529419]
Cyclopentyl-(9-phenyl-9H-purin-6-yl)-amine Drug Info Ki = 8700 nM [529774]
SCH-63390 Drug Info Ki = 504 nM [534646]
Kuanoniamine D Drug Info Ki = 2940 nM [534583]
3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione Drug Info Ki = 50 nM [533542]
7-Methyl-2-propyl-[1,8]naphthyridin-4-ol Drug Info Ki = 61.5 nM [527090]
9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine Drug Info Ki = 4027 nM [529421]
9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine Drug Info Ki = 3920 nM [529421]
L-249313 Drug Info IC50 = 5300 nM [525962]
Caffeine Drug Info IC50 = 107000 nM [553106]
SB-298 Drug Info Ki = 35 nM [530243]
2,6-dphenyl-8-propyl-1-deazapurine Drug Info Ki = 2.5 nM [528673]
GNF-PF-2700 Drug Info Ki = 1330 nM [530966]
8-bromo-9-isobutyl-9H-purin-6-amine Drug Info Ki = 4900 nM [530966]
FK-453 Drug Info IC50 = 17.2 nM [530752]
8-Bromo-9-(but-3-enyl)-9H-adenine Drug Info Ki = 4900 nM [530014]
8-Bromo-9-(2-hydroxypropyl)-9H-adenine Drug Info Ki = 2900 nM [530014]
9-Benzyl-8-bromo-9H-adenine Drug Info Ki = 6700 nM [530014]
9-Cyclobutyl-9H-adenine Drug Info Ki = 8700 nM [530014]
2'-Me-tecadenoson Drug Info Ki = 150 nM [529098]
9-Allyl-8-bromo-9H-adenine Drug Info Ki = 8400 nM [530014]
1,3-Diethyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 3300 nM [533429]
2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile Drug Info Ki = 22 nM [529602]
2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 2041 nM [529419]
(1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl Drug Info Ki = 2100 nM [530590]
CIRSIMARIN Drug Info Ki = 3200 nM [534416]
2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine Drug Info Ki = 34 nM [530590]
GW-328267 Drug Info Ki = 369 nM [527144]
2,6-diphenyl-9H-purine Drug Info Ki = 4.1 nM [528192]
3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one Drug Info Ki = 3336 nM [529313]
VUF-8507 Drug Info Ki = 3200 nM [525784]
LUF-5433 Drug Info Ki = 76 nM [530752]
1,3-Dipropyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 700 nM [533429]
8-Bromo-9-cyclohexyl-9H-adenine Drug Info Ki = 4600 nM [530014]
LUF-5417 Drug Info Ki = 32 nM [530752]
8-Bromo-9-(2-butyl)-9H-adenine Drug Info Ki = 3200 nM [530014]
8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine Drug Info Ki = 16000 nM [530014]
LUF-5962 Drug Info Ki = 0.29 nM [528192]
2-(4-methoxyphenyl)-6-phenyl-9H-purine Drug Info Ki = 32 nM [528192]
8-Bromo-9-isopropyl-9H-adenine Drug Info Ki = 830 nM [530014]
8-Bromo-9-cyclopentyl-9H-adenine Drug Info Ki = 1000 nM [530014]
8-Bromo-9-(3-hydroxypropyl)-9H-adenine Drug Info Ki = 1000 nM [530014]
8-Bromo-9-ethyl-9H-adenine Drug Info Ki = 280 nM [530014]
9-Propyl-9H-adenine Drug Info Ki = 9400 nM [530014]
2-Amino-4,6-diphenyl-pyrimidin-5-carbonitrile Drug Info Ki = 3.3 nM [529299]
9-Isopropyl-9H-adenine Drug Info Ki = 4300 nM [530014]
8-Bromo-9-methyl-9H-adenine Drug Info Ki = 570 nM [530014]
2,6-dimethyl-8-ethyl-1-deazapurine Drug Info Ki = 101 nM [528673]
2,6-diphenyl-8-methyl-1-deazapurine Drug Info Ki = 14 nM [528673]
3-noradamantyl-1,3-dipropylxanthine Drug Info Ki = 8 nM [528544]
2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile Drug Info Ki = 5.8 nM [529602]
7-Bromo-2-phenyl-[1,8]naphthyridin-4-ol Drug Info Ki = 1.6 nM [527090]
2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine Drug Info Ki = 1.56 nM [530035]
N-(4,6-diphenylpyrimidin-2-yl)benzamide Drug Info Ki = 309 nM [527331]
2-(1H-benzo[d]imidazol-2-yl)quinoxaline Drug Info Ki = 50 nM [529313]
2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine Drug Info Ki = 270 nM [530590]
3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol Drug Info Ki = 8720 nM [527683]
1,3-Diallyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 10000 nM [533429]
2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile Drug Info Ki = 43 nM [529602]
LUF-5816 Drug Info Ki = 0.62 nM [528673]
2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine Drug Info Ki = 2790 nM [528684]
2-(3''-indolylethyloxy)adenosine Drug Info Ki = 148 nM [528748]
3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol Drug Info Ki = 4180 nM [527683]
2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine Drug Info Ki = 350 nM [528748]
N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine Drug Info Ki = 1870 nM [528684]
2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine Drug Info Ki = 1820 nM [528748]
2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine Drug Info Ki = 310 nM [528748]
2-(3''-pyrrolylethyloxy)adenosine Drug Info Ki = 218 nM [528748]
2-ethyl-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 1466 nM [529419]
6-guanidino-2-(3''-indolylethyloxy)adenosine Drug Info Ki = 73.6 nM [528748]
2-Amino-4,6-diphenyl-nicotinonitrile Drug Info Ki = 14 nM [529602]
N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine Drug Info Ki = 1190 nM [528684]
2-ethyl-4-(furan-3-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 10000 nM [529419]
2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine Drug Info Ki = 1280 nM [528684]
2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 917 nM [529419]
2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine Drug Info Ki = 388 nM [529419]
Pentanoic acid (4,6-diphenylpyrimidin-2-yl)amide Drug Info Ki = 27.6 nM [527331]
PD-81723 Drug Info Ki = 11000 nM [529655]
8-PHENYL THEOPHYLLINE Drug Info Ki = 37 nM [530590]
LUF-5735 Drug Info Ki = 3.7 nM [527331]
2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine Drug Info Ki = 443 nM [528748]
4-Chloro-7-methyl-2-phenyl-[1,8]naphthyridine Drug Info Ki = 1000 nM [525857]
P-IODOAMPHETAMINE Drug Info Ki = 1.2 nM [526824]
2-(4-ethylthiobenzimidazol-2-yl)quinoxaline Drug Info Ki = 0.5 nM [527933]
FK-838 Drug Info Ki = 6.61 nM [530752]
CVT-6883 Drug Info Ki = 1940 nM [530243]
2-(6-amino-8-bromo-9H-purin-9-yl)ethanol Drug Info Ki = 1500 nM [530966]
METRIFUDIL Drug Info Ki = 98 nM [525578]
2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine Drug Info Ki = 56 nM [529255]
PD-115199 Drug Info Ki = 13.9 nM [527717]
4-Amino-2,6-diphenyl-pyrimidine-5-carbonitrile Drug Info Ki = 10.8 nM [529299]
N6-[(4-Nitro)-phenyl]-9-benzyl-2-phenyladenine Drug Info Ki = 571 nM [529183]
N6-[(4-Amino)-phenyl]-9-benzyl-2-phenyladenine Drug Info Ki = 294 nM [529183]
CVT-124 Drug Info Ki = 0.45 nM [552326]
Cyclopentyl-(9-ethyl-9H-purin-6-yl)-amine Drug Info Ki = 440 nM [529774]
Cyclohexyl-(9-ethyl-9H-purin-6-yl)-amine Drug Info Ki = 2000 nM [529774]
SCH-442416 Drug Info Ki = 1815 nM [525917]
PSB-0788 Drug Info Ki = 386 nM [530243]
FR-166124 Drug Info IC50 = 15 nM [525562]
8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 67 nM [533940]
2,6-diphenyl-8-tButyl-1-deazapurine Drug Info Ki = 5.5 nM [528673]
4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine Drug Info Ki = 479 nM [529421]
ZM-241385 Drug Info Ki = 180 nM [530372]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info Ki < 1000 nM [531079]
VCP-28 Drug Info Ki = 50 nM [530849]
1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 130 nM [533339]
NECA Drug Info Ki = 8.2 nM [533449]
N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine Drug Info Ki = 4470 nM [527647]
9-Methyl-9H-adenine Drug Info IC50 = 14700 nM [527040]
2-amino-6-phenyl-4-p-tolylnicotinonitrile Drug Info Ki = 274 nM [528434]
4-(ethylthio)-6-phenyl-1,3,5-triazin-2-amine Drug Info Ki = 67 nM [528434]
9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine Drug Info Ki = 5765 nM [529421]
8-Phenyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 2500 nM [533940]
GNF-PF-2224 Drug Info Ki = 0.5 nM [530672]
1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione Drug Info Ki = 40 nM [526958]
2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one Drug Info Ki = 12 nM [528969]
8-propyl-2,6-diphenyl-9H-purine Drug Info Ki = 4.4 nM [528192]
References
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Ref 527823J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
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