| Drug General Information |
| Drug ID |
D09UDF
|
| Former ID |
DNC008467
|
| Drug Name |
2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H5ClN2S2
|
| Canonical SMILES |
C1=CSC(=C1)C2=NC(=NC3=C2SC=C3)Cl
|
| InChI |
1S/C10H5ClN2S2/c11-10-12-6-3-5-15-9(6)8(13-10)7-2-1-4-14-7/h1-5H
|
| InChIKey |
GFDPXLUZWJSHBL-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
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Calcium signaling pathway
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Vascular smooth muscle contraction
|
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Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
|
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
|
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PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
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NGF-independant TRKA activation
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Adenosine P1 receptors
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling events
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WikiPathways
|
Nucleotide GPCRs
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Monoamine Transport
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GPCRs, Class A Rhodopsin-like
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. Epub 2008 Mar 30.Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. |
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