| Drug General Information |
| Drug ID |
D0OX0V
|
| Former ID |
DNC005883
|
| Drug Name |
2-(4-ethylthiobenzimidazol-2-yl)quinoxaline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H14N4S
|
| Canonical SMILES |
CCSC1=CC=CC2=C1N=C(N2)C3=NC4=CC=CC=C4N=C3
|
| InChI |
1S/C17H14N4S/c1-2-22-15-9-5-8-13-16(15)21-17(20-13)14-10-18-11-6-3-4-7-12(11)19-14/h3-10H,2H2,1H3,(H,20,21)
|
| InChIKey |
IHVQPVYBIZVMSJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Vascular smooth muscle contraction
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Parkinson's disease
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Reactome
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NGF-independant TRKA activation
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Adenosine P1 receptors
|
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
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G alpha (i) signalling events
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WikiPathways
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Nucleotide GPCRs
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Monoamine Transport
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GPCRs, Class A Rhodopsin-like
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCR downstream signalingWP80:Nucleotide GPCRs
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|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 2005 Dec 29;48(26):8253-60.2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. |
|---|
