| Drug General Information |
| Drug ID |
D05XGF
|
| Former ID |
DNC009732
|
| Drug Name |
PSB-0788
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C25H27ClN6O4S
|
| InChI |
InChI=1S/C25H27ClN6O4S/c1-2-11-32-24(33)21-23(29-25(32)34)28-22(27-21)18-5-9-20(10-6-18)37(35,36)31-14-12-30(13-15-31)16-17-3-7-19(26)8-4-17/h3-10H,2,11-16H2,1H3,(H,27,28)(H,29,34)
|
| InChIKey |
JQZJACVYMPKVDS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
85181996, 89946523, 103633633, 104114695, 134346937, 135698687, 178103175, 241020220, 241376306, 249617779, 252157087
|
| Target and Pathway |
| Target(s) |
Adenosine A1 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[2]
|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
|
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Neuroactive ligand-receptor interaction
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Morphine addictionhsa04015:Rap1 signaling pathway
|
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Calcium signaling pathway
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Vascular smooth muscle contraction
|
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Parkinson's disease
|
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Alcoholismhsa04015:Rap1 signaling pathway
|
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Alcoholism
|
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NetPath Pathway
|
TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
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HIF-2-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
|
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and AdenosinePW000446:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
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Reactome
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Adenosine P1 receptors
|
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G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
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Surfactant metabolism
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WikiPathways
|
Nucleotide GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6561). |
|---|
| REF 2 | J Med Chem. 2009 Jul 9;52(13):3994-4006.1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. |
|---|
