| Drug General Information |
| Drug ID |
D02BGA
|
| Former ID |
DNC005806
|
| Drug Name |
9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H8N8
|
| Canonical SMILES |
CN1C2=C(C(=NC=N2)N)N=C1N3N=CC=N3
|
| InChI |
1S/C8H8N8/c1-15-7-5(6(9)10-4-11-7)14-8(15)16-12-2-3-13-16/h2-4H,1H3,(H2,9,10,11)
|
| InChIKey |
ZTJZVOMEMRNYKF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
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Vascular smooth muscle contraction
|
|
Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
|
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NetPath Pathway
|
TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
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PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
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NGF-independant TRKA activation
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Adenosine P1 receptors
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling events
|
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WikiPathways
|
Nucleotide GPCRs
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Monoamine Transport
|
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GPCRs, Class A Rhodopsin-like
|
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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GPCR downstream signaling
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|
GPCRs, OtherWP80:Nucleotide GPCRs
|
| References |
| REF 1 | J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
|---|
