| Drug General Information |
| Drug ID |
D04WHE
|
| Former ID |
DNC008807
|
| Drug Name |
9-Propyl-9H-adenine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H11N5
|
| Canonical SMILES |
CCCN1C=NC2=C1N=CN=C2N
|
| InChI |
1S/C8H11N5/c1-2-3-13-5-12-6-7(9)10-4-11-8(6)13/h4-5H,2-3H2,1H3,(H2,9,10,11)
|
| InChIKey |
QTULKOMMYIUZQD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Parkinson's disease
|
|
Alcoholismhsa04015:Rap1 signaling pathway
|
|
Alcoholismhsa04022:cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
RANKL Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
HIF-2-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and AdenosinePW000446:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
NGF-independant TRKA activation
|
|
Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
|
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
Monoamine Transport
|
|
GPCRs, Class A Rhodopsin-like
|
|
NGF signalling via TRKA from the plasma membrane
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
|
GPCR downstream signalingWP80:Nucleotide GPCRs
|
| References |
| REF 1 | Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
|---|
