| Drug General Information |
| Drug ID |
D00JWA
|
| Former ID |
DNC010621
|
| Drug Name |
N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H13N3O2
|
| Canonical SMILES |
CC(=O)NC1=NC(=C(C=C1)C2=CC=NC=C2)C3=CC=CO3
|
| InChI |
1S/C16H13N3O2/c1-11(20)18-15-5-4-13(12-6-8-17-9-7-12)16(19-15)14-3-2-10-21-14/h2-10H,1H3,(H,18,19,20)
|
| InChIKey |
STFZQXRQDWXSGW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interaction
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Morphine addictionhsa04015:Rap1 signaling pathway
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Calcium signaling pathway
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Vascular smooth muscle contraction
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Alcoholismhsa04015:Rap1 signaling pathway
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Parkinson's disease
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Reactome
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Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling events
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WikiPathways
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Nucleotide GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCRs, Other
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. Epub 2010 Jan 20.Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. |
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