| Drug General Information |
| Drug ID |
D0E8RA
|
| Former ID |
DNC008824
|
| Drug Name |
8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H10BrN5O2
|
| Canonical SMILES |
C1=NC2=C(C(=N1)N)N=C(N2CC(CO)O)Br
|
| InChI |
1S/C8H10BrN5O2/c9-8-13-5-6(10)11-3-12-7(5)14(8)1-4(16)2-15/h3-4,15-16H,1-2H2,(H2,10,11,12)
|
| InChIKey |
XXTHNUCUAMMCPB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
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Alcoholismhsa04015:Rap1 signaling pathway
|
|
cAMP signaling pathway
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Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
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Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
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C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
|
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
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Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
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Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
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G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
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Monoamine Transport
|
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NGF signalling via TRKA from the plasma membrane
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GPCR downstream signaling
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
| References |
| REF 1 | Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
|---|
