| Drug General Information |
| Drug ID |
D0B3NZ
|
| Former ID |
DNC010468
|
| Drug Name |
N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H16N2O2S
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=C(SC(=N2)NC(=O)C3=CC=CC=C3)C(=O)C4=CC=C<br />C=C4
|
| InChI |
1S/C23H16N2O2S/c26-20(17-12-6-2-7-13-17)21-19(16-10-4-1-5-11-16)24-23(28-21)25-22(27)18-14-8-3-9-15-18/h1-15H,(H,24,25,27)
|
| InChIKey |
PCQHQQZQXRSVDE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interaction
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Morphine addictionhsa04015:Rap1 signaling pathway
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Calcium signaling pathway
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Vascular smooth muscle contraction
|
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Parkinson's disease
|
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Alcoholism
|
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NetPath Pathway
|
TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
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Adenosine P1 receptors
|
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
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G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
|
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G alpha (s) signalling events
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Surfactant metabolism
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WikiPathways
|
Nucleotide GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR downstream signaling
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GPCRs, Other
|
| References |
| REF 1 | Bioorg Med Chem. 2010 Mar 15;18(6):2195-203. Epub 2010 Feb 4.2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. |
|---|
