Drug General Information
Drug ID	D0W8RB
Former ID	DNC008814
Drug Name	8-Bromo-9-(but-3-enyl)-9H-adenine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[1]
Structure		Download 2D MOL 3D MOL
Formula	C9H10BrN5
Canonical SMILES	C=CCCN1C2=C(C(=NC=N2)N)N=C1Br
InChI	1S/C9H10BrN5/c1-2-3-4-15-8-6(14-9(15)10)7(11)12-5-13-8/h2,5H,1,3-4H2,(H2,11,12,13)
InChIKey	PZPGDJLTSOBNOR-UHFFFAOYSA-N
PubChem Compound ID	44572357
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Inhibitor	[1]
	Adenosine A2a receptor	Target Info	Inhibitor	[1]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addictionhsa04015:Rap1 signaling pathway
	Calcium signaling pathway
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	Adenosine P1 receptors
	G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP80:Nucleotide GPCRs
	Monoamine Transport
	NGF signalling via TRKA from the plasma membrane
	GPCR downstream signaling
	GPCRs, Other
References
REF 1	Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.

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