| Drug General Information |
| Drug ID |
D01LWZ
|
| Former ID |
DNC008111
|
| Drug Name |
2-chloro-N6-cyclopentyladenosine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C15H20ClN5O4
|
| InChI |
InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
|
| InChIKey |
XSMYYYQVWPZWIZ-IDTAVKCVSA-N
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| PubChem Compound ID |
|
| PubChem Substance ID |
7978870, 10240867, 14926452, 15077639, 24892583, 26752235, 29303998, 47583681, 47657043, 47880040, 47954406, 48253885, 48253886, 49865076, 51243784, 57340594, 81044344, 85177284, 91703424, 103212393, 103985068, 104419371, 126660210, 129734712, 134345316, 135079214, 135651141, 135651453, 135697905, 141602533, 162093815, 162130926, 163410111, 163848507, 164823195, 184566468, 202562977, 223556784, 223669070, 223987835, 226492042, 241066841, 252156050, 252215107, 252361355, 252485774
|
| Target and Pathway |
| Target(s) |
Adenosine A1 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[2]
|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[2]
|
| Adenosine A3 receptor |
Target Info |
Inhibitor |
[2]
|
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KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interaction
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Morphine addictionhsa04015:Rap1 signaling pathway
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Calcium signaling pathway
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Vascular smooth muscle contraction
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Alcoholismhsa04015:Rap1 signaling pathway
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Parkinson's disease
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Reactome
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Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling events
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WikiPathways
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Nucleotide GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCRs, Other
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 374). |
|---|
| REF 2 | Bioorg Med Chem. 2008 Jan 1;16(1):336-53. Epub 2007 Sep 22.5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivityfor A1 receptor from different species. |
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