| Drug General Information |
| Drug ID |
D0B0TX
|
| Former ID |
DNC008812
|
| Drug Name |
8-bromo-9-isobutyl-9H-purin-6-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H12BrN5
|
| Canonical SMILES |
CC(C)CN1C2=C(C(=NC=N2)N)N=C1Br
|
| InChI |
1S/C9H12BrN5/c1-5(2)3-15-8-6(14-9(15)10)7(11)12-4-13-8/h4-5H,3H2,1-2H3,(H2,11,12,13)
|
| InChIKey |
RLPKQFORPDRBQT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Alcoholismhsa04015:Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
|
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Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
RANKL Signaling Pathway
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
|
C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
|
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PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
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G alpha (s) signalling events
|
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Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
|
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
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Monoamine Transport
|
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NGF signalling via TRKA from the plasma membrane
|
|
GPCR downstream signaling
|
| References |
| REF 1 | Eur J Med Chem. 2010 Aug;45(8):3459-71. Epub 2010 May 7.Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. |
|---|
