Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T83011
(Former ID: TTDS00341)
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| Target Name |
Monoamine oxidase type B (MAO-B)
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| Synonyms |
MAO-B; Amine oxidase [flavin-containing] B
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| Gene Name |
MAOB
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| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 6 Target-related Diseases | + | ||||
| 1 | Dementia [ICD-11: 6D80-6D8Z] | |||||
| 2 | Depression [ICD-11: 6A70-6A7Z] | |||||
| 3 | Hypertension [ICD-11: BA00-BA04] | |||||
| 4 | Malaria [ICD-11: 1F40-1F45] | |||||
| 5 | Migraine [ICD-11: 8A80] | |||||
| 6 | Parkinsonism [ICD-11: 8A00] | |||||
| Function |
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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| BioChemical Class |
CH-NH(2) donor oxidoreductase
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| UniProt ID | ||||||
| EC Number |
EC 1.4.3.4
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| Sequence |
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| HIT2.0 ID | T06Q1R | |||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 11 Approved Drugs | + | ||||
| 1 | Budipine | Drug Info | Approved | Migraine | [2] | |
| 2 | Indeloxazine | Drug Info | Approved | Dementia | [3] | |
| 3 | Pargyline | Drug Info | Approved | Hypertension | [3] | |
| 4 | Phenelzine | Drug Info | Approved | Depression | [3], [4], [5] | |
| 5 | Rasagiline | Drug Info | Approved | Parkinson disease | [6], [7] | |
| 6 | Safinamide | Drug Info | Approved | Parkinson disease | [8] | |
| 7 | Safinamide mesylate | Drug Info | Approved | Parkinson disease | [9] | |
| 8 | Selegiline | Drug Info | Approved | Major depressive disorder | [10], [11] | |
| 9 | Selegiline Hydrochloride | Drug Info | Approved | Parkinson disease | [3] | |
| 10 | Sulphadoxine | Drug Info | Approved | Malaria | [12], [13] | |
| 11 | Tranylcypromine | Drug Info | Approved | Major depressive disorder | [3] | |
| Clinical Trial Drug(s) | [+] 9 Clinical Trial Drugs | + | ||||
| 1 | P2B-001 | Drug Info | Phase 3 | Parkinson disease | [14] | |
| 2 | CHF-3381 | Drug Info | Phase 2 | Neuropathic pain | [15], [16] | |
| 3 | EVT302 | Drug Info | Phase 2 | Alzheimer disease | [14], [17] | |
| 4 | Ladostigil | Drug Info | Phase 2 | Alzheimer disease | [18] | |
| 5 | ORY-2001 | Drug Info | Phase 2 | Alzheimer disease | [19] | |
| 6 | RG1577 | Drug Info | Phase 2 | Alzheimer disease | [20] | |
| 7 | Neu-120 | Drug Info | Phase 1/2 | Parkinson disease | [21] | |
| 8 | PIPERINE | Drug Info | Phase 1/2 | Vitiligo | [22], [23] | |
| 9 | PF9601N | Drug Info | Phase 1 | Parkinson disease | [24] | |
| Patented Agent(s) | [+] 3 Patented Agents | + | ||||
| 1 | Lazabemide | Drug Info | Patented | Skin imperfections | [25] | |
| 2 | Schiff base compound 1 | Drug Info | Patented | Alzheimer disease | [26] | |
| 3 | Schiff base compound 2 | Drug Info | Patented | Alzheimer disease | [26] | |
| Discontinued Drug(s) | [+] 6 Discontinued Drugs | + | ||||
| 1 | MOFEGILINE | Drug Info | Discontinued in Phase 3 | Cognitive impairment | [27] | |
| 2 | AS602868 | Drug Info | Discontinued in Phase 1 | Multiple myeloma | [28] | |
| 3 | EVT-301 | Drug Info | Discontinued in Phase 1 | Alzheimer disease | [29] | |
| 4 | HT-1067 | Drug Info | Discontinued in Phase 1 | Parkinson disease | [30] | |
| 5 | SL-25.1188 | Drug Info | Discontinued in Phase 1 | Alzheimer disease | [31] | |
| 6 | Milacemide | Drug Info | Terminated | Alzheimer disease | [33] | |
| Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
| 1 | RWJ-416457 | Drug Info | Preclinical | Bacterial infection | [32] | |
| Mode of Action | [+] 3 Modes of Action | + | ||||
| Modulator | [+] 12 Modulator drugs | + | ||||
| 1 | Budipine | Drug Info | [2] | |||
| 2 | Indeloxazine | Drug Info | [3] | |||
| 3 | Selegiline Hydrochloride | Drug Info | [38], [40] | |||
| 4 | RG1577 | Drug Info | [47] | |||
| 5 | Neu-120 | Drug Info | [48] | |||
| 6 | Tetra-hydro-oxazolopyridine derivative 1 | Drug Info | [55] | |||
| 7 | Tetra-hydro-oxazolopyridine derivative 2 | Drug Info | [55] | |||
| 8 | MOFEGILINE | Drug Info | [56], [57] | |||
| 9 | Milacemide | Drug Info | [33] | |||
| 10 | 4-fluoroselegiline | Drug Info | [88] | |||
| 11 | LU-53439 | Drug Info | [100] | |||
| 12 | VAR-10200 | Drug Info | [39] | |||
| Inhibitor | [+] 322 Inhibitor drugs | + | ||||
| 1 | Pargyline | Drug Info | [34] | |||
| 2 | Phenelzine | Drug Info | [35] | |||
| 3 | Rasagiline | Drug Info | [36] | |||
| 4 | Safinamide | Drug Info | [37], [38] | |||
| 5 | Safinamide mesylate | Drug Info | [9] | |||
| 6 | Selegiline | Drug Info | [39] | |||
| 7 | Sulphadoxine | Drug Info | [41] | |||
| 8 | Tranylcypromine | Drug Info | [1], [42] | |||
| 9 | P2B-001 | Drug Info | [43] | |||
| 10 | Psoralen | Drug Info | [44] | |||
| 11 | TRYPTAMINE | Drug Info | [45] | |||
| 12 | CHF-3381 | Drug Info | [16] | |||
| 13 | EVT302 | Drug Info | [14], [17] | |||
| 14 | Ladostigil | Drug Info | [18] | |||
| 15 | ORY-2001 | Drug Info | [46] | |||
| 16 | PIPERINE | Drug Info | [49] | |||
| 17 | PF9601N | Drug Info | [50] | |||
| 18 | 3,4-Dihydroxybenzaldehyde | Drug Info | [25] | |||
| 19 | 3-Hydroxy-2-butanone | Drug Info | [25] | |||
| 20 | 4-Hydroxy-2,5-dimethyl-3(2H)-furanone | Drug Info | [25] | |||
| 21 | 4-hydroxybenzaldehyde | Drug Info | [25] | |||
| 22 | 4-Hydroxybenzoicacid | Drug Info | [25] | |||
| 23 | 4-Hydroxybenzylalcohol | Drug Info | [25] | |||
| 24 | 4-Methoxybenzaldehyde | Drug Info | [25] | |||
| 25 | Benzylcinnamate | Drug Info | [25] | |||
| 26 | Coumaricacid | Drug Info | [25] | |||
| 27 | Coumarin/resveratrol hybrid derivative 1 | Drug Info | [26] | |||
| 28 | Coumarin/resveratrol hybrid derivative 2 | Drug Info | [26] | |||
| 29 | Cyclic peptide derivative 1 | Drug Info | [51] | |||
| 30 | Ethylvanillin | Drug Info | [25] | |||
| 31 | EUGENOL | Drug Info | [25] | |||
| 32 | FERULIC ACID | Drug Info | [25] | |||
| 33 | Heteroaryl-cyclopropylamine derivative 1 | Drug Info | [51] | |||
| 34 | Heteroaryl-cyclopropylamine derivative 3 | Drug Info | [51] | |||
| 35 | Lazabemide | Drug Info | [52], [53] | |||
| 36 | Lazabemide analog 1 | Drug Info | [26] | |||
| 37 | N-(2-phenylcyclopropyl) amino acid derivative 1 | Drug Info | [51] | |||
| 38 | N-(2-phenylcyclopropyl) amino acid derivative 3 | Drug Info | [51] | |||
| 39 | Piperonal | Drug Info | [25] | |||
| 40 | PMID25399762-Compound-Table 6-10 | Drug Info | [25] | |||
| 41 | PMID25399762-Compound-Table 6-11 | Drug Info | [25] | |||
| 42 | PMID25399762-Compound-Table 6-12 | Drug Info | [25] | |||
| 43 | PMID25399762-Compound-Table 6-13 | Drug Info | [25] | |||
| 44 | PMID25399762-Compound-Table 6-14 | Drug Info | [25] | |||
| 45 | PMID25399762-Compound-Table 6-15 | Drug Info | [25] | |||
| 46 | PMID25399762-Compound-Table 6-9 | Drug Info | [25] | |||
| 47 | PMID25399762-Compound-Table 7-Vanillic acid | Drug Info | [25] | |||
| 48 | PMID25399762-Compound-Table 7-Vanillyl alcohol | Drug Info | [25] | |||
| 49 | PMID25399762-Compound-Table 7-Veratraldehyde | Drug Info | [25] | |||
| 50 | PMID25399762-Compound-Table1-C1 | Drug Info | [25] | |||
| 51 | PMID25399762-Compound-Table1-C10 | Drug Info | [25] | |||
| 52 | PMID25399762-Compound-Table1-C11 | Drug Info | [25] | |||
| 53 | PMID25399762-Compound-Table1-C12 | Drug Info | [25] | |||
| 54 | PMID25399762-Compound-Table1-C13 | Drug Info | [25] | |||
| 55 | PMID25399762-Compound-Table1-C14 | Drug Info | [25] | |||
| 56 | PMID25399762-Compound-Table1-C15 | Drug Info | [25] | |||
| 57 | PMID25399762-Compound-Table1-C16 | Drug Info | [25] | |||
| 58 | PMID25399762-Compound-Table1-C17 | Drug Info | [25] | |||
| 59 | PMID25399762-Compound-Table1-C18 | Drug Info | [25] | |||
| 60 | PMID25399762-Compound-Table1-C19 | Drug Info | [25] | |||
| 61 | PMID25399762-Compound-Table1-C2 | Drug Info | [25] | |||
| 62 | PMID25399762-Compound-Table1-C20 | Drug Info | [25] | |||
| 63 | PMID25399762-Compound-Table1-C21 | Drug Info | [25] | |||
| 64 | PMID25399762-Compound-Table1-C22 | Drug Info | [25] | |||
| 65 | PMID25399762-Compound-Table1-C23 | Drug Info | [25] | |||
| 66 | PMID25399762-Compound-Table1-C24 | Drug Info | [25] | |||
| 67 | PMID25399762-Compound-Table1-C25 | Drug Info | [25] | |||
| 68 | PMID25399762-Compound-Table1-C3 | Drug Info | [25] | |||
| 69 | PMID25399762-Compound-Table1-C4 | Drug Info | [25] | |||
| 70 | PMID25399762-Compound-Table1-C5 | Drug Info | [25] | |||
| 71 | PMID25399762-Compound-Table1-C6 | Drug Info | [25] | |||
| 72 | PMID25399762-Compound-Table1-C7 | Drug Info | [25] | |||
| 73 | PMID25399762-Compound-Table1-C8 | Drug Info | [25] | |||
| 74 | PMID25399762-Compound-Table1-C9 | Drug Info | [25] | |||
| 75 | PMID29324067-Compound-38 | Drug Info | [26] | |||
| 76 | PMID29324067-Compound-40 | Drug Info | [26] | |||
| 77 | PMID29757691-Compound-4 | Drug Info | [54] | |||
| 78 | Secondary and tertiary (hetero)arylamide derivative 1 | Drug Info | [26] | |||
| 79 | T83193 | Drug Info | [25] | |||
| 80 | Tarnylcypromine derivative 2 | Drug Info | [51] | |||
| 81 | Tarnylcypromine derivative 3 | Drug Info | [51] | |||
| 82 | Tetra-hydro-isoquinoline derivative 1 | Drug Info | [54] | |||
| 83 | Tetra-hydro-isoquinoline derivative 2 | Drug Info | [54] | |||
| 84 | Tetra-hydro-isoquinoline derivative 3 | Drug Info | [54] | |||
| 85 | Tetra-hydro-isoquinoline derivative 4 | Drug Info | [54] | |||
| 86 | AS602868 | Drug Info | [44] | |||
| 87 | EVT-301 | Drug Info | [58] | |||
| 88 | HT-1067 | Drug Info | [59] | |||
| 89 | SL-25.1188 | Drug Info | [60] | |||
| 90 | RWJ-416457 | Drug Info | [39] | |||
| 91 | (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholin-5-one | Drug Info | [61] | |||
| 92 | (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine | Drug Info | [61] | |||
| 93 | (+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one | Drug Info | [61] | |||
| 94 | (+/-)-2-(4'-Butoxyphenyl)thiomorpholine | Drug Info | [61] | |||
| 95 | (+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one | Drug Info | [61] | |||
| 96 | (+/-)-2-(4'-Ethoxyphenyl)thiomorpholine | Drug Info | [61] | |||
| 97 | (+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one | Drug Info | [61] | |||
| 98 | (+/-)-2-(4'-Methoxyphenyl)thiomorpholine | Drug Info | [61] | |||
| 99 | (+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one | Drug Info | [61] | |||
| 100 | (+/-)-2-(4'-Propoxyphenyl)thiomorpholine | Drug Info | [61] | |||
| 101 | (+/-)-2-(4-fluorophenyl)-7-methoxychroman-4-one | Drug Info | [62] | |||
| 102 | (+/-)-2-(4-fluorophenyl)-7-methylchroman-4-one | Drug Info | [62] | |||
| 103 | (+/-)-2-(4-fluorophenyl)chroman-4-one | Drug Info | [62] | |||
| 104 | (+/-)-2-(4-methoxyphenyl)-7-methylchroman-4-one | Drug Info | [62] | |||
| 105 | (+/-)-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 106 | (+/-)-2-Phenylthiomorpholin-5-one | Drug Info | [61] | |||
| 107 | (+/-)-2-Phenylthiomorpholine | Drug Info | [61] | |||
| 108 | (+/-)-7-fluoro-2-(4-fluorophenyl)chroman-4-one | Drug Info | [62] | |||
| 109 | (+/-)-7-fluoro-2-(4-methoxyphenyl)chroman-4-one | Drug Info | [62] | |||
| 110 | (+/-)-7-fluoro-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 111 | (+/-)-7-fluoro-2-phenylchroman-4-one | Drug Info | [62] | |||
| 112 | (+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one | Drug Info | [62] | |||
| 113 | (+/-)-7-methoxy-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 114 | (+/-)-7-methoxy-2-phenylchroman-4-one | Drug Info | [62] | |||
| 115 | (+/-)-7-methyl-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 116 | (+/-)-7-methyl-2-phenylchroman-4-one | Drug Info | [62] | |||
| 117 | (6-Benzyloxy-2-naphthyl)-2-aminopropane | Drug Info | [63] | |||
| 118 | (6-Ethoxy-2-naphthyl)-2-aminopropane | Drug Info | [63] | |||
| 119 | (6-Methoxy-2-naphthyl)-2-aminopropane | Drug Info | [63] | |||
| 120 | (6-Propoxy-2-naphthyl)-2-aminopropane | Drug Info | [63] | |||
| 121 | (7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile | Drug Info | [64] | |||
| 122 | (E)-5-(3-Chlorostyryl)isatin | Drug Info | [65] | |||
| 123 | (E)-5-(3-Fluorostyryl)isatin | Drug Info | [65] | |||
| 124 | (E)-5-Styrylisatin | Drug Info | [65] | |||
| 125 | (E)-6-Styrylisatin | Drug Info | [65] | |||
| 126 | (E)-8-(3-chlorostyryl)-caffeine | Drug Info | [66] | |||
| 127 | (R)(+)-2-(4-fluorophenyl)-7-methoxychroman-4-one | Drug Info | [62] | |||
| 128 | (R)(+)-7-fluoro-2-(4-fluorophenyl)chroman-4-one | Drug Info | [62] | |||
| 129 | (R)(+)-7-fluoro-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 130 | (R)(+)-7-fluoro-2-phenylchroman-4-one | Drug Info | [62] | |||
| 131 | (R)(+)-7-methyl-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 132 | (R)(+)-7-methyl-2-phenylchroman-4-one | Drug Info | [62] | |||
| 133 | (R)-3-Prop-2-ynylamino-indan-5-ol | Drug Info | [53], [67] | |||
| 134 | (R)-Indan-1-yl-methyl-prop-2-ynyl-amine | Drug Info | [53] | |||
| 135 | (R)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide | Drug Info | [68] | |||
| 136 | (R)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}serinamide | Drug Info | [68] | |||
| 137 | (R)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide | Drug Info | [68] | |||
| 138 | (R/R)BEFLOXATONE | Drug Info | [69] | |||
| 139 | (S)(+)-2-(4-fluorophenyl)-7-methoxychroman-4-one | Drug Info | [62] | |||
| 140 | (S)(+)-7-fluoro-2-(4-fluorophenyl)chroman-4-one | Drug Info | [62] | |||
| 141 | (S)(+)-7-fluoro-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 142 | (S)(+)-7-fluoro-2-phenylchroman-4-one | Drug Info | [62] | |||
| 143 | (S)(+)-7-methyl-2-p-tolylchroman-4-one | Drug Info | [62] | |||
| 144 | (S)(+)-7-methyl-2-phenylchroman-4-one | Drug Info | [62] | |||
| 145 | (S)-2-amino-1-(4-butylthiophenyl)-propane | Drug Info | [70] | |||
| 146 | (S)-2-amino-1-(4-propylthiophenyl)-propane | Drug Info | [70] | |||
| 147 | (S)-N2-[4-(benzyloxy)benzyl]alaninamide | Drug Info | [68] | |||
| 148 | (S)-N2-[4-(benzyloxy)benzyl]serinamide | Drug Info | [68] | |||
| 149 | (S)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide | Drug Info | [68] | |||
| 150 | (S)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}serinamide | Drug Info | [68] | |||
| 151 | (S)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}serinamide | Drug Info | [68] | |||
| 152 | (S)-N2-{4-[(4-chlorobenzyl)oxy]benzyl}alaninamide | Drug Info | [68] | |||
| 153 | (S)-N2-{4-[(4-chlorobenzyl)oxy]benzyl}serinamide | Drug Info | [68] | |||
| 154 | (S)-N2-{4-[(4-nitrobenzyl)oxy]benzyl}serinamide | Drug Info | [68] | |||
| 155 | 1,2,3,4-Tetrahydro-naphthalen-1-ylamine | Drug Info | [71] | |||
| 156 | 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | Drug Info | [72] | |||
| 157 | 1,4-diphenyl-(1E,3E)-1,3-butadiene | Drug Info | [53] | |||
| 158 | 1-(4-(benzyloxy)phenyl)propan-2-amine | Drug Info | [63] | |||
| 159 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Drug Info | [73] | |||
| 160 | 1H-Indole-2,3-dione | Drug Info | [53], [74] | |||
| 161 | 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole | Drug Info | [45] | |||
| 162 | 2-(2,4-dichlorophenyl)-4,5-dihydro-1H-imidazole | Drug Info | [75] | |||
| 163 | 2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole | Drug Info | [76] | |||
| 164 | 2-(2-cyclohexylidenehydrazinyl)-4-p-tolylthiazole | Drug Info | [76] | |||
| 165 | 2-(2-cyclohexylidenehydrazinyl)-4-phenylthiazole | Drug Info | [76] | |||
| 166 | 2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole | Drug Info | [76] | |||
| 167 | 2-(3-nitrophenyl)-4,5-dihydro-1H-imidazole | Drug Info | [75] | |||
| 168 | 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline | Drug Info | [75] | |||
| 169 | 2-(4-chlorophenyl)-4,5-dihydro-1H-imidazole | Drug Info | [75] | |||
| 170 | 2-(4-fluorophenyl)-7-methoxy-4H-chromen-4-one | Drug Info | [62] | |||
| 171 | 2-(4-methoxyphenyl)-4H-chromene-4-thione | Drug Info | [62] | |||
| 172 | 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole | Drug Info | [77] | |||
| 173 | 2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole | Drug Info | [75] | |||
| 174 | 2-BFi | Drug Info | [75] | |||
| 175 | 2-Bromo-N-(2-morpholinoethyl)nicotinamide | Drug Info | [78] | |||
| 176 | 2-Bromo-N-(3-morpholinopropyl)nicotinamide | Drug Info | [78] | |||
| 177 | 2-Chloro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [78] | |||
| 178 | 2-Chloro-N-(3-morpholinopropyl)nicotinamide | Drug Info | [78] | |||
| 179 | 2-Furan-2-yl-4,5-dihydro-1H-imidazole | Drug Info | [79] | |||
| 180 | 2-Hydrazino-3-methyl-4(3H)-quinazolinone | Drug Info | [80] | |||
| 181 | 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one | Drug Info | [81] | |||
| 182 | 2-oxo-N-m-tolyl-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 183 | 2-oxo-N-p-tolyl-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 184 | 2-oxo-N-phenyl-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 185 | 2-p-tolyl-4,5-dihydro-1H-imidazole | Drug Info | [75] | |||
| 186 | 2-p-tolyl-4H-chromen-4-one | Drug Info | [62] | |||
| 187 | 2-p-tolyl-4H-chromene-4-thione | Drug Info | [62] | |||
| 188 | 2-Phenethyl-4,5-dihydro-1H-imidazole | Drug Info | [79] | |||
| 189 | 2-Phenoxymethyl-4,5-dihydro-1H-imidazole | Drug Info | [79] | |||
| 190 | 2-phenyl-9H-indeno[2,1-d]pyrimidine | Drug Info | [81] | |||
| 191 | 2-Phenyl-cyclopropylamine hydrochloride | Drug Info | [83] | |||
| 192 | 2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide | Drug Info | [64] | |||
| 193 | 3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin | Drug Info | [84] | |||
| 194 | 3,4-Benzo-7-acetonyloxy-8-methoxycoumarin | Drug Info | [84] | |||
| 195 | 3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | Drug Info | [85] | |||
| 196 | 3-(2-Bromophenyl)-6-methylcoumarin | Drug Info | [86] | |||
| 197 | 3-(3-methoxyphenyl)-6-methyl-2H-chromen-2-one | Drug Info | [87] | |||
| 198 | 3-(4-hydroxyphenyl)-6-methyl-2H-chromen-2-one | Drug Info | [87] | |||
| 199 | 3-(4-methoxyphenyl)-6-methyl-2H-chromen-2-one | Drug Info | [87] | |||
| 200 | 3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one | Drug Info | [81] | |||
| 201 | 3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide | Drug Info | [85] | |||
| 202 | 3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one | Drug Info | [81] | |||
| 203 | 4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin | Drug Info | [84] | |||
| 204 | 4,9-Dihydro-3H-beta-carboline | Drug Info | [72] | |||
| 205 | 4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid | Drug Info | [82] | |||
| 206 | 4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one | Drug Info | [64] | |||
| 207 | 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN | Drug Info | [67] | |||
| 208 | 4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one | Drug Info | [84] | |||
| 209 | 4-oxo-4H-chromene-3-carboxylic acid | Drug Info | [89] | |||
| 210 | 4-phenyl-1,2,3,6-tetrahydropyridine | Drug Info | [73] | |||
| 211 | 5-Aminomethyl-3-pyrrol-1-yl-oxazolidin-2-one | Drug Info | [69] | |||
| 212 | 5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 213 | 5-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 214 | 5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one | Drug Info | [69] | |||
| 215 | 5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 216 | 5-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 217 | 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE | Drug Info | [90] | |||
| 218 | 6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one | Drug Info | [84] | |||
| 219 | 6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 220 | 6-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 221 | 6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [72] | |||
| 222 | 6-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [72] | |||
| 223 | 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin | Drug Info | [91] | |||
| 224 | 7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin | Drug Info | [84] | |||
| 225 | 7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin | Drug Info | [84] | |||
| 226 | 7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 227 | 7-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 228 | 7-fluoro-2-(4-fluorophenyl)-4H-chromene-4-thione | Drug Info | [62] | |||
| 229 | 7-fluoro-2-(4-methoxyphenyl)-4H-chromen-4-one | Drug Info | [62] | |||
| 230 | 7-fluoro-2-p-tolyl-4H-chromen-4-one | Drug Info | [62] | |||
| 231 | 7-fluoro-2-p-tolyl-4H-chromene-4-thione | Drug Info | [62] | |||
| 232 | 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [79] | |||
| 233 | 7-methoxy-2-p-tolyl-4H-chromen-4-one | Drug Info | [62] | |||
| 234 | 7-methoxy-2-p-tolyl-4H-chromene-4-thione | Drug Info | [62] | |||
| 235 | 7-Methoxy-9H-beta-carboline | Drug Info | [45] | |||
| 236 | 7-methyl-2-p-tolyl-4H-chromene-4-thione | Drug Info | [62] | |||
| 237 | 8-(3-Bromobenzyloxy)caffeine | Drug Info | [92] | |||
| 238 | 8-(3-Chlorobenzyloxy)caffeine | Drug Info | [92] | |||
| 239 | 8-(3-Fluorobenzyloxy)caffeine | Drug Info | [92] | |||
| 240 | 8-(3-Methoxybenzyloxy)caffeine | Drug Info | [92] | |||
| 241 | 8-(3-Methylbenzyloxy)caffeine | Drug Info | [92] | |||
| 242 | 8-Benzyloxycaffeine | Drug Info | [92] | |||
| 243 | 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 244 | 8-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 245 | 8-Bromo-6-methyl-3-(4'-methoxyphenyl)coumarin | Drug Info | [86] | |||
| 246 | 8-Bromo-6-methyl-3-phenylcoumarin | Drug Info | [86] | |||
| 247 | 8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 248 | 8-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [45] | |||
| 249 | 8-[(3-Trifluoromethyl)benzyloxy]caffeine | Drug Info | [92] | |||
| 250 | 9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [45] | |||
| 251 | Benzyl-methyl-[1-(1H-pyrrol-2-yl)-vinyl]-amine | Drug Info | [93] | |||
| 252 | Butyl-methyl-prop-2-ynyl-amine hydrochloride | Drug Info | [95] | |||
| 253 | C-(1H-Indol-3-yl)-methylamine | Drug Info | [45] | |||
| 254 | CGS-19281A | Drug Info | [72] | |||
| 255 | CHALCONE | Drug Info | [96] | |||
| 256 | Cis-2-(4-chlorophenyl)-2-fluorocyclopropanamine | Drug Info | [97] | |||
| 257 | Cis-2-(para-fluorophenyl)cyclopropylamine | Drug Info | [97] | |||
| 258 | Cis-2-Fluoro-2-(4-methoxyphenyl)cyclopropylamine | Drug Info | [97] | |||
| 259 | Cis-2-fluoro-2-phenylcyclopropanamine | Drug Info | [97] | |||
| 260 | Cis-2-phenylcyclopropylamine | Drug Info | [97] | |||
| 261 | CORDOIN | Drug Info | [96] | |||
| 262 | Deprenyl | Drug Info | [98] | |||
| 263 | Farnesol | Drug Info | [67] | |||
| 264 | Flavanone | Drug Info | [62] | |||
| 265 | Flavin-Adenine Dinucleotide | Drug Info | [99] | |||
| 266 | Heptyl-methyl-prop-2-ynyl-amine hydrochloride | Drug Info | [95] | |||
| 267 | HYDRAZINECARBOXAMIDE | Drug Info | [83] | |||
| 268 | IPRONIAZIDE | Drug Info | [78] | |||
| 269 | Isopropyl-methyl-prop-2-ynyl-amine hydrochloride | Drug Info | [95] | |||
| 270 | JD-0100 | Drug Info | [39] | |||
| 271 | L-136662 | Drug Info | [90] | |||
| 272 | Lauryl Dimethylamine-N-Oxide | Drug Info | [99] | |||
| 273 | Methyl piperate | Drug Info | [49] | |||
| 274 | Methyl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amine | Drug Info | [71] | |||
| 275 | Methyl-pentyl-prop-2-ynyl-amine oxalic acid | Drug Info | [95] | |||
| 276 | N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine | Drug Info | [101] | |||
| 277 | N-(1H-Indol-2-ylmethyl)-N-phenylamine | Drug Info | [101] | |||
| 278 | N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 279 | N-(2-aminoethyl)-p-chlorobenzamide | Drug Info | [67] | |||
| 280 | N-(2-Methyl-1H-indol-5-yl)benzamide | Drug Info | [85] | |||
| 281 | N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide | Drug Info | [85] | |||
| 282 | N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [102] | |||
| 283 | N-(2-Phenylethyl)-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 284 | N-(3-Phenylpropyl)-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 285 | N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 286 | N-(4-Phenylbutyl)-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 287 | N-(benzyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [102] | |||
| 288 | N-(propargyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [102] | |||
| 289 | N-Benzyl,N-methyl-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 290 | N-Benzyl-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 291 | N-benzyl-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 292 | N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine | Drug Info | [101] | |||
| 293 | N-cyclohexyl-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 294 | N-isobutyl-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 295 | N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [102] | |||
| 296 | N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [102] | |||
| 297 | N-Methyl,N-phenyl-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 298 | N-Methyl-N-phenyl-2-oxo-2H-chromene-3-carboxamide | Drug Info | [82] | |||
| 299 | N-Methyl-N-Propargyl-1(R)-Aminoindan | Drug Info | [67] | |||
| 300 | N-Phenyl-1H-indole-2-carboxamide | Drug Info | [101] | |||
| 301 | N-Propargyl-1(S)-Aminoindan | Drug Info | [67] | |||
| 302 | N2-[4-(benzyloxy)benzyl]glycinamide | Drug Info | [68] | |||
| 303 | N2-{4-[(3-chlorobenzyl)oxy]benzyl}glycinamide | Drug Info | [68] | |||
| 304 | N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide | Drug Info | [68] | |||
| 305 | N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide | Drug Info | [68] | |||
| 306 | N2-{4-[(4-nitrobenzyl)oxy]benzyl}glycinamide | Drug Info | [68] | |||
| 307 | NSC-50187 | Drug Info | [62] | |||
| 308 | NSC-93405 | Drug Info | [62] | |||
| 309 | NW-1772 | Drug Info | [39] | |||
| 310 | Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate | Drug Info | [75] | |||
| 311 | PNU-22394 | Drug Info | [45] | |||
| 312 | RS-1636 | Drug Info | [41] | |||
| 313 | SKL-PD | Drug Info | [39] | |||
| 314 | TOLOXATONE | Drug Info | [69] | |||
| 315 | TRACIZOLINE | Drug Info | [79] | |||
| 316 | Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine | Drug Info | [97] | |||
| 317 | Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine | Drug Info | [97] | |||
| 318 | Trans-2-fluoro-2-p-tolylcyclopropanamine | Drug Info | [97] | |||
| 319 | Trans-2-fluoro-2-phenylcyclopropylamin | Drug Info | [97] | |||
| 320 | TRYPTOLINE | Drug Info | [79] | |||
| 321 | VAR-10300 | Drug Info | [39] | |||
| 322 | [(1e)-4-Phenylbut-1-Enyl]Benzene | Drug Info | [67] | |||
| Antagonist | [+] 2 Antagonist drugs | + | ||||
| 1 | Beta-methoxyamphetamine | Drug Info | [94] | |||
| 2 | MMDA | Drug Info | [99] | |||
| Cell-based Target Expression Variations | Top | |||||
|---|---|---|---|---|---|---|
| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Zonisamide | Ligand Info | |||||
| Structure Description | Human monoamine oxidase B in complex with zonisamide | PDB:3PO7 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [103] |
| PDB Sequence |
NKCDVVVVGG
12 GISGMAAAKL22 LHDSGLNVVV32 LEARDRVGGR42 TYTLRNQKVK52 YVDLGGSYVG 62 PTQNRILRLA72 KELGLETYKV82 NEVERLIHHV92 KGKSYPFRGP102 FPPVWNPITY 112 LDHNNFWRTM122 DDMGREIPSD132 APWKAPLAEE142 WDNMTMKELL152 DKLCWTESAK 162 QLATLFVNLC172 VTAETHEVSA182 LWFLWYVKQC192 GGTTRIISTT202 NGGQERKFVG 212 GSGQVSERIM222 DLLGDRVKLE232 RPVIYIDQTR242 ENVLVETLNH252 EMYEAKYVIS 262 AIPPTLGMKI272 HFNPPLPMMR282 NQMITRVPLG292 SVIKCIVYYK302 EPFWRKKDYC 312 GTMIIDGEEA322 PVAYTLDDTK332 PEGNYAAIMG342 FILAHKARKL352 ARLTKEERLK 362 KLCELYAKVL372 GSLEALEPVH382 YEEKNWCEEQ392 YSGGCYTTYF402 PPGILTQYGR 412 VLRQPVDRIY422 FAGTETATHW432 SGYMEGAVEA442 GERAAREILH452 AMGKIPEDEI 462 WQSEPESVDV472 PAQPITTTFL482 ERHLPSVPGL492 LRLIGLTTI
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| Ligand Name: (R)-3-Prop-2-ynylamino-indan-5-ol | Ligand Info | |||||
| Structure Description | Crystal structure of MAOB in complex with 6-hydroxy-N-propargyl-1(R)-aminoindan | PDB:1S3E | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [104] |
| PDB Sequence |
NKCDVVVVGG
12 GISGMAAAKL22 LHDSGLNVVV32 LEARDRVGGR42 TYTLRNQKVK52 YVDLGGSYVG 62 PTQNRILRLA72 KELGLETYKV82 NEVERLIHHV92 KGKSYPFRGP102 FPPVWNPITY 112 LDHNNFWRTM122 DDMGREIPSD132 APWKAPLAEE142 WDNMTMKELL152 DKLCWTESAK 162 QLATLFVNLC172 VTAETHEVSA182 LWFLWYVKQC192 GGTTRIISTT202 NGGQERKFVG 212 GSGQVSERIM222 DLLGDRVKLE232 RPVIYIDQTR242 ENVLVETLNH252 EMYEAKYVIS 262 AIPPTLGMKI272 HFNPPLPMMR282 NQMITRVPLG292 SVIKCIVYYK302 EPFWRKKDYC 312 GTMIIDGEEA322 PVAYTLDDTK332 PEGNYAAIMG342 FILAHKARKL352 ARLTKEERLK 362 KLCELYAKVL372 GSLEALEPVH382 YEEKNWCEEQ392 YSGGCYTTYF402 PPGILTQYGR 412 VLRQPVDRIY422 FAGTETATHW432 SGYMEGAVEA442 GERAAREILH452 AMGKIPEDEI 462 WQSEPESVDV472 PAQPITTTFL482 ERHLPSVPGL492 LRLIGLTTI
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
|---|---|
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation
of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes
(Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors
of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information
(Front Pharmacol, 9, 1245, 2018;
Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
|
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There is no similarity protein (E value < 0.005) for this target
|
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
|
| KEGG Pathway | Pathway ID | Affiliated Target | Pathway Map |
|---|---|---|---|
| Glycine, serine and threonine metabolism | hsa00260 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Arginine and proline metabolism | hsa00330 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Histidine metabolism | hsa00340 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Tyrosine metabolism | hsa00350 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Phenylalanine metabolism | hsa00360 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Tryptophan metabolism | hsa00380 | Affiliated Target |
|
| Class: Metabolism => Amino acid metabolism | Pathway Hierarchy | ||
| Drug metabolism - cytochrome P450 | hsa00982 | Affiliated Target |
|
| Class: Metabolism => Xenobiotics biodegradation and metabolism | Pathway Hierarchy | ||
| Serotonergic synapse | hsa04726 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Dopaminergic synapse | hsa04728 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Click to Show/Hide the Information of Affiliated Human Pathways | |||
| Degree | 2 | Degree centrality | 2.15E-04 | Betweenness centrality | 0.00E+00 |
|---|---|---|---|---|---|
| Closeness centrality | 1.54E-01 | Radiality | 1.22E+01 | Clustering coefficient | 1.00E+00 |
| Neighborhood connectivity | 9.00E+00 | Topological coefficient | 6.43E-01 | Eccentricity | 12 |
| Download | Click to Download the Full PPI Network of This Target | ||||
| Chemical Structure based Activity Landscape of Target | Top |
|---|---|
| Drug Property Profile of Target | Top | |
|---|---|---|
| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Co-Targets | Top | |||||
|---|---|---|---|---|---|---|
| Co-Targets | ||||||
| Target Poor or Non Binders | Top | |||||
|---|---|---|---|---|---|---|
| Target Poor or Non Binders | ||||||
| Target Profiles in Patients | Top | |||||
|---|---|---|---|---|---|---|
| Target Expression Profile (TEP) | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| BioCyc | [+] 5 BioCyc Pathways | + | ||||
| 1 | Superpathway of tryptophan utilization | |||||
| 2 | Tryptophan degradation via tryptamine | |||||
| 3 | Dopamine degradation | |||||
| 4 | Putrescine degradation III | |||||
| 5 | Noradrenaline and adrenaline degradation | |||||
| KEGG Pathway | [+] 13 KEGG Pathways | + | ||||
| 1 | Glycine, serine and threonine metabolism | |||||
| 2 | Arginine and proline metabolism | |||||
| 3 | Histidine metabolism | |||||
| 4 | Tyrosine metabolism | |||||
| 5 | Phenylalanine metabolism | |||||
| 6 | Tryptophan metabolism | |||||
| 7 | Drug metabolism - cytochrome P450 | |||||
| 8 | Metabolic pathways | |||||
| 9 | Serotonergic synapse | |||||
| 10 | Dopaminergic synapse | |||||
| 11 | Cocaine addiction | |||||
| 12 | Amphetamine addiction | |||||
| 13 | Alcoholism | |||||
| Panther Pathway | [+] 3 Panther Pathways | + | ||||
| 1 | Adrenaline and noradrenaline biosynthesis | |||||
| 2 | 5-Hydroxytryptamine degredation | |||||
| 3 | Dopamine receptor mediated signaling pathway | |||||
| PID Pathway | [+] 1 PID Pathways | + | ||||
| 1 | Alpha-synuclein signaling | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | Tryptophan metabolism | |||||
| 2 | Dopamine metabolism | |||||
| 3 | Phase 1 - Functionalization of compounds | |||||
| Target-Related Models and Studies | Top | |||||
|---|---|---|---|---|---|---|
| Target Validation | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Tranylcypromine: new perspectives on an "old" drug. Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):268-73. | |||||
| REF 2 | Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105. | |||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7266). | |||||
| REF 5 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011909. | |||||
| REF 6 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6641). | |||||
| REF 7 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. | |||||
| REF 8 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018 | |||||
| REF 9 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||||
| REF 10 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6639). | |||||
| REF 11 | ClinicalTrials.gov (NCT00640159) Tolerability and Efficacy of Switch From Oral Selegiline to Orally Disintegrating Selegiline (Zelapar) in Patients With Parkinson's Disease. U.S. National Institutes of Health. | |||||
| REF 12 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. | |||||
| REF 13 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018557. | |||||
| REF 14 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 15 | Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. IDrugs. 2007 Sep;10(9):636-44. | |||||
| REF 16 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | |||||
| REF 17 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 18 | Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94. | |||||
| REF 19 | ClinicalTrials.gov (NCT03867253) A Multicentre,Randomised, Double-blind, Placebo-controlled, 3-arm, 24-week Parallel-group Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ORY-2001 in Patients With Mild-moderate Alzheimer's Disease. U.S.National Institutes of Health. | |||||
| REF 20 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026046) | |||||
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