Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0E4HB
|
|||
Former ID |
DNC011207
|
|||
Drug Name |
2-(2-cyclohexylidenehydrazinyl)-4-phenylthiazole
|
|||
Synonyms |
CHEMBL220495; 2-(2-cyclohexylidenehydrazinyl)-4-phenylthiazole; AC1P6Q43; SCHEMBL19017688; ZINC7350105; BDBM50326652; AKOS005139675; ST51067929; N-(cyclohexylideneamino)-4-phenyl-thiazol-2-amine; 1-cyclohexylidene-2-(4-phenylthiazol-2-yl)hydrazine; N-(cyclohexylideneamino)-4-phenyl-1,3-thiazol-2-amine
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C15H17N3S
|
|||
Canonical SMILES |
C1CCC(=NNC2=NC(=CS2)C3=CC=CC=C3)CC1
|
|||
InChI |
1S/C15H17N3S/c1-3-7-12(8-4-1)14-11-19-15(16-14)18-17-13-9-5-2-6-10-13/h1,3-4,7-8,11H,2,5-6,9-10H2,(H,16,18)
|
|||
InChIKey |
RQMWJSWLKXHIEZ-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Monoamine oxidase type B (MAO-B) | Target Info | Inhibitor | [1] |
BioCyc | Superpathway of tryptophan utilization | |||
Tryptophan degradation via tryptamine | ||||
Dopamine degradation | ||||
Putrescine degradation III | ||||
Noradrenaline and adrenaline degradation | ||||
KEGG Pathway | Glycine, serine and threonine metabolism | |||
Arginine and proline metabolism | ||||
Histidine metabolism | ||||
Tyrosine metabolism | ||||
Phenylalanine metabolism | ||||
Tryptophan metabolism | ||||
Drug metabolism - cytochrome P450 | ||||
Metabolic pathways | ||||
Serotonergic synapse | ||||
Dopaminergic synapse | ||||
Cocaine addiction | ||||
Amphetamine addiction | ||||
Alcoholism | ||||
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
5-Hydroxytryptamine degredation | ||||
Dopamine receptor mediated signaling pathway | ||||
Pathway Interaction Database | Alpha-synuclein signaling | |||
WikiPathways | Tryptophan metabolism | |||
Dopamine metabolism | ||||
Phase 1 - Functionalization of compounds |
References | Top | |||
---|---|---|---|---|
REF 1 | Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.