| Drug General Information |
| Drug ID |
D07LUR
|
| Former ID |
DNC002440
|
| Drug Name |
Alpha-D-Mannose
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H12O6
|
| Canonical SMILES |
C(C1C(C(C(C(O1)O)O)O)O)O
|
| InChI |
1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
|
| InChIKey |
WQZGKKKJIJFFOK-PQMKYFCFSA-N
|
| CAS Number |
CAS 3458-28-4
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4188, 584309, 584577, 585323, 585890, 818886, 819860, 820291, 820631, 820632, 820633, 820923, 821116, 821332, 821413, 821424, 821447, 821561, 821794, 821798, 821933, 821940, 821956, 821963, 822552, 822575, 822586, 822746, 822775, 822831, 823017, 823023, 823058, 823092, 824133, 824135, 824229, 825243, 825244, 825245, 825293, 825294, 825295, 825297, 825440, 825444, 825448, 825898, 826257, 827093
|
| Target and Pathway |
| Target(s) |
ADAM 33 |
Target Info |
Inhibitor |
[1]
|
|---|
| Liver carboxylesterase |
Target Info |
Inhibitor |
[1]
|
| Lactotransferrin |
Target Info |
Inhibitor |
[1]
|
| Reticulon 4 receptor |
Target Info |
Inhibitor |
[1]
|
| Neuraminidase |
Target Info |
Inhibitor |
[1]
|
| Cytotoxic T-lymphocyte protein 4 |
Target Info |
Inhibitor |
[1]
|
| Antithrombin-III |
Target Info |
Inhibitor |
[1]
|
| Glycoprotein hormones alpha chain |
Target Info |
Inhibitor |
[1]
|
| Phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
| Rhodopsin |
Target Info |
Inhibitor |
[1]
|
| Insulin-like growth factor I receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-galactosidase A |
Target Info |
Inhibitor |
[1]
|
| Prostaglandin G/H synthase 1 |
Target Info |
Inhibitor |
[1]
|
| Interleukin-6 receptor |
Target Info |
Inhibitor |
[1]
|
| Low-density lipoprotein receptor |
Target Info |
Inhibitor |
[1]
|
| Heparin cofactor II |
Target Info |
Inhibitor |
[1]
|
| Hemagglutinin |
Target Info |
Inhibitor |
[1]
|
| Beta-2-glycoprotein 1 |
Target Info |
Inhibitor |
[1]
|
| Cathepsin D |
Target Info |
Inhibitor |
[1]
|
| Dipeptidyl peptidase IV |
Target Info |
Inhibitor |
[1]
|
| Lactase-phlorizin hydrolase |
Target Info |
Inhibitor |
[1]
|
| T-cell surface antigen CD2 |
Target Info |
Inhibitor |
[1]
|
| Cholinesterase |
Target Info |
Inhibitor |
[1]
|
| Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
| Deoxyribonuclease I |
Target Info |
Inhibitor |
[1]
|
| High affinity immunoglobulin epsilon receptor |
Target Info |
Inhibitor |
[1]
|
| Membrane-associated lectin type-C |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
PhospholipasesPWY66-374:C20 prostanoid biosynthesisPWY-6241:Thyroid hormone biosynthesisPWY-4983:Citrulline-nitric oxide cycle
|
|
KEGG Pathway
|
Drug metabolism - other enzymes
|
|
Metabolic pathwaysstm00511:Other glycan degradationhsa04514:Cell adhesion molecules (CAMs)
|
|
T cell receptor signaling pathway
|
|
Autoimmune thyroid disease
|
|
Rheumatoid arthritishsa04610:Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
|
|
GnRH signaling pathway
|
|
Ovarian steroidogenesis
|
|
Prolactin signaling pathway
|
|
Thyroid hormone synthesis
|
|
Autoimmune thyroid diseasehsa00564:Glycerophospholipid metabolism
|
|
Ether lipid metabolism
|
|
Arachidonic acid metabolism
|
|
Linoleic acid metabolism
|
|
alpha-Linolenic acid metabolism
|
|
Metabolic pathways
|
|
Ras signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Pancreatic secretion
|
|
Fat digestion and absorptionhsa04744:Phototransductionhsa04014:Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
Oocyte meiosis
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Focal adhesion
|
|
Adherens junction
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Long-term depression
|
|
Progesterone-mediated oocyte maturation
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Proteoglycans in cancer
|
|
Glioma
|
|
Prostate cancer
|
|
Melanomahsa00052:Galactose metabolism
|
|
Glycerolipid metabolism
|
|
Sphingolipid metabolism
|
|
Glycosphingolipid biosynthesis - globo series
|
|
Lysosomehsa00590:Arachidonic acid metabolism
|
|
Platelet activation
|
|
Serotonergic synapsehsa04060:Cytokine-cytokine receptor interaction
|
|
Jak-STAT signaling pathway
|
|
Hematopoietic cell lineage
|
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Non-alcoholic fatty liver disease (NAFLD)hsa04144:Endocytosis
|
|
Bile secretion
|
|
Toxoplasmosis
|
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Hepatitis Chsa04610:Complement and coagulation cascadeshsa04071:Sphingolipid signaling pathway
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Lysosome
|
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Tuberculosishsa04974:Protein digestion and absorptionhsa00052:Galactose metabolism
|
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Carbohydrate digestion and absorptionhsa04514:Cell adhesion molecules (CAMs)
|
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Hematopoietic cell lineagehsa00330:Arginine and proline metabolism
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Calcium signaling pathway
|
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Phagosome
|
|
Circadian entrainment
|
|
Salivary secretion
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)hsa04071:Sphingolipid signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Asthmahsa04145:Phagosome
|
|
Tuberculosis
|
|
Measles
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
|
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
|
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PANTHER Pathway
|
Blood coagulationP04394:Thyrotropin-releasing hormone receptor signaling pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
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Insulin/IGF pathway-protein kinase B signaling cascadeP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
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Nicotinic acetylcholine receptor signaling pathwayP06959:CCKR signaling map ST
|
|
Pathway Interaction Database
|
E2F transcription factor networkp75ntrpathway:p75(NTR)-mediated signalingnfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytesglypican_1pathway:Glypican 1 networkreg_gr_pathway:Glucocorticoid receptor regulatory networkfcer1pathway:Fc-epsilon receptor I signaling in mast cellsrhodopsin_pathway:Visual signal transduction: Rodser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
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SHP2 signaling
|
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IGF1 pathway
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
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Integrins in angiogenesis
|
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Stabilization and expansion of the E-cadherin adherens junctionlkb1_pathway:LKB1 signaling events
|
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Ceramide signaling pathway
|
|
Direct p53 effectors
|
|
Validated nuclear estrogen receptor alpha network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
|
|
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/ChoriogonadotropinPW000148:Sphingolipid Metabolism
|
|
Galactose MetabolismPW000044:Arachidonic Acid MetabolismPW000153:Lactose Degradation
|
|
Galactose MetabolismPW000010:Arginine and Proline MetabolismPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Reactome
|
ROS production in response to bacteria
|
|
Amyloid formationR-HSA-193634:Axonal growth inhibition (RHOA activation)R-HSA-389513:CTLA4 inhibitory signalingR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
|
|
Common Pathway of Fibrin Clot FormationR-HSA-193048:Androgen biosynthesis
|
|
Thyroxine biosynthesis
|
|
Hormone ligand-binding receptors
|
|
G alpha (s) signalling eventsR-HSA-1482788:Acyl chain remodelling of PC
|
|
Acyl chain remodelling of PE
|
|
Acyl chain remodelling of PIR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
|
|
Inactivation, recovery and regulation of the phototransduction cascade
|
|
G alpha (i) signalling eventsR-HSA-2428928:IRS-related events triggered by IGF1R
|
|
SHC-related events triggered by IGF1RR-HSA-1660662:Glycosphingolipid metabolismR-HSA-110056:MAPK3 (ERK1) activation
|
|
MAPK1 (ERK2) activationR-HSA-171052:LDL-mediated lipid transport
|
|
Chylomicron-mediated lipid transport
|
|
Retinoid metabolism and transportR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
|
|
Common Pathway of Fibrin Clot FormationR-HSA-1442490:Collagen degradation
|
|
Metabolism of Angiotensinogen to Angiotensins
|
|
MHC class II antigen presentationR-HSA-202733:Cell surface interactions at the vascular wallR-HSA-1222556:ROS production in response to bacteria
|
|
Nitric oxide stimulates guanylate cyclaseR-HSA-2454202:Fc epsilon receptor (FCERI) signaling
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
FCERI mediated MAPK activation
|
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FCERI mediated Ca+2 mobilization
|
|
FCERI mediated NF-kB activationR-HSA-5621575:CD209 (DC-SIGN) signaling
|
|
WikiPathways
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Heroin metabolism
|
|
Irinotecan Pathway
|
|
Fluoropyrimidine Activity
|
|
Phase I biotransformations, non P450WP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP2431:Spinal Cord InjuryWP2877:Vitamin D Receptor Pathway
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Allograft Rejection
|
|
Costimulation by the CD28 familyWP558:Complement and Coagulation Cascades
|
|
Formation of Fibrin Clot (Clotting Cascade)WP2749:Metabolism of steroid hormones and vitamin D
|
|
Metabolism of amino acids and derivatives
|
|
Peptide hormone biosynthesis
|
|
FSH signaling pathway
|
|
TSH signaling pathway
|
|
Thyroxine (Thyroid Hormone) Production
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP2740:Glycerophospholipid biosynthesisWP455:GPCRs, Class A Rhodopsin-like
|
|
Visual phototransduction
|
|
Regulation of Microtubule Cytoskeleton
|
|
Integrated Breast Cancer Pathway
|
|
Integrin-mediated Cell AdhesionWP615:Senescence and Autophagy in Cancer
|
|
Insulin Signaling
|
|
Endochondral Ossification
|
|
Focal Adhesion
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
Apoptosis
|
|
Signaling Pathways in Glioblastoma
|
|
MicroRNAs in cardiomyocyte hypertrophyWP2788:Sphingolipid metabolismWP98:Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Phase 1 - Functionalization of compounds
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP706:SIDS Susceptibility Pathways
|
|
Senescence and Autophagy in Cancer
|
|
IL-6 signaling pathway
|
|
Differentiation Pathway
|
|
Interleukin-6 signalingWP710:DNA Damage Response (only ATM dependent)
|
|
Statin Pathway
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
Lipid digestion, mobilization, and transport
|
|
Oncostatin M Signaling Pathway
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
SREBP signalling
|
|
Folate Metabolism
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient NetworkWP558:Complement and Coagulation CascadesWP1848:Metabolism of carbohydratesWP1794:Cell surface interactions at the vascular wallWP229:Irinotecan PathwayWP727:Monoamine Transport
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
|
Spinal Cord Injury
|
|
Alzheimers Disease
|
|
Effects of Nitric Oxide
|
|
Serotonin Transporter ActivityWP2865:IL1 and megakaryotyces in obesity
|
|
Fc epsilon receptor (FCERI) signaling
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
