Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T59082
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| Former ID |
TTDR00854
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| Target Name |
Membrane-associated lectin type-C
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| Gene Name |
CD209
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| Synonyms |
CD 209; DC-SIGN; DC-SIGN1; DC-specific ICAM-3 grabbing nonintegrin; Dendritic cell-specific ICAM-3-grabbing nonintegrin 1; MDC-SIGN1A type I isoform; Probable mannose-binding C-type lectin DC-SIGN; Surface C-type lectin DC-SIGN; CD209
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| Target Type |
Research
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| Function |
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
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| BioChemical Class |
Transmembrane protein
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| UniProt ID | |||||
| Sequence |
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQV
SKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKL QEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAV GELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQ ELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQ NFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFS GNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA |
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| Structure |
1K9I; 1SL4; 1SL5; 2B6B; 2IT5; 2IT6; 2XR5; 2XR6
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| Inhibitor | Alpha-D-Mannose | Drug Info | [1] | ||
| Fucose | Drug Info | [1] | |||
| Pathways | |||||
| KEGG Pathway | Phagosome | ||||
| Tuberculosis | |||||
| Measles | |||||
| Reactome | CD209 (DC-SIGN) signaling | ||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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