Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T67258
|
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| Former ID |
TTDS00378
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| Target Name |
Heparin cofactor II
|
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| Gene Name |
SERPIND1
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| Synonyms |
HC-II; HLS2; Protease inhibitor leuserpin 2; SERPIND1
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| Target Type |
Research
|
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| Function |
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
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| BioChemical Class |
Serpin family
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| UniProt ID | |||||
| Sequence |
MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFH
KENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGK SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV REYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWV NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVP HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK NGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY EHRTSCLLFMGRVANPSRS |
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| Inhibitor | Alpha-D-Mannose | Drug Info | [1] | ||
| Pathways | |||||
| KEGG Pathway | Complement and coagulation cascades | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
| Common Pathway of Fibrin Clot Formation | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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