Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T86885
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| Former ID |
TTDC00264
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| Target Name |
Beta-2-glycoprotein 1
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| Gene Name |
APOH
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| Synonyms |
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apo-H; Apolipoprotein H; B2GPI; Beta(2)GPI; Beta-2-glycoprotein I; APOH
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| Target Type |
Discontinued
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| Disease | Hughes syndrome [ICD9: 289.81; ICD10: D68.8] | ||||
| Function |
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
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| Target Validation |
T86885
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| UniProt ID | |||||
| Sequence |
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC |
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| Structure |
1C1Z; 1G4F; 1G4G; 1QUB; 2KRI; 3OP8; 4JHS
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| Drugs and Mode of Action | |||||
| Drug(s) | LJP-1082 | Drug Info | Discontinued in Phase 1 | Hughes syndrome | [1] |
| Inhibitor | Alpha-D-Mannose | Drug Info | [2] | ||
| LJP-1082 | Drug Info | [3] | |||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014345) | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 3 | Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65. | ||||
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