Target Information

Target General Infomation
Target ID
T86885
Former ID
TTDC00264
Target Name
Beta-2-glycoprotein 1
Gene Name
APOH
Synonyms
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apo-H; Apolipoprotein H; B2GPI; Beta(2)GPI; Beta-2-glycoprotein I; APOH
Target Type
Discontinued
Disease Hughes syndrome [ICD9: 289.81; ICD10: D68.8]
Function
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Target Validation
T86885
UniProt ID
P02749
Sequence
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD
SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM
FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL
DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC
KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC
Structure
1C1Z; 1G4F; 1G4G; 1QUB; 2KRI; 3OP8; 4JHS
Drugs and Mode of Action
Drug(s) LJP-1082 Drug Info Discontinued in Phase 1 Hughes syndrome [547236]
Inhibitor Alpha-D-Mannose Drug Info [551393]
LJP-1082 Drug Info [536055]
References
Ref 547236Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014345)
Ref 536055Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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