Target General Infomation
Target ID
T94692
Former ID
TTDR00225
Target Name
Low-density lipoprotein receptor
Gene Name
LDLR
Synonyms
LDL receptor; LDLR
Target Type
Successful
Disease Non-small cell lung cancer [ICD10: C33-C34]
Function
Binds ldl, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
BioChemical Class
LDLR family
UniProt ID
Sequence
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
NQDGYSYPSRQMVSLEDDVA
Structure
1AJJ; 1D2J; 1F5Y; 1F8Z; 1HJ7; 1HZ8; 1I0U; 1IJQ; 1LDL; 1LDR; 1LRX; 1N7D; 1XFE; 2FCW; 2KRI; 2LGP; 2M7P; 2MG9; 2W2M; 2W2N; 2W2O; 2W2P; 2W2Q; 3BPS; 3GCW; 3GCX; 3M0C; 3P5B; 3P5C; 3SO6; 4NE9
Drugs and Mode of Action
Drug(s) Porfimer Sodium Drug Info Approved Non-small cell lung cancer [551871]
Inhibitor Alpha-D-Mannose Drug Info [551393]
Modulator Porfimer Sodium Drug Info [556264]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Endocytosis
Ovarian steroidogenesis
Bile secretion
Toxoplasmosis
Hepatitis C
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
Reactome LDL-mediated lipid transport
Chylomicron-mediated lipid transport
Retinoid metabolism and transport
WikiPathways DNA Damage Response (only ATM dependent)
Statin Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Visual phototransduction
Lipid digestion, mobilization, and transport
Oncostatin M Signaling Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.