Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T98933 Target Info
Target Name Thyroid hormone receptor beta (THRB)
Synonyms c-erbA-beta; c-erbA-2; THR1; Nuclear receptor subfamily 1 group A member 2; NR1A2; ERBA2
Target Type Successful Target
Gene Name THRB
Biochemical Class Nuclear hormone receptor
UniProt ID
P10828
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-155-5p miRNA Info
miRNA Mature AC
MIMAT0000646
Sequence uuaaugcuaaucgugauagggguu
miRNA Species Homo sapiens
Regulation Mechanism miR-155 regulated THRB. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; RT-PCR [1]
Representative Target(s) Regulated by This miRNA Acetyl-CoA transporter (SLC33A1) Target Info
ACATN_HUMAN
Angiotensin II receptor type-1 (AGTR1) Target Info
AGTR1_HUMAN
miRNA Mature ID hsa-miR-200a-3p miRNA Info
miRNA Mature AC
MIMAT0000682
Sequence uaacacugucugguaacgaugu
miRNA Species Homo sapiens
Regulation Mechanism miR200-a represses the expression of THRB binds at the 3'UTR of THRB. [2]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
miRNA Mature ID hsa-miR-204-5p miRNA Info
miRNA Mature AC
MIMAT0000265
Sequence uucccuuugucauccuaugccu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Alkaline phosphatase tissue-nonspecific (ALPL) Target Info
PPBT_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-27a-3p miRNA Info
miRNA Mature AC
MIMAT0000084
Sequence uucacaguggcuaaguuccgc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Northern Blot; Western Blot [4]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-425-5p miRNA Info
miRNA Mature AC
MIMAT0003393
Sequence aaugacacgaucacucccguuga
miRNA Species Homo sapiens
Regulation Mechanism miR-425 regulated THRB. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; RT-PCR [1]
Representative Target(s) Regulated by This miRNA Fibroblast growth factor receptor 3 (FGFR3) Target Info
FGFR3_HUMAN
G1/S-specific cyclin-D1 (CCND1) Target Info
CCND1_HUMAN
miRNA Mature ID hsa-miR-452-5p miRNA Info
miRNA Mature AC
MIMAT0001635
Sequence aacuguuugcagaggaaacuga
miRNA Species Homo sapiens
Regulation Mechanism miR-452 directly targets 3'UTR of THRB transcript. [5]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [5]
Representative Target(s) Regulated by This miRNA CDK inhibitor 1B p27Kip1 (CDKN1B) Target Info
CDN1B_HUMAN
Dihydropyrimidinase related protein 2 (DPYSL2) Target Info
DPYL2_HUMAN
References  Top
REF 1 Epigenetic regulation of thyroid hormone receptor beta in renal cancer. PLoS One. 2014 May 21;9(5):e97624.
REF 2 MicroRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB. Br J Haematol. 2017 Jan;176(1):50-64.
REF 3 Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma. Biochim Biophys Acta. 2010 Nov;1802(11):995-1005.
REF 4 MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. Mol Cell Biol. 2011 Feb;31(4):744-55.
REF 5 Regulatory feedback loop between T3 and microRNAs in renal cancer. Mol Cell Endocrinol. 2014 Mar 25;384(1-2):61-70.

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