Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T53389 Target Info
Target Name TGF-beta receptor type I (TGFBR1)
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TbetaRI; TbetaR-I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; Serine/threonine-protein kinase receptor R4; SKR4; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD; ALK5; ALK-5
Target Type Clinical trial Target
Gene Name TGFBR1
Biochemical Class Kinase
UniProt ID
P36897
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-142-3p miRNA Info
miRNA Mature AC
MIMAT0000434
Sequence uguaguguuuccuacuuuaugga
miRNA Species Homo sapiens
Evidence Score (E-score) 3 +
1 Luciferase Reporter Assay; qRT-PCR; Western Blot [1]
2 Microarray [2]
3 Western Blot [3]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter G2 (ABCG2) Target Info
ABCG2_HUMAN
High mobility group protein B1 (HMGB1) Target Info
HMGB1_HUMAN
miRNA Mature ID hsa-let-7b-5p miRNA Info
miRNA Mature AC
MIMAT0000063
Sequence ugagguaguagguugugugguu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 GFP Reporter Assay; Western Blot; ELISA [4]
2 Luciferase Reporter Assay; RT-PCR [5]
Representative Target(s) Regulated by This miRNA Activin receptor-like kinase 2 (ALK-2) Target Info
ACVR1_HUMAN
CDK inhibitor 1B p27Kip1 (CDKN1B) Target Info
CDN1B_HUMAN
miRNA Mature ID hsa-let-7g-5p miRNA Info
miRNA Mature AC
MIMAT0000414
Sequence ugagguaguaguuuguacaguu
miRNA Species Homo sapiens
Regulation Mechanism Let-7g mimic induced a stepwise decrease of luciferase activity in plasmids carrying the wild-type 3'UTR sequence of TGFBR1 or SMAD2 but had no effect on plasmids carrying the mutant sequences. [7]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [6]
2 Luciferase Reporter Assay; Western Blot [7]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-xL (BCL-xL) Target Info
B2CL1_HUMAN
Caspase-3 (CASP3) Target Info
CASP3_HUMAN
miRNA Mature ID hsa-miR-140-5p miRNA Info
miRNA Mature AC
MIMAT0000431
Sequence cagugguuuuacccuaugguag
miRNA Species Homo sapiens
Regulation Mechanism miR-140-5p binds to the 3-UTR of TGFBR1. [8]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [8]
2 Luciferase Reporter Assay [9]
Representative Target(s) Regulated by This miRNA Adenosine deaminase (ADA) Target Info
ADA_HUMAN
Aspartyl aminopeptidase (DNPEP) Target Info
DNPEP_HUMAN
miRNA Mature ID hsa-miR-490-3p miRNA Info
miRNA Mature AC
MIMAT0002806
Sequence caaccuggaggacuccaugcug
miRNA Species Homo sapiens
Regulation Mechanism miR-490-3p inhibits CRC cell migration and invasion abilities in part by targeting to TGFBR1. [10]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [10]
2 Luciferase Reporter Assay; Western Blot [11]
Representative Target(s) Regulated by This miRNA G1/S-specific cyclin-D1 (CCND1) Target Info
CCND1_HUMAN
High mobility group protein HMGI-C (HMGA2) Target Info
HMGA2_HUMAN
miRNA Mature ID hsa-let-7c-5p miRNA Info
miRNA Mature AC
MIMAT0000064
Sequence ugagguaguagguuguaugguu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of let-7c-5p by mature miRNA precursor transfection resulted in the decreased protein level of target TGFBR1. [12]
Evidence Score (E-score) 1 +
1 qRT-PCR; Luciferase Reporter Assay; Western Blot [12]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-xL (BCL-xL) Target Info
B2CL1_HUMAN
Caspase-3 (CASP3) Target Info
CASP3_HUMAN
miRNA Mature ID hsa-miR-135b-5p miRNA Info
miRNA Mature AC
MIMAT0000758
Sequence uauggcuuuucauuccuauguga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [13]
Representative Target(s) Regulated by This miRNA Activin receptor type IB (ACVR1B) Target Info
ACV1B_HUMAN
Bone morphogenetic protein receptor (BMPR2) Target Info
BMPR2_HUMAN
miRNA Mature ID hsa-miR-181c-5p miRNA Info
miRNA Mature AC
MIMAT0000258
Sequence aacauucaaccugucggugagu
miRNA Species Homo sapiens
Regulation Mechanism TGFBR1, mRNA and protein expression in 26 glioblastoma tissues were negatively correlated with expression of miR-181c. [14]
Evidence Score (E-score) 1 +
1 Immunohistochemistry; Luciferase Reporter Assay; Western Blot [14]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Bone morphogenetic protein receptor (BMPR2) Target Info
BMPR2_HUMAN
miRNA Mature ID hsa-miR-204-5p miRNA Info
miRNA Mature AC
MIMAT0000265
Sequence uucccuuugucauccuaugccu
miRNA Species Homo sapiens
Regulation Mechanism TGFBR1 is a direct target of miR-204. [15]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [15]
Representative Target(s) Regulated by This miRNA Alkaline phosphatase tissue-nonspecific (ALPL) Target Info
PPBT_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-20a-5p miRNA Info
miRNA Mature AC
MIMAT0000075
Sequence uaaagugcuuauagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Immunoblot; Immunofluorescence; Luciferase Reporter Assay [16]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-27b-3p miRNA Info
miRNA Mature AC
MIMAT0000419
Sequence uucacaguggcuaaguucugc
miRNA Species Homo sapiens
Regulation Mechanism TGFBE1 was the target of miR-27b and miR-27b inhibited fibroblast activation. [17]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [17]
Representative Target(s) Regulated by This miRNA Adenosine A2b receptor (ADORA2B) Target Info
AA2BR_HUMAN
Albendazole monooxygenase (CYP3A4) Target Info
CP3A4_HUMAN
miRNA Mature ID hsa-miR-376c-3p miRNA Info
miRNA Mature AC
MIMAT0000720
Sequence aacauagaggaaauuccacgu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [18]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Insulin-like growth factor I receptor (IGF1R) Target Info
IGF1R_HUMAN
miRNA Mature ID hsa-miR-202-5p miRNA Info
miRNA Mature AC
MIMAT0002810
Sequence uuccuaugcauauacuucuuug
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [19]
Representative Target(s) Regulated by This miRNA B-cell-activating factor (TNFSF13B) Target Info
TN13B_HUMAN
TGF-beta receptor type I (TGFBR1) Target Info
TGFR1_HUMAN
References  Top
REF 1 MiR-142-3p represses TGF--induced growth inhibition through repression of TGFR1 in non-small cell lung cancer. FASEB J. 2014 Jun;28(6):2696-704.
REF 2 MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007 Jul 6;27(1):91-105.
REF 3 Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes. Oncotarget. 2017 Feb 28;8(9):15252-15266.
REF 4 Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension. PLoS One. 2014 Jun 30;9(6):e101055.
REF 5 Let-7b promotes alpaca hair growth via transcriptional repression of TGFbetaR I. Gene. 2016 Feb 10;577(1):32-6.
REF 6 The let-7g microRNA promotes follicular granulosa cell apoptosis by targeting transforming growth factor-beta type 1 receptor. Mol Cell Endocrinol. 2015 Jul 5;409:103-12.
REF 7 Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and SIRT-1 signaling. J Am Coll Cardiol. 2014 Apr 29;63(16):1685-94.
REF 8 MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology. 2013 Jul;58(1):205-17.
REF 9 miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor. BMC Cancer. 2019 Apr 29;19(1):405.
REF 10 MicroRNA-490-3p inhibits colorectal cancer metastasis by targeting TGFR1. BMC Cancer. 2015 Dec 29;15:1023.
REF 11 Polycomb complex mediated epigenetic reprogramming alters TGF-beta signaling via a novel EZH2/miR-490/TGIF2 axis thereby inducing migration and EMT po... Int J Cancer. 2019 Sep 1;145(5):1254-1269.
REF 12 Comprehensive gene and microRNA expression profiling reveals a role for microRNAs in human liver development. PLoS One. 2009 Oct 20;4(10):e7511.
REF 13 MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-/BMP signaling. EMBO J. 2014 Jun 2;33(11):1271-83.
REF 14 MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF- pathway. Biochem Biophys Res Commun. 2016 Jan 22;469(4):1041-8.
REF 15 MicroRNA-204/211 alters epithelial physiology. FASEB J. 2010 May;24(5):1552-71.
REF 16 FGF2 inhibits endothelial-mesenchymal transition through microRNA-20a-mediated repression of canonical TGF- signaling. J Cell Sci. 2016 Feb 1;129(3):569-79.
REF 17 miR-27b inhibits fibroblast activation via targeting TGF signaling pathway. BMC Cell Biol. 2017 Jan 17;18(1):9.
REF 18 MicroRNA-376c impairs transforming growth factor- and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 2013 Apr;61(4):864-72.
REF 19 miR-202 Diminishes TGF Receptors and Attenuates TGF1-Induced EMT in Pancreatic Cancer. Mol Cancer Res. 2017 Aug;15(8):1029-1039.

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