miRNA General Information
miRNA Mature ID hsa-miR-135b-5p
miRNA Stemloop AC MI0000810
miRNA Stemloop ID hsa-mir-135b
Sequence uauggcuuuucauuccuauguga
TTD Target(s) Regulated by This miRNA Extracellular calcium-sensing receptor (CASR) Successful Target Target Info [1]
TGF-beta receptor type I (TGFBR1) Clinical trial Target Target Info [2]
Kruppel like factor 4 (KLF4) Clinical trial Target Target Info [3]
Bone morphogenetic protein receptor (BMPR2) Literature-reported Target Target Info [2]
Activin receptor type IB (ACVR1B) Patented-recorded Target Target Info [2]
Forkhead box protein O1A (FOXO1) Literature-reported Target Target Info [4]
Signal transducer and activator of transcription 6 (STAT6) Literature-reported Target Target Info [5]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [6]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Adenomatous polyposis coli protein Regulated Protein [8]
Bone sialoprotein 2 Regulated Protein [6]
Disintegrin and metalloproteinase domain-containing protein 12 Regulated Protein [10]
E3 ubiquitin-protein ligase Midline-1 Regulated Protein [11]
Ecotropic viral integration site 5 protein homolog Regulated Protein [7]
Leucine zipper putative tumor suppressor 1 Regulated Protein [13]
Mitochondrial carrier homolog 2 Regulated Protein [11]
Mothers against decapentaplegic homolog 5 Regulated Protein [14]
Myocyte-specific enhancer factor 2C Regulated Protein [15]
Osteocalcin Regulated Protein [6]
Protein phosphatase 1E Regulated Protein [16]
Protein phosphatase 1E Regulated Protein [17]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Regulated Protein [18]
Thrombospondin-2 Regulated Protein [19]
Transcription factor MafB Regulated Protein [3]
Transcription factor Sp7 Regulated Protein [6]
References
REF 1 MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer Lett. 2013 May 1;331(2):230-8.
REF 2 MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-/BMP signaling. EMBO J. 2014 Jun 2;33(11):1271-83.
REF 3 Expression profiling of cytogenetically normal acute myeloid leukemia identifies microRNAs that target genes involved in monocytic differentiation. Am J Hematol. 2011 Jan;86(1):2-11.
REF 4 Down-regulation of microRNA-135b inhibited growth of cervical cancer cells by targeting FOXO1. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10294-304.
REF 5 miR-135b inhibits tumour metastasis in prostate cancer by targeting STAT6. Oncol Lett. 2016 Jan;11(1):543-550.
REF 6 MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev. 2010 Jun;19(6):877-85.
REF 7 MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget. 2015 Feb 10;6(4):2421-33.
REF 8 Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.Cancer Res. 2008 Jul 15;68(14):5795-802.
REF 9 MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev. 2010 Jun;19(6):877-85.
REF 10 miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal.Oncotarget. 2015 Nov 10;6(35):37241-56.
REF 11 miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2.Am J Pathol. 2013 Jun;182(6):2058-70.
REF 12 MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget. 2015 Feb 10;6(4):2421-33.
REF 13 MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.Nat Commun. 2013;4:1877.
REF 14 Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients.PLoS One. 2013 Nov 6;8(11):e79752.
REF 15 MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C.Sci Rep. 2015 Jul 17;5:12276.
REF 16 miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone.Oncotarget. 2016 Oct 25;7(43):70613-70622.
REF 17 AMPK phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.Oncotarget. 2017 May 9;8(19):31288-31296.
REF 18 Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes.Leukemia. 2013 Oct;27(10):2107-11.
REF 19 miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma.Oncogene. 2016 Dec 1;35(48):6177-6188.
REF 20 Expression profiling of cytogenetically normal acute myeloid leukemia identifies microRNAs that target genes involved in monocytic differentiation. Am J Hematol. 2011 Jan;86(1):2-11.

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