miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-27b-3p | ||||
miRNA Stemloop AC | MI0000440 | ||||
miRNA Stemloop ID | hsa-mir-27b | ||||
Sequence | uucacaguggcuaaguucugc | ||||
TTD Target(s) Regulated by This miRNA | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [1] | |
Proto-oncogene c-Ret (RET) | Successful Target | Target Info | [2] | ||
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Target Info | [3] | ||
Proto-oncogene c-Met (MET) | Successful Target | Target Info | [1] | ||
Vitamin D3 receptor (VDR) | Successful Target | Target Info | [4] | ||
ATP-binding cassette transporter A1 (ABCA1) | Successful Target | Target Info | [5] | ||
Adenosine A2b receptor (ADORA2B) | Successful Target | Target Info | [6] | ||
Endothelin A receptor (EDNRA) | Successful Target | Target Info | [7] | ||
Low-density lipoprotein receptor (LDL-R) | Successful Target | Target Info | [8] | ||
Dihydrothymine dehydrogenase (DPYD) | Successful Target | Target Info | [9] | ||
Albendazole monooxygenase (CYP3A4) | Clinical trial Target | Target Info | [4] | ||
Matrix metalloproteinase-13 (MMP-13) | Clinical trial Target | Target Info | [10] | ||
TGF-beta receptor type I (TGFBR1) | Clinical trial Target | Target Info | [11] | ||
Wee1-like protein kinase (WEE1) | Clinical trial Target | Target Info | [12] | ||
Cytochrome P450 1B1 (CYP1B1) | Clinical trial Target | Target Info | [13] | ||
Frizzled-7 receptor (FZD7) | Clinical trial Target | Target Info | [14] | ||
Notch-1 receptor (NOTCH1) | Clinical trial Target | Target Info | [15] | ||
Vascular endothelial growth factor C (VEGFC) | Clinical trial Target | Target Info | [16] | ||
Thrombospondin-1 (THBS1) | Clinical trial Target | Target Info | [17] | ||
Osteoblast cadherin (CDH11) | Clinical trial Target | Target Info | [18] | ||
Suppressor of tumorigenicity 14 protein (ST14) | Patented-recorded Target | Target Info | [19] | ||
Polo-like kinase 2 (PLK2) | Patented-recorded Target | Target Info | [20] | ||
Cyclin A2 (CCNA2) | Literature-reported Target | Target Info | [21] | ||
Cyclic AMP-responsive element-binding protein (CREB1) | Literature-reported Target | Target Info | [22] | ||
Forkhead box protein O1A (FOXO1) | Literature-reported Target | Target Info | [23] | ||
Liver receptor homolog-1 (NR5A2) | Literature-reported Target | Target Info | [24] | ||
Fractalkine (CX3CL1) | Literature-reported Target | Target Info | [25] | ||
Prohibitin (PHB) | Literature-reported Target | Target Info | [26] | ||
Vascular endothelial cadherin (CDH5) | Literature-reported Target | Target Info | [27] | ||
Protein(s) Regulated by This miRNA | #VALUE! | Regulated Protein | [28] | ||
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Regulated Protein | [29] | |||
Calcium-binding protein 39-like | Regulated Protein | [29] | |||
Calponin-3 | Regulated Protein | [29] | |||
COUP transcription factor 2 | Regulated Protein | [30] | |||
Cyclin-G1 | Regulated Protein | [31] | |||
Cyclin-T1 | Regulated Protein | [32] | |||
Cyclin-Y-like protein 1 | Regulated Protein | [29] | |||
Cysteine-rich secretory protein 2 | Regulated Protein | [29] | |||
E3 ubiquitin-protein transferase RMND5A | Regulated Protein | [29] | |||
Eyes absent homolog 4 | Regulated Protein | [7] | |||
Far upstream element-binding protein 2 | Regulated Protein | [34] | |||
Forkhead box protein J3 | Regulated Protein | [35] | |||
High mobility group protein B3 | Regulated Protein | [36] | |||
Huntingtin-interacting protein 1-related protein | Regulated Protein | [37] | |||
Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Regulated Protein | [38] | |||
Mitochondrial fission factor | Regulated Protein | [39] | |||
Mothers against decapentaplegic homolog 2 | Regulated Protein | [11] | |||
Oxysterol-binding protein-related protein 6 | Regulated Protein | [41] | |||
Paired box protein Pax-3 | Regulated Protein | [42] | |||
Paired box protein Pax-7 | Regulated Protein | [42] | |||
Phosphatidate phosphatase LPIN1 | Regulated Protein | [29] | |||
Poly(U)-specific endoribonuclease | Regulated Protein | [29] | |||
Prosaposin | Regulated Protein | [43] | |||
Runt-related transcription factor 1 | Regulated Protein | [44] | |||
Semaphorin-6A | Regulated Protein | [45] | |||
Serine/threonine-protein kinase PINK1, mitochondrial | Regulated Protein | [46] | |||
Serine/threonine-protein kinase WNK1 | Regulated Protein | [29] | |||
Serine/threonine-protein phosphatase CPPED1 | Regulated Protein | [29] | |||
SHC-transforming protein 1 | Regulated Protein | [17] | |||
Thrombospondin-2 | Regulated Protein | [17] | |||
Trafficking protein particle complex subunit 2B | Regulated Protein | [48] | |||
References | |||||
REF 1 | Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer. Int J Oncol. 2015 Feb;46(2):487-96. | ||||
REF 2 | Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. Leukemia. 2013 Mar;27(3):595-603. | ||||
REF 3 | microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem Biophys Res Commun. 2009 Dec 11;390(2):247-51. | ||||
REF 4 | MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos. 2009 Oct;37(10):2112-7. | ||||
REF 5 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis. 2014 May;234(1):54-64. | ||||
REF 6 | Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA. J Biol Chem. 2010 Jun 11;285(24):18184-90. | ||||
REF 7 | A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol. 2011 Jan;131(1):20-9. | ||||
REF 8 | Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013 Jan 17;152(1-2):82-96. | ||||
REF 9 | microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Mol Cancer Ther. 2014 Mar;13(3):742-51. | ||||
REF 10 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82. | ||||
REF 11 | miR-27b inhibits fibroblast activation via targeting TGF signaling pathway. BMC Cell Biol. 2017 Jan 17;18(1):9. | ||||
REF 12 | Prediction of Associations between microRNAs and Gene Expression in Glioma Biology. PLoS One. 2011 Feb 16;6(2):e14681. | ||||
REF 13 | MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 2006 Sep 15;66(18):9090-8. | ||||
REF 14 | MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7. Oncol Rep. 2016 Apr;35(4):2441-50. | ||||
REF 15 | Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf). 2005;(49):341-2. | ||||
REF 16 | MicroRNA-27b, microRNA-101 and microRNA-128 inhibit angiogenesis by down-regulating vascular endothelial growth factor C expression in gastric cancers. Oncotarget. 2015 Nov 10;6(35):37458-70. | ||||
REF 17 | MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):99-109. | ||||
REF 18 | miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition. Oncol Rep. 2016 Mar;35(3):1645-51. | ||||
REF 19 | ST14 (suppression of tumorigenicity 14) gene is a target for miR-27b, and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation. J Biol Chem. 2009 Aug 21;284(34):23094-106. | ||||
REF 20 | MicroRNA-27b up-regulated by human papillomavirus 16 E7 promotes proliferation and suppresses apoptosis by targeting polo-like kinase2 in cervical cancer. Oncotarget. 2016 Apr 12;7(15):19666-79. | ||||
REF 21 | Ionizing radiation-inducible miR-27b suppresses leukemia proliferation via targeting cyclin A2. Int J Radiat Oncol Biol Phys. 2014 Sep 1;90(1):53-62. | ||||
REF 22 | High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer. Oncotarget. 2015 Apr 30;6(12):10646-57. | ||||
REF 23 | miR-27b overexpression improves mitochondrial function in a Sirt1-dependent manner. J Physiol Biochem. 2015 Dec;71(4):753-62. | ||||
REF 24 | Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression. Cell Death Dis. 2016 Nov 3;7(11):e2454. | ||||
REF 25 | Upregulation of KSRP by miR-27b provides IFN--induced post-transcriptional regulation of CX3CL1 in liver epithelial cells. Sci Rep. 2015 Dec 3;5:17590. | ||||
REF 26 | MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells. J Biol Chem. 2013 Nov 29;288(48):34394-402. | ||||
REF 27 | MicroRNA-27b functions as a new inhibitor of ovarian cancer-mediated vasculogenic mimicry through suppression of VE-cadherin expression. RNA. 2017 Jul;23(7):1019-1027. | ||||
REF 28 | Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b.Med Sci Monit. 2016 Oct 1;22:3506-3513. | ||||
REF 29 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 30 | miR-27b inhibits gastric cancer metastasis by targeting NR2F2.Protein Cell. 2017 Feb;8(2):114-122. | ||||
REF 31 | The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer.Oncotarget. 2016 Jan 5;7(1):538-49. | ||||
REF 32 | Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.J Virol. 2012 Mar;86(6):3244-52. | ||||
REF 33 | A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol. 2011 Jan;131(1):20-9. | ||||
REF 34 | miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection.PLoS Pathog. 2012;8(5):e1002702. | ||||
REF 35 | MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes.PLoS One. 2016 Feb 5;11(2):e0148532. | ||||
REF 36 | MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3.Biochem Biophys Res Commun. 2016 Sep 2;477(4):768-773. | ||||
REF 37 | The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related.Oncogene. 2016 Sep 8;35(36):4752-61. | ||||
REF 38 | miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer.J Exp Clin Cancer Res. 2015 Nov 14;34:139. | ||||
REF 39 | miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor.Exp Mol Med. 2014 Nov 28;46:e123. | ||||
REF 40 | miR-27b inhibits fibroblast activation via targeting TGF signaling pathway. BMC Cell Biol. 2017 Jan 17;18(1):9. | ||||
REF 41 | miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.Arterioscler Thromb Vasc Biol. 2016 May;36(5):942-951. | ||||
REF 42 | Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression.Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13383-7. | ||||
REF 43 | The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.J Biol Chem. 2014 Aug 8;289(32):21888-95. | ||||
REF 44 | miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1).PeerJ. 2016 Feb 4;4:e1635. | ||||
REF 45 | MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.Blood. 2012 Feb 9;119(6):1607-16. | ||||
REF 46 | miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).Mol Neurodegener. 2016 Jul 26;11(1):55. | ||||
REF 47 | MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):99-109. | ||||
REF 48 | MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.Gastroenterology. 2008 Nov;135(5):1624-1635.e24. |
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