Drug Information

Drug General Information
Drug ID
D0GD8S
Former ID
DNC004446
Drug Name
GF-109203
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534788]
Structure
Download
2D MOL

3D MOL
Formula
C25H24N4O2
Canonical SMILES
CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=C<br />C=C54
InChI
1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChIKey
QMGUOJYZJKLOLH-UHFFFAOYSA-N
PubChem Compound ID
2396
Target and Pathway
Target(s) Mitogen-activated protein kinase 8 Target Info Inhibitor [525872]
Cell division control protein 2 homolog Target Info Inhibitor [534788]
Protein kinase C gamma type Target Info Inhibitor [529049]
Glycogen synthase kinase-3 beta Target Info Inhibitor [525872]
Mitogen-activated protein kinase 14 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 11 Target Info Inhibitor [525872]
Lck tyrosine kinase Target Info Inhibitor [525872]
RAC serine/threonine-protein kinase Target Info Inhibitor [525872]
G2/mitotic-specific cyclin B1 Target Info Inhibitor [534788]
Mitogen-activated protein kinase 1 Target Info Inhibitor [525872]
Serine/threonine-protein kinase Sgk1 Target Info Inhibitor [525872]
mRNA of PKC-epsilon Target Info Inhibitor [529049]
MAP kinase p38 Target Info Inhibitor [525872]
mRNA of PKC-delta Target Info Inhibitor [529049]
Lethal factor Target Info Inhibitor [528823]
Rho-associated protein kinase 1 Target Info Inhibitor [525872]
Serine/threonine-protein kinase Chk1 Target Info Inhibitor [525872]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04110:Cell cycle
Oocyte meiosis
p53 signaling pathway
Gap junction
Viral carcinogenesishsa04010:MAPK signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Tight junction
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
T cell receptor signaling pathway
B cell receptor signaling pathway
Alzheimer's disease
Measles
Endometrial cancer
Prostate cancer
Basal cell carcinomahsa04010:MAPK signaling pathway
Adrenergic signaling in cardiomyocytes
Platelet activation
Amyotrophic lateral sclerosis (ALS)
Leishmaniasis
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
Primary immunodeficiencyhsa04010:MAPK signaling pathway
cGMP-PKG signaling pathway
AMPK signaling pathway
Apoptosis
Jak-STAT signaling pathway
Estrogen signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Carbohydrate digestion and absorption
Renal cell carcinoma
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04068:FoxO signaling pathway
Progesterone-mediated oocyte maturationhsa04010:MAPK signaling pathway
Dorso-ventral axis formation
TGF-beta signaling pathway
Adherens junction
Regulation of actin cytoskeleton
Prion diseases
Alcoholism
Viral carcinogenesis
Thyroid cancer
Bladder cancer
Aldosterone-regulated sodium reabsorptionhsa04022:cGMP-PKG signaling pathway
MicroRNAs in cancerhsa04010:MAPK signaling pathway
Proteoglycans in cancerhsa04062:Chemokine signaling pathway
Type II diabetes mellitushsa04022:cGMP-PKG signaling pathway
Pathogenic Escherichia coli infection
MicroRNAs in cancerhsa04110:Cell cycle
NetPath Pathway IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_21:RANKL Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
B cell activation
FAS signaling pathway
Integrin signalling pathway
Interferon-gamma signaling pathway
Oxidative stress response
PDGF signaling pathway
Parkinson disease
TGF-beta signaling pathway
T cell activation
Toll receptor signaling pathway
Ras Pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PI3 kinase pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
p53 pathway feedback loops 2
p38 MAPK pathway
p38 MAPK pathwayP00049:Parkinson disease
T cell activationP00005:Angiogenesis
Huntington disease
Hypoxia response via HIF activation
Inflammation mediated by chemokine and cytokine signaling pathway
p53 pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00059:p53 pathwayP00003:Alzheimer disease-amyloid secretase pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Thyrotropin-releasing hormone receptor signaling pathway
p38 MAPK pathwayP00002:Alpha adrenergic receptor signaling pathway
CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
CCKR signaling map ST
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
Noncanonical Wnt signaling pathway
CD40/CD40L signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
IL1-mediated signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
FoxO family signaling
Ceramide signaling pathway
Regulation of Androgen receptor activity
p75(NTR)-mediated signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
JNK signaling in the CD4+ TCR pathway
Nephrin/Neph1 signaling in the kidney podocyte
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Retinoic acid receptors-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
p53 pathway
N-cadherin signaling events
S1P2 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4p73pathway:p73 transcription factor network
E2F transcription factor network
PLK1 signaling events
AP-1 transcription factor network
FOXM1 transcription factor network
Retinoic acid receptors-mediated signalingendothelinpathway:Endothelins
Thromboxane A2 receptor signaling
IL8- and CXCR2-mediated signaling events
PAR1-mediated thrombin signaling events
IL8- and CXCR1-mediated signaling eventslysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
LKB1 signaling events
Canonical Wnt signaling pathway
C-MYC pathway
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by PI3K and PLC-gammaendothelinpathway:Endothelins
p73 transcription factor network
p38 MAPK signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
Plasma membrane estrogen receptor signaling
Regulation of retinoblastoma proteinnfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
TCR signaling in na&#xef
SHP2 signaling
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
IL2 signaling events mediated by STAT5
Alpha-synuclein signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
LPA receptor mediated events
Insulin Pathway
S1P3 pathway
Coregulation of Androgen receptor activity
Regulation of Telomerase
FOXA2 and FOXA3 transcription factor networks
mTOR signaling pathway
IGF1 pathway
E-cadherin signaling in the nascent adherens junction
Integrins in angiogenesis
IFN-gamma pathway
E-cadherin signaling in keratinocytes
Signaling events mediated by the Hedgehog family
Nongenotropic Androgen signaling
Caspase Cascade in Apoptosis
VEGFR1 specific signals
a6b1 and a6b4 Integrin signaling
IL8- and CXCR1-mediated signaling events
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwayp73pathway:p73 transcription factor network
Validated targets of C-MYC transcriptional activation
Direct p53 effectors
C-MYB transcription factor networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
GMCSF-mediated signaling events
EPHB forward signaling
S1P4 pathway
S1P1 pathway
Netrin-mediated signaling events
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
Ras signaling in the CD4+ TCR pathway
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinaseinsulin_pathway:Insulin Pathway
Class I PI3K signaling eventsendothelinpathway:Endothelins
LPA4-mediated signaling events
Regulation of Ras family activation
RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltaendothelinpathway:Endothelins
Syndecan-4-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
Alpha-synuclein signalinganthraxpathway:Cellular roles of Anthrax toxinprlsignalingeventspathway:Signaling events mediated by PRL
PAR4-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling eventsfanconi_pathway:Fanconi anemia pathway
ATR signaling pathway
Circadian rhythm pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-110056:MAPK3 (ERK1) activation
E2F mediated regulation of DNA replication
G0 and Early G1
Cyclin B2 mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signalingR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-156711:Polo-like kinase mediated events
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Regulation of actin dynamics for phagocytic cup formation
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-2672351:Stimuli-sensing channelsR-HSA-114508:Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-168638:NOD1/2 Signaling Pathway
VEGFA-VEGFR2 PathwayR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-5210891:Uptake and function of anthrax toxinsR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKsR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
ErbB Signaling Pathway
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Transcriptional activation by NRF2
NLR Proteins
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
JAK/STAT
PDGF Pathway
Nanoparticle triggered regulated necrosis
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Signalling by NGF
IL-1 signaling pathway
Intrinsic Pathway for Apoptosis
DSCAM interactions
Apoptosis Modulation and Signaling
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP707:DNA Damage Response
G1 to S cell cycle control
PPAR Alpha Pathway
MAP kinase activation in TLR cascade
RAF/MAP kinase cascade
Mitotic Prophase
Mitotic Prometaphase
BMI1
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Regulation of Microtubule Cytoskeleton
Integrated Cancer pathway
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
DAG and IP3 signaling
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+WP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
IL-6 signaling pathway
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
Semaphorin interactions
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
Interferon type I signaling pathways
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
IL-4 Signaling Pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Parkinsons Disease Pathway
FSH signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
Myogenesis
Angiogenesis
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP61:Notch Signaling Pathway
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
EPO Receptor Signaling
Endochondral Ossification
Extracellular vesicle-mediated signaling in recipient cells
Apoptosis-related network due to altered Notch3 in ovarian cancer
Translocation of GLUT4 to the Plasma Membrane
Signal Transduction of S1P Receptor
Primary Focal Segmental Glomerulosclerosis FSGS
Apoptosis
Interleukin-11 Signaling Pathway
TSH signaling pathway
Integrated Breast Cancer Pathway
SREBP signalling
Metabolism of nitric oxide
Integrin-mediated Cell Adhesion
TFs Regulate miRNAs related to cardiac hypertrophy
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP707:DNA Damage Response
miRNA Regulation of DNA Damage Response
AMPK SignalingWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Vitamin A and Carotenoid Metabolism
Hypothetical Network for Drug Addiction
Regulation of Actin Cytoskeleton
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Bladder Cancer
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
Aryl Hydrocarbon Receptor
IL-9 Signaling Pathway
Endothelin Pathways
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Osteopontin Signaling
IL-5 Signaling PathwayWP481:Insulin Signaling
Iron uptake and transport
FSH signaling pathwayWP666:Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
GPCR downstream signaling
Effects of PIP2 hydrolysis
Physiological and Pathological Hypertrophy of the HeartWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
Apoptotic execution phase
Type II diabetes mellitusWP524:G13 Signaling Pathway
Pathogenic Escherichia coli infection
Androgen receptor signaling pathwayWP707:DNA Damage Response
References
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 528823Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. Epub 2007 May 7.Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
Ref 529049J Biol Chem. 2007 Nov 9;282(45):33052-63. Epub 2007 Sep 17.Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.

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