Target General Infomation
Target ID
T98459
Former ID
TTDR00152
Target Name
G2/mitotic-specific cyclin B1
Gene Name
CCNB1
Synonyms
Cyclin B1; CCNB1
Target Type
Research
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Target Validation
T98459
UniProt ID
Sequence
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
ALVQDLAKAVAKV
Inhibitor 3,4-bis(indol-3-yl)maleimide derivative Drug Info [534788]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Drug Info [528032]
3,4-diphenyl-1H-pyrrole-2,5-dione Drug Info [528032]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione Drug Info [528032]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione Drug Info [528032]
4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine Drug Info [530491]
4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine Drug Info [530491]
AZAKENPAULLONE Drug Info [526916]
GF-109203 Drug Info [534788]
KENPAULLONE Drug Info [531040]
RO-316233 Drug Info [534788]
Thieno analogue of kenpaullone Drug Info [526916]
Pathways
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
Progesterone-mediated oocyte maturation
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Validated targets of C-MYC transcriptional activation
PLK1 signaling events
FoxO family signaling
Direct p53 effectors
FOXM1 transcription factor network
C-MYB transcription factor network
Reactome Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Cyclin A/B1 associated events during G2/M transition
G2/M DNA replication checkpoint
Cdk1 complex
WikiPathways DNA Damage Response
G1 to S cell cycle control
Mitotic Prophase
Mitotic Prometaphase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
AMPK Signaling
References
Ref 526916Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Ref 528032J Med Chem. 2006 Feb 23;49(4):1271-81.Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
Ref 530491Eur J Med Chem. 2010 Jan;45(1):379-86. Epub 2009 Oct 13.Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.
Ref 531040Eur J Med Chem. 2010 Sep;45(9):4316-30. Epub 2010 Jun 30.Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.

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