Target General Infomation |
Target ID |
T40097
|
Former ID |
TTDC00102
|
Target Name |
Mitogen-activated protein kinase 8
|
Gene Name |
MAPK8
|
Synonyms |
C-Jun N-terminal kinase 1; JNK-46; JNK1; Stress-activated protein kinase JNK1; MAPK8
|
Target Type |
Clinical Trial
|
Function |
Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of ap-1 such as c-jun and atf2 and thus regulates ap-1 transcriptional activity.
|
BioChemical Class |
Kinase
|
Target Validation |
T40097
|
UniProt ID |
|
EC Number |
EC 2.7.11.24
|
Sequence |
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA GPLGCCR
|
Drugs and Mode of Action |
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) |
Pathways |
References |
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