Target Information
Target General Infomation | |||||
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Target ID |
T64682
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Former ID |
TTDR01250
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Target Name |
Serine/threonine-protein kinase Sgk1
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Gene Name |
SGK1
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Synonyms |
Serum/glucocorticoid-regulated kinase 1; SGK1
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Target Type |
Clinical Trial
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Disease | Prostate cancer [ICD9: 185; ICD10: C61] | ||||
BioChemical Class |
Kinase
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Target Validation |
T64682
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UniProt ID | |||||
EC Number |
EC 2.7.11.1
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Sequence |
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG FSYAPPTDSFL |
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Structure |
2R5T; 3HDM; 3HDN
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Drugs and Mode of Action | |||||
Pathways | |||||
KEGG Pathway | FoxO signaling pathway | ||||
PI3K-Akt signaling pathway | |||||
Aldosterone-regulated sodium reabsorption | |||||
NetPath Pathway | IL5 Signaling Pathway | ||||
FSH Signaling Pathway | |||||
IL2 Signaling Pathway | |||||
Pathway Interaction Database | Insulin Pathway | ||||
Glucocorticoid receptor regulatory network | |||||
mTOR signaling pathway | |||||
FoxO family signaling | |||||
Class I PI3K signaling events | |||||
Reactome | Stimuli-sensing channels | ||||
WikiPathways | Insulin Signaling | ||||
Iron uptake and transport | |||||
FSH signaling pathway | |||||
References | |||||
Ref 525872 | Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. | ||||
Ref 527308 | J Med Chem. 2004 Dec 2;47(25):6239-47.Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. |
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