Target Information
Target General Infomation | |||||
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Target ID |
T75440
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Former ID |
TTDS00454
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Target Name |
Peripheral-type benzodiazepine receptor
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Gene Name |
TSPO
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Synonyms |
Mitochondrial benzodiazepine receptor; PBR; PKBS; Peripheral benzodiazepine receptor; Translocator protein; TSPO
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Target Type |
Successful
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Disease | Anxiety disorder; Insomnia [ICD9: 300, 307.4, 327.0; ICD10: F40-F42, F51.0, G47.0] | ||||
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | |||||
Alzheimer disease [ICD9: 331; ICD10: G30] | |||||
Anxiety disorder; Status epilepticus [ICD9: 300, 345.3; ICD10: F40-F42, G40] | |||||
Brain diseases [ICD10: G00-G99] | |||||
Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
Convulsions [ICD9: 780.3; ICD10: R56.0] | |||||
Epilepsy [ICD10: G40] | |||||
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0] | |||||
Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10: A09, K58, K59.1] | |||||
Lateral sclerosis [ICD10: G12.2] | |||||
Muscle relaxant [ICD10: N39.3, N39.4, R32] | |||||
Nootropic [ICD10: F00-F99] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | |||||
Sedation [ICD9: 338; ICD10: R52, G89] | |||||
Spasms; Pain; Anxiety disorder [ICD9:338, 780, 300, 311; ICD10: R52, G89, F32, F40-F42] | |||||
Function |
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides(PubMed:1847678).
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BioChemical Class |
Cholesterol porphyrin uptake translocator
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Target Validation |
T75440
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UniProt ID | |||||
Sequence |
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE |
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Drugs and Mode of Action | |||||
Drug(s) | Adinazolam | Drug Info | Approved | Anxiety disorder; Status epilepticus | [550684] |
ALPIDEM | Drug Info | Approved | Anxiety disorder | [551871] | |
Alprazolam | Drug Info | Approved | Anxiety disorder | [538259], [542118] | |
Chlordiazepoxide | Drug Info | Approved | Anxiety disorder | [535828], [540324] | |
Chlormezanone | Drug Info | Approved | Spasms; Pain; Anxiety disorder | [538447], [542346], [551871] | |
Cinolazepam | Drug Info | Approved | Muscle relaxant | [550708] | |
Clorazepate | Drug Info | Approved | Anxiety disorder; Insomnia | [538240], [542549] | |
Clotiazepam | Drug Info | Approved | Anxiety disorder | [550777] | |
Diazepam | Drug Info | Approved | Epilepsy | [524426], [540319] | |
Estazolam | Drug Info | Approved | Insomnia | [538287], [542551] | |
Eszopiclone | Drug Info | Approved | Insomnia | [536647], [542452] | |
Fludiazepam | Drug Info | Approved | Anxiety disorder | [550695] | |
Flumazenil | Drug Info | Approved | Benzodiazepine overdoses | [467528], [522823] | |
Flunitrazepam | Drug Info | Approved | Insomnia | [467696], [550754] | |
Flurazepam | Drug Info | Approved | Insomnia | [538223], [542199] | |
Halazepam | Drug Info | Approved | Anxiety disorder | [538493], [542207] | |
Lorazepam | Drug Info | Approved | Anxiety disorder | [538231], [541183] | |
Midazolam | Drug Info | Approved | Sedation | [538292], [540301] | |
Oxazepam | Drug Info | Approved | Anxiety disorder | [536565], [542271] | |
Prazepam | Drug Info | Approved | Anxiety disorder | [542295], [550778] | |
Quazepam | Drug Info | Approved | Insomnia | [538513], [542308] | |
Temazepam | Drug Info | Approved | Insomnia | [538229], [542322] | |
Triazolam | Drug Info | Approved | Insomnia | [536565], [542336] | |
11C-PBR-28 | Drug Info | Phase 2 | Brain diseases | [525281] | |
Dextofisopam | Drug Info | Phase 2 | Irritable bowel syndrome | [536224] | |
ONO-2952 | Drug Info | Phase 2 | Irritable bowel syndrome | [524339] | |
SSR-180575 | Drug Info | Phase 2 | Rheumatoid arthritis | [522067] | |
TLN-4601 | Drug Info | Phase 2 | Cancer | [522396] | |
18F-FEDAA-1106 | Drug Info | Phase 1 | Alzheimer disease | [549054] | |
BAY-85-8102 | Drug Info | Phase 1 | Brain diseases | [522842] | |
Ro-16-6028 | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [467491], [544696] | |
Emapunil | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [543259], [547175] | |
Lirequinil | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [545048] | |
S-8510 | Drug Info | Discontinued in Phase 2 | Nootropic | [545890] | |
TRO-40303 | Drug Info | Discontinued in Phase 2 | Lateral sclerosis | [549216] | |
Imepitoin | Drug Info | Discontinued in Phase 1 | Convulsions | [546470] | |
DAA-1097 | Drug Info | Terminated | Anxiety disorder | [547051] | |
Ginkgolide B (GKB) | Drug Info | Terminated | Discovery agent | [544554] | |
Miltirone | Drug Info | Terminated | Anxiety disorder | [545493] | |
NNC-13-8119 | Drug Info | Terminated | Anxiety disorder | [545660] | |
NS-2979 | Drug Info | Terminated | Pain | [547155] | |
PK 11195 | Drug Info | Terminated | Discovery agent | [543258], [544695] | |
Ro 5-4864 | Drug Info | Terminated | Discovery agent | [545047] | |
Inhibitor | (R)PK-11195 | Drug Info | [526488] | ||
2-(2-Phenyl-1H-indol-3-yl)-N,N-dipropyl-acetamide | Drug Info | [534032] | |||
4-Methoxy-5-phenyl-6-thia-10b-aza-benzo[e]azulene | Drug Info | [533589] | |||
5-Phenyl-6-thia-10b-aza-benzo[e]azulen-4-one | Drug Info | [533922] | |||
5-Phenyl-6-thia-10b-aza-benzo[e]azulene | Drug Info | [533589] | |||
6-Thia-10b-aza-benzo[e]azulen-4-one | Drug Info | [533922] | |||
ALPIDEM | Drug Info | [529656] | |||
N,N-Diethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [534032] | |||
N,N-Dihexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [534032] | |||
N,N-Dimethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [534032] | |||
N-Hexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [534032] | |||
SSR-180575 | Drug Info | [526341], [551871] | |||
Binder | 11C-PBR-170 | Drug Info | [543743] | ||
11C-PBR-28 | Drug Info | [528547] | |||
Cinolazepam | Drug Info | [537708] | |||
FGIN-1-27 | Drug Info | [535317] | |||
PK 11195 | Drug Info | [535317] | |||
Ro 5-4864 | Drug Info | [535317], [538133] | |||
TGSC01AA(4) | Drug Info | [543743] | |||
Modulator | 18F-FEDAA-1106 | Drug Info | [526694] | ||
Chlordiazepoxide | Drug Info | [556264] | |||
Clorazepate | Drug Info | [556264] | |||
Flurazepam | Drug Info | [556264] | |||
Halazepam | Drug Info | [556264] | |||
Lorazepam | Drug Info | [556264] | |||
Midazolam | Drug Info | [556264] | |||
Miltirone | Drug Info | [528077] | |||
NNC-13-8119 | Drug Info | [545661] | |||
NS-2979 | Drug Info | [547156] | |||
Prazepam | Drug Info | [556264] | |||
Quazepam | Drug Info | [556264] | |||
Ro-16-6028 | Drug Info | ||||
Temazepam | Drug Info | [556264] | |||
TLN-4601 | Drug Info | ||||
Triazolam | Drug Info | [556264] | |||
TRO-40303 | Drug Info | [544374] | |||
U-89854 | Drug Info | [543743] | |||
Agonist | Adinazolam | Drug Info | [534872] | ||
Alprazolam | Drug Info | [536166], [537330] | |||
BAY-85-8102 | Drug Info | [543743] | |||
Benzodiazepine | Drug Info | [543743] | |||
Chlormezanone | Drug Info | [537816] | |||
Clotiazepam | Drug Info | [537693] | |||
DAA-1097 | Drug Info | [525488] | |||
Dextofisopam | Drug Info | [536224] | |||
Diazemuls | Drug Info | [537354] | |||
Diazepam | Drug Info | [530408] | |||
Emapunil | Drug Info | [536580] | |||
Estazolam | Drug Info | [535677], [536079] | |||
Eszopiclone | Drug Info | [536166], [536625] | |||
Fludiazepam | Drug Info | [537701] | |||
Flunitrazepam | Drug Info | [537330] | |||
Imepitoin | Drug Info | [532596] | |||
Lirequinil | Drug Info | [534064] | |||
Oxazepam | Drug Info | [536807] | |||
S-8510 | Drug Info | [551871] | |||
Antagonist | Flumazenil | Drug Info | [543743] | ||
ONO-2952 | Drug Info | [533291] | |||
Suppressor | Ginkgolide B (GKB) | Drug Info | [535072] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
HTLV-I infection | |||||
References | |||||
Ref 467491 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4146). | ||||
Ref 467528 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4192). | ||||
Ref 467696 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4360). | ||||
Ref 522067 | ClinicalTrials.gov (NCT00502515) Dose-effect of SSR180575 in Diabetic Neuropathy. U.S. National Institutes of Health. | ||||
Ref 522396 | ClinicalTrials.gov (NCT00730262) Efficacy Study of TLN-4601 in Patients With Recurring Glioblastoma Multiforme. U.S. National Institutes of Health. | ||||
Ref 522823 | ClinicalTrials.gov (NCT00997087) A Randomized, Double-Blind, Placebo-Controlled Trial of Flumazenil for the Treatment of Obsessive Compulsive Disorder. U.S. National Institutes of Health. | ||||
Ref 522842 | ClinicalTrials.gov (NCT01009359) Evaluation of the Neuroinflammation Pattern of BAY85-8102 F-18, DPA-714 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of F18, DPA-714 in Healthy Volunteers. U.S. National Institutes of Health. | ||||
Ref 524339 | ClinicalTrials.gov (NCT01887002) Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D). U.S. National Institutes of Health. | ||||
Ref 524426 | ClinicalTrials.gov (NCT01939093) Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis. U.S. National Institutes of Health. | ||||
Ref 525281 | ClinicalTrials.gov (NCT02513589) Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke. | ||||
Ref 535828 | Use of the accelerating rotarod for assessment of motor performance decrement induced by potential anticonvulsant compounds in nerve agent poisoning. Drug Chem Toxicol. 1992;15(3):177-201. | ||||
Ref 536224 | Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. | ||||
Ref 536565 | What every dentist should know about the "z-sedatives". J Mass Dent Soc. 2007 Fall;56(3):44-5. | ||||
Ref 538223 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070344. | ||||
Ref 538229 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070919. | ||||
Ref 538231 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071117. | ||||
Ref 538240 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071852. | ||||
Ref 538259 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074046. | ||||
Ref 538287 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074818. | ||||
Ref 538292 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075154. | ||||
Ref 538447 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011467. | ||||
Ref 538493 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017736. | ||||
Ref 538513 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018708. | ||||
Ref 540301 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3342). | ||||
Ref 540319 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3364). | ||||
Ref 540324 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3370). | ||||
Ref 541183 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5884). | ||||
Ref 542118 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7111). | ||||
Ref 542199 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7188). | ||||
Ref 542207 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7195). | ||||
Ref 542271 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7253). | ||||
Ref 542295 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7275). | ||||
Ref 542308 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7288). | ||||
Ref 542322 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7300). | ||||
Ref 542336 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7313). | ||||
Ref 542346 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7323). | ||||
Ref 542452 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7429). | ||||
Ref 542549 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7548). | ||||
Ref 542551 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7550). | ||||
Ref 543258 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8703). | ||||
Ref 543259 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8704). | ||||
Ref 544554 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000117) | ||||
Ref 544695 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000635) | ||||
Ref 544696 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000640) | ||||
Ref 545047 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001966) | ||||
Ref 545048 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001968) | ||||
Ref 545493 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003466) | ||||
Ref 545660 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004060) | ||||
Ref 545890 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005238) | ||||
Ref 546470 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008368) | ||||
Ref 547051 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012540) | ||||
Ref 547155 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013494) | ||||
Ref 547175 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013611) | ||||
Ref 549054 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031827) | ||||
Ref 525488 | Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. Life Sci. 1999;64(16):1455-64. | ||||
Ref 526341 | SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J PharmacolExp Ther. 2002 Jun;301(3):1067-78. | ||||
Ref 526488 | Bioorg Med Chem Lett. 2003 Jan 20;13(2):201-4.[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). | ||||
Ref 526694 | Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion. J Pharmacol Exp Ther. 2003 Sep;306(3):828-37. | ||||
Ref 528077 | Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991 Jun 24;127(2):237-41. | ||||
Ref 528547 | PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci Lett. 2007 Jan 16;411(3):200-5. Epub 2006 Nov28. | ||||
Ref 529656 | J Med Chem. 2008 Sep 25;51(18):5798-806. Epub 2008 Aug 26.Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. | ||||
Ref 530408 | Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8. | ||||
Ref 532596 | The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs. 2014 Jan;28(1):29-43. | ||||
Ref 533291 | Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Jul 17;99:51-66. | ||||
Ref 533589 | J Med Chem. 1995 Nov 10;38(23):4730-8.A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors. | ||||
Ref 533922 | J Med Chem. 1994 May 13;37(10):1427-38.Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies. | ||||
Ref 534032 | J Med Chem. 1993 Oct 1;36(20):2908-20.Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. | ||||
Ref 534064 | Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. | ||||
Ref 534872 | Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22. | ||||
Ref 535072 | Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells. Anticancer Res. 2000 Sep-Oct;20(5A):2835-47. | ||||
Ref 535317 | Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. | ||||
Ref 535677 | Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem. 2003 Mar 6;11(5):769-73. | ||||
Ref 536079 | Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3126-9. | ||||
Ref 536224 | Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. | ||||
Ref 536580 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
Ref 536807 | Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9. Epub 2008 Jul 19. | ||||
Ref 537330 | Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. | ||||
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