Drug Information

Drug General Information
Drug ID
D09OTU
Former ID
DIB012122
Drug Name
SSR-180575
Synonyms
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [522067]
Structure
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2D MOL

3D MOL
Formula
C21H19ClN4O2
Canonical SMILES
CN1C2=C(C=CC(=C2)Cl)C3=C1C(=O)N(N=C3CC(=O)N(C)C)C4=CC=C<br />C=C4
InChI
1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3
InChIKey
HJSQVJOROCIILI-UHFFFAOYSA-N
CAS Number
CAS 220448-02-2
PubChem Compound ID
9930560
PubChem Substance ID
14903304, 24205983, 50030660, 76786153, 103609041, 104107226, 140582900, 160826856, 162223899, 163093025, 163387116, 163841168, 170539558, 172872971, 180388010, 189561549, 203103194, 204419138, 223532856, 226555635, 248905271, 249729393, 252463861
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Inhibitor [526341], [551871]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 522067ClinicalTrials.gov (NCT00502515) Dose-effect of SSR180575 in Diabetic Neuropathy. U.S. National Institutes of Health.
Ref 526341SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J PharmacolExp Ther. 2002 Jun;301(3):1067-78.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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