Drug Information

Drug General Information
Drug ID
D0R4DP
Former ID
DAP000932
Drug Name
Clotiazepam
Synonyms
Clotiazepamum; Clozan; Distensan; Rise; Rize; Rizen; Tienor; Trecalmo; Veratran; Y 6047; Clotiazepam [INN:JAN]; Clotiazepamum [INN-Latin]; Clozan (TN); Distensan (TN); Rize (TN); Rizen (TN); Trecalmo (TN); Veratran (TN); Y-6047; Clotiazepam (JP15/INN); 2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-(8CI); 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one; 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one; 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one; 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Approved [550777]
Therapeutic Class
Hypnotics and Sedatives
Structure
Download
2D MOL

3D MOL
Formula
C16H15ClN2OS
Canonical SMILES
CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C
InChI
1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
InChIKey
CHBRHODLKOZEPZ-UHFFFAOYSA-N
CAS Number
CAS 33671-46-4
PubChem Compound ID
2811
PubChem Substance ID
4821018, 7848391, 8151818, 10519139, 12015458, 15445216, 29221966, 46508776, 48415812, 50053288, 50458572, 57321476, 58106918, 104301682, 109612938, 124973749, 125823447, 126666095, 127624260, 134221992, 134338208, 135000200, 137005586, 160964803, 164838520, 179150338, 198987699, 198993221, 223668114, 224743438, 226428801, 241062689, 250113220, 252399059
SuperDrug ATC ID
N05BA21
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Agonist [537693]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 550777Drug information of Clotiazepam, 2008. eduDrugs.
Ref 537693Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.

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