Drug General Information
Drug ID
D01XOD
Former ID
DNC012025
Drug Name
ALPIDEM
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Approved [551871]
Structure
Download
2D MOL

3D MOL

Formula
C21H23Cl2N3O
Canonical SMILES
CCCN(CCC)C(=O)CC1=C(N=C2N1C=C(C=C2)Cl)C3=CC=C(C=C3)Cl
InChI
1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
InChIKey
JRTIDHTUMYMPRU-UHFFFAOYSA-N
CAS Number
CAS 82626-01-5
PubChem Compound ID
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [534470]
Peripheral-type benzodiazepine receptor Target Info Inhibitor [529656]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 529656J Med Chem. 2008 Sep 25;51(18):5798-806. Epub 2008 Aug 26.Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Ref 534470J Med Chem. 1997 Sep 12;40(19):3109-18.Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.

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