Target Information
Target General Infomation | |||||
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Target ID |
T57392
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Former ID |
TTDS00475
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Target Name |
Cytochrome P450 2D6
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Gene Name |
CYP2D6
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Synonyms |
CYP2DL1; CYPIID6; Debrisoquine 4-hydroxylase; P450-DB1; CYP2D6
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Target Type |
Successful
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Disease | Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0] | ||||
Malaria [ICD10: B54] | |||||
Migraine [ICD9: 346; ICD10: G43] | |||||
Function |
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
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BioChemical Class |
Oxidoreductases acting on paired donors
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Target Validation |
T57392
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UniProt ID | |||||
EC Number |
EC 1.14.14.1
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Sequence |
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR |
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Drugs and Mode of Action | |||||
Inhibitor | (2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine | Drug Info | [527617] | ||
(5-(pyridin-3-yl)furan-2-yl)methanamine | Drug Info | [528540] | |||
(5-phenylfuran-2-yl)methanamine | Drug Info | [528540] | |||
(5-pyridin-3-yl-furan-2-yl)methanethiol | Drug Info | [528540] | |||
1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one | Drug Info | [529286] | |||
1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) | Drug Info | [530957] | |||
1-(4-Butoxy-phenyl)-1H-imidazole | Drug Info | [526913] | |||
1-(METHOXYMETHYL)-6-(NAPHTHALEN-2-YL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) | Drug Info | [530957] | |||
1H-1,2,3-benzotriazol-1-amine | Drug Info | [526196] | |||
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole | Drug Info | [530846] | |||
2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine | Drug Info | [526913] | |||
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol | Drug Info | [530450] | |||
2-Hexyloxy-5-imidazol-1-yl-pyridine | Drug Info | [526913] | |||
2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine | Drug Info | [526913] | |||
3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine | Drug Info | [529624] | |||
3-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine | Drug Info | [526913] | |||
4-(3-Pent-1-ynyl-benzyl)-1H-imidazole | Drug Info | [529437] | |||
4-(3-Phenylethynyl-benzyl)-1H-imidazole | Drug Info | [529437] | |||
4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide | Drug Info | [530324] | |||
4-methylaminomethyl-7-methoxycoumarin | Drug Info | [531159] | |||
4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-morpholine | Drug Info | [526913] | |||
4-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine | Drug Info | [526913] | |||
4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol | Drug Info | [530450] | |||
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol | Drug Info | [530450] | |||
6-(3,4-DICHLOROPHENYL)-1-[1-(METHYLOXY)-3-BUTEN-1-YL]-3-AZABICYCLO[4.1.0]HEPTANE (DIASTEREOMERIC MIX) | Drug Info | [530957] | |||
Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amine | Drug Info | [527367] | |||
BMS-694153 | Drug Info | [529618] | |||
BS 7581 | Drug Info | [528130] | |||
BS 7840 | Drug Info | [528130] | |||
BS 9106 | Drug Info | [528130] | |||
Desethyl isoquine | Drug Info | [529965] | |||
DIHYDROCUBEBIN | Drug Info | [527404] | |||
GB-12819 | Drug Info | [528130] | |||
GBR 12530 | Drug Info | [528130] | |||
GBR-12289 | Drug Info | [528130] | |||
GNF-PF-2094 | Drug Info | [530517] | |||
GNF-PF-4292 | Drug Info | [534050] | |||
GNF-PF-5411 | Drug Info | [534050] | |||
Go-Y022 | Drug Info | [529286] | |||
ICI-199441 | Drug Info | [527541] | |||
ISOQUINE | Drug Info | [529965] | |||
Kaempferol-3-O-methyl ether | Drug Info | [527147] | |||
Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine | Drug Info | [527367] | |||
ML-3163 | Drug Info | [526668] | |||
Prodipine | Drug Info | [534050] | |||
SB-210313 | Drug Info | [534804] | |||
Inducer | Glutethimide | Drug Info | [536862], [537887] | ||
Pathways | |||||
KEGG Pathway | Metabolism of xenobiotics by cytochrome P450 | ||||
Drug metabolism - cytochrome P450 | |||||
Serotonergic synapse | |||||
Reactome | Xenobiotics | ||||
WikiPathways | Metapathway biotransformation | ||||
Tamoxifen metabolism | |||||
Oxidation by Cytochrome P450 | |||||
Vitamin D Receptor Pathway | |||||
Aripiprazole Metabolic Pathway | |||||
Fatty Acid Omega Oxidation | |||||
Codeine and Morphine Metabolism | |||||
References | |||||
Ref 532126 | Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes. J Antimicrob Chemother. 2013 Apr;68(4):786-8. | ||||
Ref 526196 | Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. | ||||
Ref 526668 | J Med Chem. 2003 Jul 17;46(15):3230-44.Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. | ||||
Ref 526913 | Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. | ||||
Ref 527147 | J Nat Prod. 2004 Jul;67(7):1079-83.Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. | ||||
Ref 527367 | J Med Chem. 2005 Jan 13;48(1):224-39.5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. | ||||
Ref 527541 | Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52.Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. | ||||
Ref 527617 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3816-20.A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series. | ||||
Ref 528130 | J Med Chem. 2006 Apr 20;49(8):2417-30.Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. | ||||
Ref 528540 | J Med Chem. 2006 Nov 30;49(24):6987-7001.Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. | ||||
Ref 529286 | Eur J Med Chem. 2008 Aug;43(8):1621-31. Epub 2007 Nov 17.Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. | ||||
Ref 529437 | J Med Chem. 2008 May 22;51(10):2944-53. Epub 2008 Apr 24.4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. | ||||
Ref 529618 | J Med Chem. 2008 Aug 28;51(16):4858-61. Epub 2008 Jul 30.Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. | ||||
Ref 529624 | J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity. | ||||
Ref 529965 | J Med Chem. 2009 Mar 12;52(5):1408-15.Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | ||||
Ref 530324 | J Med Chem. 2009 Sep 24;52(18):5685-702.Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). | ||||
Ref 530450 | J Med Chem. 2009 Nov 12;52(21):6724-43.New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity. | ||||
Ref 530517 | Bioorg Med Chem Lett. 2010 Jan 1;20(1):228-31. Epub 2009 Oct 31.Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. | ||||
Ref 530846 | J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice. | ||||
Ref 530957 | J Med Chem. 2010 Jul 8;53(13):4989-5001.6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. | ||||
Ref 531159 | J Med Chem. 2010 Oct 14;53(19):7129-39.Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. | ||||
Ref 534050 | J Med Chem. 1993 Apr 30;36(9):1136-45.Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. | ||||
Ref 534804 | Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6.Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. |
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