| Drug General Information |
| Drug ID |
D01ARE
|
| Former ID |
DNC004832
|
| Drug Name |
Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H10N2S
|
| Canonical SMILES |
CNC1=CC=C(S1)C2=CN=CC=C2
|
| InChI |
1S/C10H10N2S/c1-11-10-5-4-9(13-10)8-3-2-6-12-7-8/h2-7,11H,1H3
|
| InChIKey |
OUEHWWLIEPNPDR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 2D6 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Metabolism of xenobiotics by cytochrome P450
|
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Drug metabolism - cytochrome P450
|
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Serotonergic synapsehsa00140:Steroid hormone biosynthesis
|
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Linoleic acid metabolism
|
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Retinol metabolism
|
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Drug metabolism - other enzymes
|
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Metabolic pathways
|
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Bile secretion
|
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Chemical carcinogenesis
|
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PathWhiz Pathway
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Caffeine Metabolism
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Retinol Metabolism
|
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Reactome
|
XenobioticsR-HSA-211981:Xenobiotics
|
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Aflatoxin activation and detoxification
|
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WikiPathways
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Metapathway biotransformation
|
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Tamoxifen metabolism
|
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Oxidation by Cytochrome P450
|
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Vitamin D Receptor Pathway
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Aripiprazole Metabolic Pathway
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Fatty Acid Omega Oxidation
|
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Codeine and Morphine MetabolismWP702:Metapathway biotransformation
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Aflatoxin B1 metabolism
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Estrogen metabolism
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Benzo(a)pyrene metabolism
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Tryptophan metabolism
|
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
|
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Codeine and Morphine Metabolism
|
| References |
| REF 1 | J Med Chem. 2005 Jan 13;48(1):224-39.5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. |
|---|
