Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T06273 | ||||
Target Name | Poly [ADP-ribose] polymerase-1 | ||||
Target Type | Successful |
||||
Drug Potency against Target | 3-aminobenzo[c][1,5]naphthyridin-6(5H)-one | Drug Info | IC50 = 180 nM | [529901] | |
(E)-N-(4-Phenylthiazol-2-yl) cinnamamide | Drug Info | IC50 = 224 nM | [529901] | ||
AG-014376 | Drug Info | Ki = 6.4 nM | [527248] | ||
2-Methylquinoline-8-carboxamide | Drug Info | IC50 = 500 nM | [529894] | ||
8-Nitro-6H,11H-indeno[1,2-c]isoquinolin-5-one | Drug Info | IC50 = 500 nM | [527674] | ||
CEP-6800 | Drug Info | IC50 = 18 nM | [528503] | ||
ABT-888 | Drug Info | Ki = 5 nM | [529921] | ||
BSI-201 | Drug Info | EC50 = 1.4 nM | [552548] | ||
3-Morpholin-4-ylmethyl-5H-phenanthridin-6-one | Drug Info | IC50 = 23 nM | [527682] | ||
4-(5-Morpholin-4-yl-pentyl)-2H-phthalazin-1-one | Drug Info | IC50 = 119 nM | [527682] | ||
4-(4-Morpholin-4-yl-butyl)-2H-phthalazin-1-one | Drug Info | IC50 = 950 nM | [527682] | ||
3-Ethenylquinoline-8-carboxamide | Drug Info | IC50 = 5800 nM | [529894] | ||
9-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one | Drug Info | IC50 = 650 nM | [527674] | ||
5-amino-3,4-dihydroisoquinolin-1(2H)-one | Drug Info | IC50 = 410 nM | [530584] | ||
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | Drug Info | IC50 = 10000 nM | [527871] | ||
8-Methoxy-2-methyl-3H-quinazolin-4-one | Drug Info | IC50 = 780 nM | [534774] | ||
KU-0058948 | Drug Info | IC50 = 3.4 nM | [530062] | ||
2-ethylquinoline-8-carboxamide | Drug Info | IC50 = 800 nM | [529894] | ||
3-Hydroxy-benzamide | Drug Info | IC50 = 8000 nM | [534774] | ||
2,3-dihydro-1H-benzo[de]isoquinolin-1-one | Drug Info | IC50 = 540 nM | [530584] | ||
5-Chloro-2-methyl-3H-quinazolin-4-one | Drug Info | IC50 = 1200 nM | [527159] | ||
2-(3-Piperidin-1-yl-propyl)-3H-quinazolin-4-one | Drug Info | IC50 = 1100 nM | [527159] | ||
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione | Drug Info | IC50 = 40 nM | [527871] | ||
5-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | Drug Info | IC50 = 5000 nM | [527871] | ||
2-(4-Chlorophenyl)-2H-indazole-7-carboxamide | Drug Info | IC50 = 24 nM | [530485] | ||
2-Benzyl-2H-indazole-7-carboxamide | Drug Info | IC50 = 130 nM | [530485] | ||
9-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one | Drug Info | IC50 = 98 nM | [527674] | ||
2-(3-Chlorophenyl)-2H-indazole-7-carboxamide | Drug Info | IC50 = 14 nM | [530485] | ||
Nicotinamide | Drug Info | IC50 = 7800000 nM | [553187] | ||
2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-one | Drug Info | IC50 = 520 nM | [534774] | ||
Olaparib | Drug Info | IC50 = 6 nM | [536853] | ||
Rucaparib | Drug Info | Ki < 5 nM | |||
8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | Drug Info | IC50 = 130 nM | [534774] | ||
8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one | Drug Info | IC50 = 850 nM | [534774] | ||
3-Ethynylquinoline-8-carboxamide | Drug Info | IC50 = 2300 nM | [529894] | ||
2-phenylquinoline-8-carboxamide | Drug Info | IC50 = 900 nM | [529894] | ||
Quinoline-8-carboxamide | Drug Info | IC50 = 1900 nM | [529894] | ||
3-Ethylquinoline-8-carboxamide | Drug Info | IC50 = 3700 nM | [529894] | ||
3-Methylquinoline-8-carboxamide | Drug Info | IC50 = 3400 nM | [529894] | ||
3-Prop-1-ynylquinoline-8-carboxamide | Drug Info | IC50 = 2200 nM | [529894] | ||
2-(4-methoxyphenyl)quinoline-8-carboxamide | Drug Info | IC50 = 1100 nM | [529894] | ||
8-Methoxy-2-phenyl-3H-quinazolin-4-one | Drug Info | IC50 = 4200 nM | [534774] | ||
2-phenylpyrazolo-[1,5-a]pyridine-7-carboxamide | Drug Info | IC50 = 55 nM | [530485] | ||
2-(2-Chlorophenyl)-2H-indazole-7-carboxamide | Drug Info | IC50 = 100 nM | [530485] | ||
KU-58684 | Drug Info | IC50 = 5 nM | [529901] | ||
3-Phenylquinoline-8-carboxamide | Drug Info | IC50 = 15000 nM | [529894] | ||
8-Hydroxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one | Drug Info | IC50 = 230 nM | [534774] | ||
2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one | Drug Info | IC50 = 190 nM | [534774] | ||
2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-one | Drug Info | IC50 = 440 nM | [534774] | ||
1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one | Drug Info | IC50 = 7500 nM | [529901] | ||
4-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | Drug Info | IC50 = 2000 nM | [527871] | ||
3-(4-methoxyphenyl)quinoxaline-5-carboxamide | Drug Info | IC50 = 71 nM | [529901] | ||
4-benzylphthalazin-1(2H)-one | Drug Info | IC50 = 770 nM | [529901] | ||
5-aminoisoquinolin-1(2H)-one | Drug Info | IC50 = 1800 nM | [529894] | ||
Benzo[c][1,5]naphthyridin-6(5H)-one | Drug Info | IC50 = 116 nM | [529901] | ||
2-phenyl-2H-indazole-7-carboxamide | Drug Info | IC50 = 24 nM | [530485] | ||
3-(4-aminophenyl)quinoxaline-5-carboxamide | Drug Info | IC50 = 87 nM | [529901] | ||
2-phenyl-2H-benzo[d][1,2,3]triazole-4-carboxamide | Drug Info | IC50 = 71 nM | [530485] | ||
8-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one | Drug Info | IC50 = 300 nM | [527674] | ||
8-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one | Drug Info | IC50 = 500 nM | [527674] | ||
3-Amino-benzamide | Drug Info | IC50 = 19100 nM | [534774] | ||
PD-128763 | Drug Info | IC50 = 440 nM | [534774] | ||
3-(4-cyanophenyl)quinoxaline-5-carboxamide | Drug Info | IC50 = 101 nM | [529901] | ||
Pyrrolo[3,4-e]indole-1,3(2H,6H)-dione | Drug Info | IC50 = 750 nM | [527871] | ||
2-(4-Azido-phenyl)-8-methoxy-3H-quinazolin-4-one | Drug Info | IC50 = 1930 nM | [534774] | ||
2,8-Dimethyl-3H-quinazolin-4-one | Drug Info | IC50 = 390 nM | [534774] | ||
4-amino-1,8-naphthalimide | Drug Info | IC50 = 26 nM | [527871] | ||
2H-Isoquinolin-1-one | Drug Info | IC50 = 15800 nM | [534774] | ||
8-Methyl-2-phenyl-3H-quinazolin-4-one | Drug Info | IC50 = 870 nM | [534774] | ||
8-Hydroxy-2-phenyl-3H-quinazolin-4-one | Drug Info | IC50 = 1060 nM | [534774] | ||
N-(4-Phenylthiazol-2-yl)isonicotinamide | Drug Info | IC50 = 753 nM | [529901] | ||
2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one | Drug Info | IC50 = 220 nM | [534774] | ||
References | |||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 527248 | J Med Chem. 2004 Oct 21;47(22):5467-81.Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 527674 | J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | ||||
Ref 528503 | Bioorg Med Chem Lett. 2007 Jan 15;17(2):542-5. Epub 2006 Oct 10.Novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529921 | J Med Chem. 2009 Jan 22;52(2):514-23.Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. | ||||
Ref 552548 | Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2). Curr Top Med Chem. 2005;5(9):869-84. | ||||
Ref 527682 | Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. | ||||
Ref 527682 | Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. | ||||
Ref 527682 | Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 527674 | J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | ||||
Ref 530584 | Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 530062 | J Med Chem. 2009 May 14;52(9):3108-11.Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 530584 | Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. Epub 2009 Dec 4.Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). | ||||
Ref 527159 | J Med Chem. 2004 Aug 12;47(17):4151-4.Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. | ||||
Ref 527159 | J Med Chem. 2004 Aug 12;47(17):4151-4.Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 527674 | J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 553187 | Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. Inflammation. 1995 Jun;19(3):379-87. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 536853 | 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91. Epub 2008 Sep 19. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 529894 | J Med Chem. 2009 Feb 12;52(3):868-77.Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 530485 | J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | ||||
Ref 527674 | J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | ||||
Ref 527674 | J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 527871 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). | ||||
Ref 529901 | J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. | ||||
Ref 534774 | J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). |
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